Roberto Toro [email protected] r3rt0.bsky.social

Into brains (+open science, procedural art, genomics, music...)

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

Interested in the development of brain folding? We have 2 postdoc positions to study the molecular and mechanical causes of brain folding!
Thread 1: Modelling different hypotheses of brain folding
Thread 2: Multimodal, multi-scale atlas
@BorrellLab @neuroliege @Franze_Lab (1/3)

[katja heuer🦋k4tj4.bsky.social🐘[email protected] @katjaQheuer]

1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @R3RT0 , https://t.co/668msRHMNu

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

@BenjaminLy61243 @katjaQheuer @LFeldmanBarrett thank you! 🙏

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

@caglarag_lar @katjaQheuer should be the case! check the 'epithelial mechanics' group of people in bsky for many examples <3

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

@BenjaminLy61243 @katjaQheuer @LFeldmanBarrett The idea has deep roots! We have a chapter on the Evolution of cortical folding ready to go. We talk a bit about the Developmental Mechanics of Wilhelm His back in ~1844. I'll have to check Bernstein. Any reference in particular? (I started following you on bsky 😋)

[katja heuer🦋k4tj4.bsky.social🐘[email protected] @katjaQheuer]

@nicolas_traut @NeuroecologyLab @BorrellLab @R3RT0 19
Extra bonus: Flight through the whole brain connectomes of the 4 large brained species capuchin, colobus, macaque and mangabey.

[katja heuer🦋k4tj4.bsky.social🐘[email protected] @katjaQheuer]

12
All this suggests that mechanical morphogenesis may be a major 3rd causal determinant of the development and evolution of brain organisation in primates.

[katja heuer🦋k4tj4.bsky.social🐘[email protected] @katjaQheuer]

6
Zoom into illustration #2: New World monkeys like capuchins have much more folded brains than their Marmoset cousins. Surprisingly, their folding pattern is almost identical to that of Old World monkeys like macaques despite ~47my independent evolution—as much as whales&hippos!

[katja heuer🦋k4tj4.bsky.social🐘[email protected] @katjaQheuer]

5
Lining up primate brains solely based on their size provides a 1st striking illustration of the importance of mechanical morphogenesis: despite jumping across far branches of the phylogenetic tree, the sequence is continuous, hinting at a common underlying organising principle.

[Brandon Luu, MD @BrandonLuuMD]

Lifestyle is a stronger predictor of aging and mortality than genetics.

A new Nature study of ~500,000 people found:
🎯 17% of mortality variation was linked to lifestyle (exposome).
🧬 <2% of was explained by genetics.

Here’s what you need to know 👇🧵 1/10

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

@ECaruyer @JakobWasserthal Thank you @ECaruyer for the shoutout :D
We still use https://t.co/EzeD2zOBpX for all our manual segmentation needs. For example, the segmentations for @katjaQheuer's paper on the cortical folding of 34 primate species were all done using BrainBox!
https://t.co/xlKjHo8nUF

[Development @Dev_journal]

Short-range Fgf signalling patterns hindbrain progenitors to induce the neurogenesis-to-oligodendrogenesis switch

Read this #OpenAccess Research Article by Tim Yeung @tim_justina and David Wilkinson @TheCrick:
https://t.co/jD8NcwiFVW

[Laurent Nguyen @neuroliege]

Svante Paäbo has been made Honoris Causa doctor of the University of Liège. Followed by a geeat meeting with him at GIGA on this occasion @GIGA_ULiege @UniversiteLiege @frsFNRS

[@parkvillegeek @ParkvilleGeek]

ping @R3RT0

Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology | bioRxiv https://t.co/Kx4LndtVFx

[QBio (@qbio-ens.bsky.social) @QBio_PSL]

🦠 For the next FRESK seminar on monday, December 9th, we meet Suchismita Das (LPENS) for the next presentation: "Active colloidal matter: flocking and wetting transitions"

https://t.co/PzZxVTSUZm

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

@CandiceCheung12 @institutpasteur We don't have a set deadline. If we find someone, the starting date could be right now!

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

🚨 We’re hiring! 🚨 We're looking for a postdoc for our ERC Synergy project Unfold (https://t.co/SK9mZdyGaN). Join our lab at @institutpasteur to model brain morphogenesis! (1/10)

[laurence melloul @LaurenceMelloul]

Ce vendredi midi, la Caisse des Écoles de Paris Centre adopte le Croc de #notrecafemarais. 🙏à tous ceux qui ont participé à cette initiative et 👏à notre belle équipe Steeve, Nadine et Anastasia en cuisine à l’école de la place des Vosges.
#accessibiliteuniverselle

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

@w40nsk1 @PslQlife @QBio_PSL @AlainGoriely @BrunoLevy01 @katjaQheuer @EpiMechFC Please do Bruno! Thank you very much🙏!

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

Thread 2: Multimodal atlas of brain development (3/3)
https://t.co/jGJNE1CrJ3

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

🧠 Come work with us! Our lab at @institutpasteur
looks for a postdoc to help us create the most complete open atlas of brain folding development! This is part of our ERC Synergy project Unfold (https://t.co/SK9mZdyGaN). Join us! (1/10)

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

Interested in the development of brain folding? We have 2 postdoc positions to study the molecular and mechanical causes of brain folding!
Thread 1: Modelling different hypotheses of brain folding
Thread 2: Multimodal, multi-scale atlas
@BorrellLab @neuroliege @Franze_Lab (1/3)

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

Thread 1: Modelling brain development (2/3)
https://t.co/P35uP8o39e

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

🚨 We’re hiring! 🚨 We're looking for a postdoc for our ERC Synergy project Unfold (https://t.co/SK9mZdyGaN). Join our lab at @institutpasteur to model brain morphogenesis! (1/10)

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

Please repost 🙏 ! @BorrellLab @neuroliege @Franze_Lab @AmyFDHoward @SaadJbabdi @BrunoLevy01 @piloubazin @MichelTdS

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

🧠 Come work with us! Our lab at @institutpasteur
looks for a postdoc to help us create the most complete open atlas of brain folding development! This is part of our ERC Synergy project Unfold (https://t.co/SK9mZdyGaN). Join us! (1/10)

[Roberto Toro [email protected] r3rt0.bsky.social @R3RT0]

📜 Profile: Neuroscientist with a quantitative background (eng/comp sci/maths), with experience working with pixels, voxels and meshes, computational neuroanatomy, programming skills (Python, Javascript) and passion for brain development 🔗 DM for info! Spread the word! (10/10)