Ruidong Xiang

Research Leader Computational Biology @DEECA_Vic @VicGovAg | visiting researcher @CamBakerSGI | @BakerResearchAu | @UniMelb | Views my own

[Ruidong Xiang @RXiang5]

A layman digest of our recent paper “Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping” https://t.co/zl4EZVbPiR

[Ruidong Xiang @RXiang5]

Here we propose a new framework called “Functional-And-Evolutionary Multi-trait Importance (FAEMI) score”. Developed using a Bayesian method, we collected and analyzed annotation and omics data across multiple consortia, converting more than 2.3 millions of molecular phenotypes.

[Ruidong Xiang @RXiang5]

Massive multi-omics data are generated to annotate animal genomes. However, how to use these datasets to improve genomic prediction and mapping is not clear. More importantly, how to use these datasets to improve agriculture in the changing climate is not understood.

[Ruidong Xiang @RXiang5]

Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping | PNAS https://t.co/6wIDaSKGuH

[Ruidong Xiang @RXiang5]

Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping | PNAS https://t.co/6wIDaSKGuH

[Ruidong Xiang @RXiang5]

GSOR is validated by applying it to milk lipid traits in cattle, led by Ghoreishifar et al, and they identify potentially causal genes and pathways linked to milk composition: https://t.co/qeCGfaHI35

[Ruidong Xiang @RXiang5]

GSOR is validated by applying it to milk lipid traits in cattle, led by Ghoreishifar et al, and they identify potentially causal genes and pathways linked to milk composition: https://t.co/qeCGfaHI35

[Ruidong Xiang @RXiang5]

Estimated Breeding Value(EBV) or Polygenic Score(PGS) cal using genome-wide SNPs. We propose calculate EBV or PGS near genes - cis or local EBV/PGS to assoc with assayed gene expression to prioritise genes and tissues: Genetic score omics regression (GSOR)https://t.co/CJBMNJrrBs

[Ruidong Xiang @RXiang5]

Estimated Breeding Value(EBV) or Polygenic Score(PGS) cal using genome-wide SNPs. We propose calculate EBV or PGS near genes - cis or local EBV/PGS to assoc with assayed gene expression to prioritise genes and tissues: Genetic score omics regression (GSOR)https://t.co/CJBMNJrrBs

[Ruidong Xiang @RXiang5]

We collaborated on analysing MRI imaging data from the UK Biobank, found that visceral adipose tissue (abdominal fat) has stronger links to venous thromboembolism (blood clot) than BMI. Publication: https://t.co/gFVDVbZoBV

[Ruidong Xiang @RXiang5]

We collaborated on analysing MRI imaging data from the UK Biobank, found that visceral adipose tissue (abdominal fat) has stronger links to venous thromboembolism (blood clot) than BMI. Publication: https://t.co/gFVDVbZoBV

[Ruidong Xiang @RXiang5]

Complex trait analyses usually focus on trait means. We analysed trait variances in human blood cell phenotypes, yielding new biological/clinical insights: trait variation strongly negatively selected, impact polygenic score accuracy and highlights the effect of alcohol on health

[Ruidong Xiang @RXiang5]

Further reading: Further reading: https://t.co/umWvUDQ1as

[Ruidong Xiang @RXiang5]

Further reading: Further reading: https://t.co/umWvUDQ1as

[Ruidong Xiang @RXiang5]

Complex trait analyses usually focus on trait means. We analysed trait variances in human blood cell phenotypes, yielding new biological/clinical insights: trait variation strongly negatively selected, impact polygenic score accuracy and highlights the effect of alcohol on health

[Lingzhao Fang @LingzhaoF]

Thrilled to share that the pilot ChickenGTEx resource is online at Nature Genetics now ⁦@NatureGenet⁩ . Congratulations to all the collaborators. Looking forward to more scientific outcomes from the FarmGTEx. https://t.co/snKE60vf1N

[Ruidong Xiang @RXiang5]

Exciting global efforts to discover and use regulatory variants (eg, eQTLs, sQTLs) to enhance agriculture, evolution and biomedicine! Further reading for our pioneer work in Cattle GTEx: resource 👉https://t.co/TyHVZNDKYv; trait heritability dissection 👉https://t.co/AGPUWvnJ1f

[Ruidong Xiang @RXiang5]

Exciting global efforts to discover and use regulatory variants (eg, eQTLs, sQTLs) to enhance agriculture, evolution and biomedicine! Further reading for our pioneer work in Cattle GTEx: resource 👉https://t.co/TyHVZNDKYv; trait heritability dissection 👉https://t.co/AGPUWvnJ1f

[Lingzhao Fang @LingzhaoF]

Thrilled to share that The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project perspective paper is out ⁦@NatureGenet⁩. Thank all the authors for the efforts and supports. Looking forward to seeing amazing science coming from this initiative. https://t.co/kwd9ApoC0W

[David MacHugh @david_machugh]

Great to see the Farm Animal Genotype–Tissue Expression (#FarmGTEx) Project perspective article published in @NatureGenet. A fantastic #livestock #FunctionalGenomics project led by @LingzhaoF at @AarhusUni_int.

https://t.co/HVtH4In3i5

[Lingzhao Fang @LingzhaoF]

Thrilled to share that The Farm Animal Genotype–Tissue Expression (FarmGTEx) Project perspective paper is out ⁦@NatureGenet⁩. Thank all the authors for the efforts and supports. Looking forward to seeing amazing science coming from this initiative. https://t.co/kwd9ApoC0W

[Ruidong Xiang @RXiang5]

One of it’s kind: sheep multi-tissue developmental gene expression atlas (dGEA) https://t.co/KNBCFveMqx ; global collaboration across EU, China, Australia and US! @emilylouise221 @LingzhaoF