Robert Appleby

Postdoc at the Crick, structural biology and DNA damage repair.

[Costanzo’s Lab @LabVincenzo]

See our new paper! CryoEM reveals RAD51 binds and protects abasic sites. We also show abasic DNA gaps and MRE11 dependent fork breakage without BRCA2/RAD51 from SMUG1, APOBEC3, TET2, and DNMTs. Major implications. Stunning structures with @PellegriniLab

https://t.co/corCnN3paN

[Robert Appleby @Rapp1eby]

Time for my yearly tweet…our paper has just been published in @MolecularCell ! A lovely collaboration and a great mix of cell biology, biochemistry, biophysics and #cryoEM showing a new role for human RAD51 in binding and protecting abasic DNA 🧬

https://t.co/jDWtjtv6Fg.

[Robert Appleby @Rapp1eby]

The RAD51:BRCA2 #cryoEM structures from our recent paper (https://t.co/lXV72HMwWY) are now on the PDB! @EMDB_EMPIAR deposition following soon…

https://t.co/s91FJzhibD

[Robert Appleby @Rapp1eby]

Delighted to have our paper on RAD51 filament binding by BRCA2 published a couple of days ago! @PellegriniLab #cryoEM https://t.co/lXV72HMwWY