RNA

The official journal of the RNA Society. Featuring cutting edge research in RNA Biology, biochemistry, genetics, cell biology, structural biology and genomics

[RNA @RNAJournal]

Nanopore direct RNA sequencing is redefining how we detect RNA modifications, enabling long-read, transcriptome-wide views with minimal RNA handling. This perspective highlights both the power and current limitations of DRS in probing the epitranscriptome https://t.co/fXbNkpq2sr

[RNA @RNAJournal]

How well can machine learning predict RNA secondary structure? This review surveys current approaches—from deep learning to hybrid models—highlighting both impressive gains and key limitations in generalizability and interpretability https://t.co/QrbXZdQsqq

[RNA @RNAJournal]

What does it mean to study RNA at system scale? This Special Issue perspective lays out a roadmap—from quantitative transcriptomics to integrative modeling—defining how we measure, model, and ultimately manipulate RNA across biological systems https://t.co/GFgnkcrGPb
#RNAbiology

[RNA @RNAJournal]

Excited to highlight the new Special Issue of RNA showcasing advances in system-level RNA biology, from epitranscriptomics and RNA damage to deep learning–driven structure prediction and beyond. A strong snapshot of where the field is heading https://t.co/QRNi6RlAtO

[RNA @RNAJournal]

Two amino acids in each homologous PUF repeat make molecular contacts that drive base recognition. These molecular contacts cannot generally be functionally interchanged between repeats, as shown https://t.co/OgVu6qqpLs

[RNA @RNAJournal]

The proteome is dynamically remodeled across the mammalian cell cycle. Here, we review the mechanistic basis and functional consequences of cell cycle-specific mRNA decay and translational control https://t.co/AvmoBxrdzC

[RNA @RNAJournal]

Translation elongation stresses like tRNA synthetase inhibitors induce the stress response but inhibit translation elongation, leading to a parabolic dose-response pattern of stress granule assembly https://t.co/M5PeuqWl2t

[RNA @RNAJournal]

Complementary DNA oligonucleotide direct in-gel quantification (cDINGQ) for precise tRNA fragment analysis https://t.co/rdRbIYXMyB

[RNA @RNAJournal]

In the cytoplasm of neuroblastoma cells, PTBP1 maintains CyCoNP homeostasis by modulating miR-4492 loading, sustaining NCAM1 expression. PTBP1 loss enhances miRNA repression over CyCoNP. #lncRNA https://t.co/R3YzWKvpMu

[RNA @RNAJournal]

eRNAs extend enhancer function beyond transcription. Mapping eRNA decay reveals cytoplasmic eRNAs stabilise mRNAs and boost translation, helping enhancers finish the job they start https://t.co/TDf0Yj2VNj

[RNA @RNAJournal]

MiSiPi.RNA is a software package written in R for the classification of animal small RNAs into major known types: microRNAs (mi), small-interfering RNAs (si), and piwi-interacting RNAs (pi). This comprehensive tool calculates over 20 parameters https://t.co/niWYniPFXS

[RNA @RNAJournal]

Prime positions in sRNA binding sites located in coding sequences are adjusted with the reading frame and often coincide with the most frequent codons https://t.co/svokq00tPg

[RNA @RNAJournal]

Telomeres are transcribed into TERRA. We showed that iTERRA is transcribed from interstitial telomeric repeats (ITSs) and that CpG island subtelomeric promoters are also present at interstitial sites https://t.co/xskJQQYO1z

[RNA @RNAJournal]

Mutation of a conserved amino acid in the Prp8 alpha-finger increases use of non-YAG 3' splice sites in budding yeast and provides insight into Prp22 ATPase function. https://t.co/WmUSKu6L2q

[RNA @RNAJournal]

m⁵C-Rol-LAMP, a simple qPCR-based assay, quantifies m⁵C RNA methylation at single nucleotides and uncovers stress-regulated rRNA modification in bacteria. https://t.co/zxMJSW2Sm9 #LMU_muenchen #lifescimunich #RNA #CRC1309

[RNA @RNAJournal]

Conserved protein Seb1 that interacts with RNA polymerase II and RNA is an anti-pausing transcription elongation factor https://t.co/F7IlBgU8fu

[RNA @RNAJournal]

IsoformMapper creates protein networks from AlphaFold models and uses InfoMap community detection to compare isoform structures and visualize alternative splicing consequences via alluvial diagrams. https://t.co/l83wV0be9V #AlternativeSplicing #RNASplicing

[RNA @RNAJournal]

A genome-wide screen revealed that proteins lacking stable structures can be just as essential as folded ones. Among them, FAM32A plays a crucial role in RNA splicing. @UTokyo_News_en @KotaroTsuboyama https://t.co/gG7aCPo86s

[RNA @RNAJournal]

A PLP-RCA method enables simultaneous, in situ detection of AAV transgene DNA and mRNA at single-cell resolution, enabling the analysis of genome processing and transduction efficiency. https://t.co/6fjQrBbq54

[RNA @RNAJournal]

By analyzing the subcellular localization of various UPF1 mutants, we show that UPF1’s nuclear-cytoplasmic shuttling is independent of its ATPase and RNA binding activities, with RNA binding itself being a key determinant of its cytoplasmic retention. https://t.co/7TjEb5UWTw