Ian Pike

[Ian Pike @ProteomicsIan]

#AAIC2015 Khalid Iqbal proposing N-terminus of tau may be toxic region. Immunotherapy should neutralise this.

[Ian Pike @ProteomicsIan]

#AAIC2015 Day 3 afternoon session on preclinical tau therapeutics is busy!

[Ian Pike @ProteomicsIan]

@sussexblue over a period of time generally. Less obvious contacts at the meeting can lead to most valuable discussions later

[Ian Pike @ProteomicsIan]

#AAIC2015 best session of the day for me was on links between sleep and AS pathologies. Matt Walker excellent on amyloid link to NREM change

[Ian Pike @ProteomicsIan]

Busy day at #AAIC2015 today but where were half the poster presenters? It is becoming a real problem at these big conferences.

[Ian Pike @ProteomicsIan]

#AAIC2015 G Stutzman ryanodine receptor 2 as drug target. Impressive work explaining a benefit of our CK1D inhibitors reducing RyR2 levels

[Ian Pike @ProteomicsIan]

My second talk at #AAIC2015 using different TMT workflows for translational studies on pharmacodynamic biomarkers in AD @ProteomeScience

[Ian Pike @ProteomicsIan]

Imaging shows early astrocytosis in presymptomatic AD. Need to correlate astrocyte proteins in CSF with imaging. #AAIC2015

[Ian Pike @ProteomicsIan]

#AAIC2015 Ballroom B at 2pm. Hunting low abundant microbial biomarkers using TMTcalibrator @ProteomeScience

[Ian Pike @ProteomicsIan]

1 hour to my first talk at #AAIC2015. I will show how new proteoMics method TMTcalibrator identified low abundant microglial proteins in CSF

[Ian Pike @ProteomicsIan]

Trouble with talks at #AAIC2015 is the urge to look for every pathway mentioned in our SysQuant and TMTcalibrator data. Awesome coverage

[Ian Pike @ProteomicsIan]

First day at #AAIC2015 starting with session on innate immunity in AD. Link between NFkB and C3 causing cell death - fits our biomarker data

[Ian Pike @ProteomicsIan]

I am speaking at a Thermo sponsored event at Doubletree hotel Southampton Row, Central London at 2pm today. Lots of space, drop by if u can

[Ian Pike @ProteomicsIan]

So #ADPD2015 is over with great sessions on tau and Microglia to close out a brilliant week. Now to try and make sense of it all a bientot.

[Ian Pike @ProteomicsIan]

J Buxbaum on protective role of transthyretin in AD. Transthyretin a key plasma and CSF biomarkers from @ProteomeScience #ADPD2015

[Ian Pike @ProteomicsIan]

Great session on ALS/FTD AT #ADPD2015 today. C9orf72 dipeptide repeats seen in CSF may be prognostic marker.

[Ian Pike @ProteomicsIan]

#ADPD2015 day 4 and our last poster. Novel low-abundance markers of Microglial activation are detectable in CSF by next gen proteomics no.70

[Alfonso Martinez Arias @AMartinezArias]

...thinking @ #peereview, always remember: review as you would like to be review. Look for the reasons to publish and improve the manuscript

[Ian Pike @ProteomicsIan]

Day 3 #ADPD2015 and @ProteomeScience has two posters on novel clusterin plasma assay 178 and CK1d inhibitor mode of action 295

[Ian Pike @ProteomicsIan]

If tau fibrils different in individuals better to stop their production. Tau kinase inhibitors may do this early in process #ADPD2015