ReadCrystal Biotechnology

Structure Determination Expert | The official account of ReadCrystal Biotechnology| Please contact with 📧 [email protected]

[Chem-Station @chemstation]

ReadCrystalが世界に先駆け構築したMicroEDプラットフォームで、微小結晶の構造解析が可能に！X線・クライオEMも含めて最適な解析手法を選択し、低分子化合物・タンパク質・新規素材などの立体構造を明らかにします。構造生物学エキスパート集団が、あなたの創薬・材料開発研究をサポート！#構造解析 #MicroED #CryoEM #X線回折
URL：
https://t.co/ycwEQrD4BV

[ReadCrystal Biotechnology @ReadCrystalTech]

BTK protein is a member of the TEC family of non-receptor tyrosine kinases in the cytoplasm and plays a crucial role in the growth, development, proliferation, and differentiation of B cells. It is also a therapeutic target for B-cell malignancies.
https://t.co/8PA13e20qO

[ReadCrystal Biotechnology @ReadCrystalTech]

BTK protein is a member of the TEC family of non-receptor tyrosine kinases in the cytoplasm and plays a crucial role in the growth, development, proliferation, and differentiation of B cells. We has completed structural analysis of the BTK target protein.
https://t.co/A9cbQi8W4c

[ReadCrystal Biotechnology @ReadCrystalTech]

@ReadCrystalTech has successfully expressed, purified, and crystallized the 38-427 fragment of the Cbl-b protein, which includes the TKB, LHR, and RING domains. We has shortened turnaround time to 1-2 months.
Gallery structure: https://t.co/Xc4REAZvVd

https://t.co/hWweHE98Bm

[ReadCrystal Biotechnology @ReadCrystalTech]

@CancerWithEdu Thank you for your insightful comment! We're delighted to see the innovative research on CO2 reduction being recognized. And we're proud that our microED technology played a key role in revealing these structural details😀

[ReadCrystal Biotechnology @ReadCrystalTech]

Electrolyte Fine-Tuning Alters MOF Catalyst's CO2 Reduction Selectivity, MicroED Reveals MOF Structure
We collected a total of 11 datasets. The four best-quality datasets were selected for combined processing, completing the structure resolution in 4 days.
https://t.co/U08pGnCzTD

[ReadCrystal Biotechnology @ReadCrystalTech]

Structural analysis are the core business of ReadCrystal. Relying on advanced equipment and rich experience, we has built a comprehensive technology platform. Utilizing X-ray Diffraction, CryoEM-SPA, and MicroED, we provide high-quality, one-stop services.
https://t.co/JUV4Jx7N5z

[ReadCrystal Biotechnology @ReadCrystalTech]

MicroED achieves nearly the same high resolution as X-ray crystallography,but requires single crystal samples only at the nanometer scale. This reduction in sample size greatly decreases the difficulty and time needed for protein single crystal cultivation.https://t.co/5Z30p8zcct

[ReadCrystal Biotechnology @ReadCrystalTech]

@ReadCrystalTech has completed the protein expression and structural analysis of multiple KRAS mutation targets. Based on experimental conditions and available protein inventory, we has shortened the turnaround time to 1-2 months.
https://t.co/lyNrNt4w1m

[ReadCrystal Biotechnology @ReadCrystalTech]

@ReadCrystalTech, with structural biology at its core, is committed to elucidating the mechanisms of interaction between target proteins and drug molecules.

Leveraging X-ray, Cryo-EM SPA, and MicroED, we has accumulated protein structure data.

https://t.co/uMBgbT72bV

[ReadCrystal Biotechnology @ReadCrystalTech]

Delve into the intricate world of drug discovery where structural biology plays a pivotal role. At @ReadCrystalTech, we're committed to advancing drug discovery through a deep understanding of protein structures.

For more information, click here: https://t.co/epSTWRE0q9

[ReadCrystal Biotechnology @ReadCrystalTech]

@ReadCrystalTech specializes in providing over 100 high-purity, pre-made target proteins, accelerating your timeline for crystallography and functional studies.

Need a protein tailored to your exact specs? Our team delivers customized plasmid designs.

https://t.co/nh8AY3CVZt

[ReadCrystal Biotechnology @ReadCrystalTech]

Many unknown structures in MOFs and COFs have been analyzed through MicroED technology. MicroED can further test materials such as proteins, peptides, and small drug molecules.

For more information, visit the link: https://t.co/eRkiETAAD8…

#MicroED #MOFs #PorousMaterial

[ReadCrystal Biotechnology @ReadCrystalTech]

MicroED Technology-Enabled Diffusion Rate Sieving of Propylene and Propane in PCPs Published in "Nature Communications". @ReadCrystalTech was responsible for the structural analysis work.

For more information, visit the following link: https://t.co/jCMHoLI8Ml

#MicroED #PCPs

[ReadCrystal Biotechnology @ReadCrystalTech]

ReadCrystal family gathered for an exhilarating team-building event. The event reinforced our values of courage in adversity and relentless pursuit of excellence.

@ReadCrystalTech specializes in structure determination.
Learn more: https://t.co/nh8AY3CVZt
#TeamBuilding #MicroED

[ReadCrystal Biotechnology @ReadCrystalTech]

Great News❗Mastering Chirality with MicroED - the Analysis of Absolute Configuration of Small Molecules

For more information, visit the following link: https://t.co/SaLCtSlLJM

#MicroED #chirality #StructureDetermination #StructureAnalysis #AbsoluteConfiguration #SmallMolecule

[ReadCrystal Biotechnology @ReadCrystalTech]

Advantage of Cryo-EM SPA:
Crystallization-free
1mg sample required
Samples in a near-native hydrated state

@ReadCrystalTech
200 + Protein Targets Expressed
300 + Drug Molecules Structures Solved
500 + Protein Complex Structures Solved
https://t.co/nh8AY3CVZt

[ReadCrystal Biotechnology @ReadCrystalTech]

Imine Reductase: X-ray Crystallography Insights

Due to the absence of highly homologous enzyme structures for reference, @ReadCrystalTech employed de novo phasing to deliver the structural data of the enzyme.

The full case study: https://t.co/UhJmG98Sd2
#StructuralBiology

[ReadCrystal Biotechnology @ReadCrystalTech]

X-ray Diffraction:Accelerating Protein Structure Discovery

With over 500 partners and success in studying 200+ target proteins, @ReadCrystalTech promises fast results in 1-2 months and flexible pricing to fit your needs
For more information, click here
https://t.co/nh8AY3CVZt

[ReadCrystal Biotechnology @ReadCrystalTech]

About MicroED Tech
Atomic details can be extracted from Crystals as small as 100 nm, even in a heterogeneous mixture

Required sample as low as 1 mg

For biological macromolecular crystals (proteins/RNA), drug discovery, chemistry and materials (MOF, etc.)
https://t.co/nh8AY3CVZt