Reclaiming women’s & reproductive health & policy with evidence (4100+ articles), education, AI empowerment tools, & innovation.
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Couples think they spent months trying with zero results when conception ACTUALLY happened.
Around half of all fertilized eggs are lost before a missed period. The egg meets the sperm and begins dividing, but biology runs a strict screening process behind the scenes. The embryo can stop before it reaches a healthy blastocyst, or get to the uterus without implanting, or implant briefly and quit before hCG climbs high enough to show up on a pregnancy test.
You might get a delayed period followed by an unusually heavy bleed if that happened, or might have a normal period with no visible signs.
From the inside, your biology is working its selection process hard. Stay positive.
The "pregnenolone steal" theory sounds logical but the mechanism is wrong.
Your body does not run out of pregnenolone because "cortisol used it all up." What happens is that your brain sees high stress or low energy intake as "not safe to reproduce," and turns down the hormonal pulse that triggers ovulation. The hypothalamus stops sending the signal so your ovaries go quiet.
You can take all the pregnenolone supplements you want and it won't override a hypothalamus that believes it's running away from a tiger. The bottleneck is the brain, not the raw material.
If you want to turn the signal back on, fix the stress and the energy deficit.
"Absence of evidence is not evidence of absence."
A clean scan doesn't rule out endometriosis.
Heather Guidone has spent thirty years changing what patients get offered instead.
https://t.co/A6QMPvctvJ
Heather Guidone joined the Save the Uterus Club to talk about what endometriosis advocacy got right and what it got wrong.
"Don't mistake celebrity for credibility. It's not awareness if it's wrong."
https://t.co/VvUHhHlHae
She's not a doctor. The UK Parliament quoted her anyway.
Heather Guidone has spent three decades inside the endometriosis movement. Tomorrow she tells us what awareness fixed, what it didn't, and the mistakes we can't afford to repeat.
A surrogate, believing she was carrying a child for a single father, is actually having a baby for a Chinese billionaire who allegedly has more than 100 kids. CBS News broke the news to her.
Leaked documents obtained by CBS News named the intended father as Xu Bo, a Chinese billionaire and video game executive. Xu Bo has been reported to have over 100 children through U.S. surrogates, granting them American citizenship at birth. A former partner involved in a custody lawsuit against Xu Bo claims he has as many as 300 children. He has disputed these numbers, and has said in a statement that he has custody of 12 children born through surrogacy in the U.S.
CBS News' @KatrinaSari interviewed the surrogate – who we are referring to as "Judy" to keep her identity private – who said she was blindsided to learn about Xu Bo. CBS News spoke to 32 surrogates for an investigation into the industry. Head to the linked article for more on this investigation.
VITAMIN D & EGG QUALITY!
In 252 women going through ICSI, sufficient vitamin D was associated with 1.85x the odds of high quality eggs. I would get it from the sun.
The pace of walking is another important factor of exercise w/r to a link with cardiovascular and all-cause mortality
Summary of findings from @uk_biobank large cohort study https://t.co/ljTTE0oWRJ
PCOS: an adaptation to environmental unsafety?! Fascinating new research suggests that women with PCOS/PMOS may preserve more ovarian follicles/eggs as they age.
If we think of what this means through Dr. Zach Bush perspective (which I adore), perhaps PMOS is holding fertility in a pause: the follicles remain protected even through age, but struggle to mature and ovulate until the body receives stronger signals of metabolic and environmental safety.
Hmmm, I just discovered something very interesting! 1 million women have breast biopsies/year in the US. Often, a permanent marker is left behind so the area can be identified on future imaging. These markers are made of metals...some of titanium, while others are made from nitinol, which are made approx. 50% of nickel.
This raises a question I think deserves more attention:
Why are we permanently implanting nickel-containing materials into breast tissue when metallic nickel is classified by IARC as Group 2B, possibly carcinogenic to humans, and implanted metallic nickel has produced carcinogenic effects in animal studies?
This does NOT mean that breast biopsy markers have been shown to cause breast cancer in women, but if nickel-free alternatives exist, I think women deserve to know exactly what material is being implanted, how much nickel it can release over decades, and whether long-term outcomes have been properly studied.
PCOS: an adaptation to environmental unsafety?! Fascinating new research suggests that women with PCOS/PMOS may preserve more ovarian follicles/eggs as they age.
If we think of what this means through Dr. Zach Bush perspective (which I adore), perhaps PMOS is holding fertility in a pause: the follicles remain protected even through age, but struggle to mature and ovulate until the body receives stronger signals of metabolic and environmental safety.
Ovarian aging and the "leaky gut"
"These findings provide the strongest evidence to date that menopause may promote gut barrier dysfunction
and microbial translocation in otherwise-healthy women." @jclinicalinvest
https://t.co/LhgR0L4yXr