Global reference values reveal total pancreatectomy carries higher complication and mortality risks than pancreatoduodenectomy, especially for cases involving vascular resection. https://t.co/gouCXeDg4p
El p-valor debe interpretarse con cuidado: no nos dice si la hipótesis es verdadera; evalúa la evidencia contra la hipótesis nula; úsalo junto con el tamaño del efecto (e.g. MCID), los intervalos de confianza y el contexto del estudio.
#stats#pvalor#pvalue#DataScience
Los quistes del colédoco son malformaciones congénitas raras, que consisten en la dilatación quística del árbol biliar tanto intrahepático como extrahepático.
PEDIATR. 2 0 1 6;4 9(2):64–67
Hola🤠 Cuando tu variable depende de una respuesta binaria (sí/no, 0/1), la #regresiónLogística en #R te permite estimar probabilidades 📊
🚩Te dejo este ejemplo paso a paso y con código reproducible:
🔗https://t.co/cfpV75awmr
#CódigoDeTodxs
¿Está interesado en escribir un artículo científico?
Manual de redacción científica le mostrará paso por paso cómo lograrlo #Ciencia
https://t.co/rYboR9H6z7
Noninvasive Assessment of Liver Fibrosis (NEJM 2025)
🔍 Key Concepts
The extent and progression of liver fibrosis define the prognosis in chronic liver disease.
Early detection of fibrosis before cirrhosis develops changes outcomes and enables prevention strategies.
⚙️ Revolution in Hepatology
Noninvasive fibrosis tests have replaced liver biopsy in most cases.
They help diagnose, stage, and risk-stratify patients with chronic liver disease.
Also useful for predicting cirrhosis-related complications.
🧠 Main Tools in Practice
FIB-4 Index – Simple, inexpensive; ideal for primary care and diabetes clinics.
Enhanced Liver Fibrosis (ELF) Score – Specialized serum test with high accuracy.
Transient Elastography (VCTE / FibroScan®) – Measures liver stiffness through vibration-controlled technology.
Magnetic Resonance Elastography (MRE) – Most accurate, but costly and limited to tertiary centers.
📊 Practical Clinical Pathway
Begin with FIB-4 using age, AST, ALT, and platelet count.
If FIB-4 < 1.3, advanced fibrosis is unlikely—manage risk factors and recheck periodically.
If FIB-4 ≥ 1.3, perform VCTE or ELF.
If noninvasive tests show high stiffness or score, refer to a hepatology clinic for confirmation or management.
⚠️ Important Confounders
FIB-4 may give false positives in older adults (>65 years).
ELF can rise due to inflammation unrelated to liver disease.
VCTE accuracy is reduced in obesity, recent meals, or high ALT levels.
FibroTest can be misleading in hemolysis or Gilbert’s syndrome.
💰 Cost and Context
FIB-4 – Cheapest, universally applicable.
ELF – Moderately expensive, more specialized.
VCTE – Intermediate cost, widely available in liver clinics.
MRE – High cost, limited availability but top precision.
💡 Key Clinical Insights
Use noninvasive fibrosis testing routinely in patients with diabetes, obesity, metabolic syndrome, or unexplained elevated liver enzymes.
Sequential testing (FIB-4 → VCTE/ELF) avoids unnecessary liver biopsy.
Helps detect silent MASLD/MASH early in primary care and diabetology settings.
Raising awareness among non-hepatologists is critical for early screening and prevention.
🧩 CME INDIA Take-Home Message
“Use FIB-4 in primary care, FibroScan in specialty care — a biopsy-free pathway to detect silent liver fibrosis before it’s too late.”
https://t.co/SlInerlZkI