It's been a while now, but @DrFlashHeart and I are excited to share that our work exploring somatic gene x environment interactions between CHIP and air pollution in lung cancer is now published in @JNCI_Now
https://t.co/qhkmSENvl4
✨ Thrilled to share our new publication in Nature.
We define an “inflammatory memory” HSC state (HSC‑iM), linking lifelong inflammatory exposure to aging and disease.
📄 Article: https://t.co/7OSZ7uNZHi
Grateful to an incredible team and global collaborators 💚💙
New preprint out! We asked: can we tell which CHIP mutations actually matter for disease risk? Analyzing >1 million individuals across @ukbiobank, @AllofUsResearch, and @VUMChealth BioVU — here's what we found. 🧵 (1/9)
Happy International Day of Women & Girls in Science! 🌟 Celebrating the brilliant minds breaking barriers, sparking innovation, & inspiring future generations to dream bigger. Here’s to curiosity, discovery, and the power of science! 💡🔬 #WomenInScience#GirlsInSTEM#IDWGS2026
@rheumrob,@AlexBickMDPhD, & I are excited to share that our work is now out in @jclinicalinvest! CHIP epi studies underestimate the association between CHIP & disease using WGS vs deep sequencing. Many thanks to the co-authors, participants, & reviewers! https://t.co/l2lXYF8EKy
@ArndtVogel@Cancer_Cell Thanks for highlighting.
Some complementary findings by Robert Vanner @pmcancercentre and others:
https://t.co/92w9KMgTIC
https://t.co/7QFWHAeQfx
CHIP was associated with increased heart failure and ischemic cardiovascular disease risk after #cancer therapy in patients with solid tumors, especially among those with higher #chemotherapy exposure. https://t.co/YLirctG8gI
Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice
In this Research Letter, Bowen Yan @BowenyanYan, Olga A. Guryanova @gur_ola@UFHealthCancer @UF_Pharmacolo& team @UFMedicine report #ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and drives the risk of #diabetes and #MASLD in the context of a high-fat #diet: https://t.co/xgZ8s0SgA6
📢 Online today: Ancestry-dependent patterns of somatic mosaicism and clonal hematopoiesis mutations in over 125,000 individuals reveal distinct cancer associations https://t.co/R851rzoiIa. A huge feat with pretty figures, driven by #ChristelleColinLeitzinger. 👏
Happy to share that our work on TET2 CH in ICI therapy is now out in @CR_AACR!
We found that TET2 mutations promote myeloid co-stimulatory programs and suppress T cell exhaustion, contributing to improved immunotherapy response!
🔗Read more here: https://t.co/LFIkhKcWGE
Congrats Alex McDonald on your MSc graduation @tmedQueens ! ! 🎉🍁
You made fundamental discoveries about clonal hematopoiesis and risk of Alzheimer disease, and contributions to this paper @CellStemCell . Amazing!!🤩
https://t.co/4p0kVqtQMG
CHIP variants are often discovered incidentally in liquid biopsy testing, but is plasma cell-free DNA reliable when CHIP variants are the desired finding? 🩸@BloodAdvances@AlexBickMDPhD 🧵1/12
Congrats, Shelley! We also reported @CellRepMed that CH infiltration of solid tumors is associated with poor outcomes and, in a preprint, soon to be published, that TET2-mutant CH enhanced ICT response. Good to see the concordance! @marcobuttigieg_ https://t.co/xGsZf1Hcox
https://t.co/U75hUhFPTE
Congratulations to @PMResearch_UHN's Dr. Robert Vanner, who leads a team awarded $1M through @BrainCanada and @SRC_CRS's 2025 Translational Research Grant in Brain Cancer! 🎉
🔗Learn more about the project focused on advancing #glioblastoma research: https://t.co/TQ2DJoRXg9