Rotterdam Thyroid Center

Basic, translational and epidemiological research center for all thyroid, and thyroid-related disease | Erasmus MC | Rotterdam

[Rotterdam Thyroid Center @Rdam_Thyroid_C]

@fperrywilson @JAMA_current @threadreaderapp unroll

[Tim Korevaar @TimKorevaar]

In our latest study from the Consortium on Thyroid and Pregnancy, Sofie Bliddal quantified the association of thyroid antibodies with gestational TSH and FT4 and shows that the association of TgAbs with TSH or FT4 is only driven by concomitant TPOAbs.

https://t.co/WmeA8bLr0b

[Tim Korevaar @TimKorevaar]

Great talk by Arash Derakhshan showing how human epidemiological studies can be used to translate experimental study results and how the combination of different types of data is key to move forward.

Next step, an EDC consortium!
#ECE2022 #EuropeanHormoneDay @ESEndocrinology

[Tim Korevaar @TimKorevaar]

#EuropeanHormoneDay is 1 day after #WorldPreeclampsiaDay.

A brilliant coincident to remind us that many endocrine disorders are associated with a high risk of preeclampsia, often an indication for aspirin prophylaxis!

@ESEndocrinology @ISUOG #ECE2022 https://t.co/A1lbPwijJ9

[Tim Korevaar @TimKorevaar]

If you missed the fantastic presentation on parathyroid disorders in pregnancy at #ECE2022, make sure to check the recording. Even the overflow room was packed! @BotcentrumLUMC @LUMC_Leiden
@ESEndocrinology
https://t.co/dZ1Ne8YKPU

[Maria Papaleontiou, MD @MariaPapaleont1]

Check out this hot issue in thyroidology guest edited by myself and Megan Haymart now in press! https://t.co/pcFE6ds3t7. Thank you @AngelaLeung9 @TimKorevaar @DrAKotwal @susieQP8 and many others for excellent contributions!

[Tim Korevaar @TimKorevaar]

Out now and free to read: Diagnostic and Treatment Considerations for Thyroid Cancer in Women of Reproductive Age and the Perinatal Period

https://t.co/ro0R3rRfOm

Great collaboration with @AngelaLeung9
Evert v Velsen

[Euro J Endocrinology @EJEndo]

New research from @Rdam_Thyroid_C, evaluating the use of a two-step age-based cutoff for the UICC/AJCC TNM staging system in patients with papillary or follicular #thyroid cancer by Evert F S van Velsen et al.

https://t.co/SAYj897aWn

[Tim Korevaar @TimKorevaar]

3 days left to help us out!

[Tim Korevaar @TimKorevaar]

Another cool collaborative effort from the Consortium on Thyroid and Pregnancy, this time led by @FJKToloza and @endofellow.

Again results pointing towards a dose-response risk association at the outskirts of the normal range.

@TheLancetEndo @TheLancet #thyroid #pregnancy

[Tim Korevaar @TimKorevaar]

Check out our interpretation of the new meta-analysis on thyroid function changes during controlled ovarian hyperstimulation, food for thought! @KeyserToke

Controlled ovarian hyperstimulation as a stress test for the thyroid.
https://t.co/X96XzWqnZx

[Tim Korevaar @TimKorevaar]

Following yesterday's @ESEndocrinology postgraduate course on gestational endocrinology:
I wanted to share one of the questions and a quick update on a the strategy to limit antithyroid drug exposure in pregnancy (that is still fairly unknown).

[Tim Korevaar @TimKorevaar]

Just read the outstanding study by Irina Bancos et al on:

Pheochromocytomas in pregnancy

A thread!
Based on my fascination for pheochromocytomas, obstetric medicine and these new data.

pic=malignant paraganglioma+fetus https://t.co/ZLsoag3xE3
paper: https://t.co/PAccrm3i6j

[Tim Korevaar @TimKorevaar]

How about that grey zone?

Guidelines: consider treatment, individualize

Think about:
- Abnormal physiology: subhypo despite high hCG (twin, 8-11 wks)
- High TSH
- High-normal TPOAb titer (https://t.co/SnGVYaMAPk)
- High pretest probability of subhypo related adverse outcomes

[Tim Korevaar @TimKorevaar]

If you decide to treat:

Beware of overtreatment!

High FT4 associated with lower birth weight, child IQ and cerebral gray mass (fig).

For example start with 50ug daily and titrate after 2-4 weeks

[Tim Korevaar @TimKorevaar]

Subclinical hypothyroidism during pregnancy:

* Reflects an abnormal physiology
* Use correct reference ranges to diagnose
* Risk stratify: TPOAbs, gestational age etc.
* If you treat ➡️ Don’t overtreat

[The Lancet Diabetes & Endocrinology @TheLancetEndo]

Research Article: Disease characteristics of #MCT8 #deficiency : an international, retrospective, multicentre cohort study

https://t.co/E571L58EsL

[European Society of Endocrinology (ESE) @ESEndocrinology]

Check out our recent blog article with gestational endocrinology expert, Dr @TimKorevaar to learn more about his fascinating research and what he will be presenting at #eECE2020. https://t.co/Jzbcap9kYl

[Tim Korevaar @TimKorevaar]

I am quarantined in London, so #Tweetorial time💂‍♂️⏰

Should we treat subclinical hypothyroidism during pregnancy?

A tweetorial on physiology, overdiagnosis, risk stratification and treatment harms.

Do you treat subclinical hypothyroidism during pregnancy?❌✅

[Rotterdam Thyroid Center @Rdam_Thyroid_C]

Groeneweg et al describe the disease characteristics of MCT8 deficiency in 151 patients from 47 hospitals worldwide.

This study reveals very poor survival with a high prevalence of treatable underlying risk factors.

https://t.co/1lGKFbG37S

@TheLancetEndo @TheLancet @ErasmusMC