Rob

[Rob @Readthedocument]

The Internet of Bio-Nano Things (IoBNT), introduced by Ian F. Akyildiz and colleagues in 2015, A concept that extends the Internet of Things (IoT) into the biochemical domain of living systems. https://t.co/tkgdU89Pms
.
VIDEO WEBINARS: https://t.co/MtNsmnmwbG

[Rob @Readthedocument]

Dr. James Giordano: Battlescape Brain: Military and Intelligence Use of Neurocognitive Science 2020 https://t.co/KPaw1yezTv

[Rob @Readthedocument]

Dr. James Giordano: Battlescape Brain: Military and Intelligence Use of Neurocognitive Science 2020 https://t.co/KPaw1yezTv

[Rob @Readthedocument]

They finnaly said it!
"It's not a vaccine" 😂

COVID-19 DARPA
https://t.co/JulwA0fMR1

[Rob @Readthedocument]

DATA CENTERS TOKENIZATION OF YOUR BODY FOR U.B.I. IN THE 6G NETWORK https://t.co/7a9n0NFIyT 25 YEAR LONG AGENDA COMPLETED! https://t.co/0xPviHPx2x

[Rob @Readthedocument]

'Answer The FUC***G Question & Resign': Rep. Dean Grills Secy Lutnick Over Epstein 'Lies' https://t.co/lEk1b2v52A

[ITU Development @ITUDevelopment]

One week to #ITURDF for the Americas

Following #WTDC-25, regional stakeholders will come together to discuss implementation, partnerships and practical action to advance the 2026–2029 Regional Initiatives for the Americas.

Register now: https://t.co/6W8zjas0mm

[ITU Development @ITUDevelopment]

📢 New in #ITUAcademy!

Build skills for a more inclusive, informed, and connected digital future with courses on web accessibility, ICTs for ageing, radio signals and health, and evidence-based digital policies.

🎓 Start learning 👉 https://t.co/R8rN3gOSkO

[UN Office for Digital and Emerging Technologies @ODET_UN]

The countdown has begun. In one month, Geneva hosts the inaugural Global Dialogue on Artificial Intelligence Governance.

Registration closes 25 June.

🔗 Register: https://t.co/JUdNHpk7Qj

@ODET_UN @itu @UNESCO

[UN Office for Digital and Emerging Technologies @ODET_UN]

Written inputs to the Global Dialogue on AI Governance from Member States and stakeholders are now published ahead of the inaugural 6–7 July Dialogue. 1,500+ contributions received March–May.

🔗https://t.co/naEHqsDsbn

@ODET_UN @ITU @UNESCO

#AIDialogue #DigitalCooperation

[UN Office for Digital and Emerging Technologies @ODET_UN]

Science and policy converge on AI governance for the first time. On 6-7 July in Geneva, the Independent Panel presents and all 193 Member States deliberate.

🔗 https://t.co/9g9KPfi0VF

#AIDialogue #DigitalCooperation #AIGovernance
@ODET_UN @ITU @UNESCO

[RemnantReady @donotconform2]

@ucworkroom1 @ChildrensHD @thackerpd @NIH And...
Seed priming with silicon quantum dots promotes maize seedling establishment in coastal saline soil
https://t.co/u8ef3umXy7

[Ryan sikorski @Ryansikorski10]

SynHG (Synthetic Human Genome)

SynHG is aiming to develop the foundational & scalable tools, tech & methods needed to synthesise human genomes.

https://t.co/I6yxgDpiL6

Constructive Bio

Uses the world’s first fully synthetic recoded organism to produce therapeutics w/ chemistries that natural biology cannot access.

https://t.co/AfHXJRJvw9

Genetic Code Expansion Platform

The platform enables fermentation-based production of peptides & proteins containing hundreds of non-canonical amino acids.

Transform natural cells into programmable biofactories w/ expanded chemical capabilities.

https://t.co/G55li50XaV

BioForge

Constructive Bio’s industrial fermentation platform for manufacturing peptide & protein therapeutics containing up to 3 different non-canonical amino acids per molecule.

https://t.co/4WdJO2YGFu

Non-canonical amino acids (ncAAs)

ncAAs expand the chemical properties available to peptides & proteins beyond the 20 standard amino acids.

BIOLOGY GIVES U 20 BUILDING BLOCKS. WE GIVE U HUNDREDS MORE!

We engineer orthogonal aminoacyl-tRNA synthetases (aaRS) that selectively charge non-canonical amino acids onto dedicated tRNAs. These engineered aaRS–tRNA pairs work alongside the cell's native translation machinery w/out cross-reacting, enabling site-specific incorporation of ncAAs into peptides & proteins during standard fermentation.

https://t.co/jfa0bVsYCo

Pipeline

The pipeline applies the platform to novel peptide & protein therapeutics, from discovery to clinic.

Enabling robust, reliable bioproduction w/ our phage-resistant Syn61 platform for industrial-scale manufacturing.

Our Syn61 chassis provides inherent resistance to bacteriophage contamination, a critical advantage for industrial biomanufacturing where phage infection can cause catastrophic production failures.

https://t.co/UyBfCNHkfk

Publications

https://t.co/CPFsGonsjk

By combining fully synthetic genomes w/ precisely engineered genetic codes & orthogonal translation machinery, his teams are enabling cells to synthesise entirely new classes of molecules: polymers w/ properties unattainable by natural chemistry, sequence-defined non-canonical biopolymers, & therapeutics that operate far beyond the limits of ribosomal biosynthesis as we know it.

At the heart of the discussion stands Syn61 – now widely regarded as one of the landmark achievements in the history of genome engineering. Syn61 was the clearest demonstration to date that life can be liberated from the universal code that has governed biology for billions of years. It was followed by Syn57. Thru meticulous, genome-wide recoding, Chin’s team compressed the canonical 64-codon genetic code into a streamlined 57-codon framework. As a result, Syn57 is THE LARGEST DELIBERATE REWRITE OF A LIVING GENOME EVER ACCOMPLISHED.

As Chin explains, Syn61 & Syn57 are more than a technical tour de force – they demonstrate the foundational platform for a new era of biological programming. FREED CODONS CAN NOW BE REASSIGNED @ WILL, OPENING VAST CHEMICAL SPACE FOR INCORPORATING NON-CANONICAL AMINO ACIDS, creating genetic firewalls, & ultimately DESIGNING ORGANISMS WHOSE BIOCHEMISTRY OPERATES UNDER RULES WE DEFINE.

https://t.co/cXHPcCPY88

The tech begins w/ assembling large, synthetic DNA fragments that replace megabase-scale sections of an organism's natural genome. W/in these synthetic DNA constructs, specific redundant genetic codons are entirely removed. This frees up those codons & their associated cellular machinery—such as tRNAs & aminoacyl-tRNA synthetases. By introducing new tRNAs & synthetases, the cell's translational system is re-purposed to recognize these free codons & assign them to entirely new, non-natural monomers.

The result is a "recoded" organism capable of sustainably building unique polymers @ scale, extending far beyond nature's standard 20 amino acids. These non-canonical polymers can be endowed w/ enhanced properties in new materials & therapeutics.

https://t.co/TwLcW83mqG

[Ryan sikorski @Ryansikorski10]

“At Constructive Bio we rewrite life's code to turn cells into sustainable bio factories.”

Syn61

https://t.co/1O3KvSVlM4

Syn61 is a fully synthetic, genomically recoded strain of E. coli bacteria developed by researchers @ the MRC Laboratory of Molecular Biology. By rewriting the 4-million base-pair genome, scientists removed 3 of the 64 genetic codons (TCG, TCA, & TAG) & replaced them w/ synonyms, freeing up those codons to encode non-canonical amino acids.

https://t.co/Jcf10EE7E1

Syn61 serves as the technological foundation for commercial platforms like Constructive Bio, which utilizes these recoded bacterial strains as programmable biofactories. The platform is used for large-scale fermentation-based production of complex molecules.

https://t.co/ljCKIWKH5n

Additionally, specific laboratory strains of Syn61 are actively used in academic research & are available to the scientific community via repositories like Addgene.

Syn61Δ3(ev5)

From the Syn61 strain (Addgene #174513), 2 rounds of parallel mutagenesis & dynamic selection were followed by deletion of the serT, serU & prfA genes, & a further 3 rounds of parallel mutagenesis & dynamic selection yielded Syn61Δ3(ev5) (Addgene #174514).

https://t.co/7giXTUe1QJ

Syn61Δ3(ev5) ΔrecA (ev1)

Laboratory adapted, genomically recoded E. coli strain w/out TCG, TCA, or TAG codons & deleted serT, serU, prfA, & recA genes. Evolved for ~270 generations in LB @ 37 °C.

https://t.co/NWvKEvAXa0

Syn57

Syn57 is a radically engineered strain of E. coli bacteria w/ the most compressed & heavily recoded genetic code ever created. While Syn61 removed three codons from the standard 64-codon universal genetic code, Syn57 pushes the boundaries further by eliminating 7 codons, forcing the organism to function using only 57.

To build Syn57, researchers systematically rewrote a 4-megabase E. coli genome to replace 105,000 specific genetic targets.

They altered:

🔸Four Serine codons (compressing the standard 6-codon serine block down to 2)

🔸Two Alanine codons (compressing the standard 4-codon alanine block down to 2)

🔸The Amber stop codon (TAG, replaced by TAA)

Every single instance of these 7 codons across the entire genome had to be substituted w/ a biological "synonym" while keeping the bacteria completely alive & functioning.

https://t.co/H9kh7Kd75e

Design, synthesis, & testing toward a 57-codon genome

https://t.co/IPDeEqnqlS

pYES1L-URA

(Empty Backbone) E.coli shuttle vector for large-scale DNA assembly in S. cerevisiae.

https://t.co/JxKbvLG1TR

Transplant of human chromosomes marks first step in genome synthesis project

This new research paper outlines this pipeline & demonstrates the critical first step in it:

https://t.co/IuKK3FUoZ7

The transplantation of human chromosomes into an ‘assembly cell’, exemplified by a mouse embryonic stem cell (mESC). In the mESC the human chromosome can be manipulated & recoded w/out the complexities of working directly in a human cell, which contains two copies of each chromosome. The isolated chromosome can then be transferred back from the mESC to a recipient human cell & the corresponding ‘spare’ copy eliminated from the recipient, leaving the usual 2 copies. Crucially, the team demonstrated that this can be achieved w/out chromosome damage.

In future work, this ‘assembly cell’ stage of the pipeline WILL BE UTILISED TO REWRITE THE GENETIC INFORMATION ON THE HUMAN CHROMOSOME W/ SYNTHETIC SEQUENCE.

This work was funded by the Wellcome Trust & the UK Medical Research Council w/ additional support from the Boehringer Ingelheim Fonds, the Cambridge Commonwealth, European & International Trust & Marie Skłodowska-Curie Actions.

https://t.co/tVTdkzb8Rp

An adaptable, plug-and-play application of genetic code expansion (GCE) technology for the rapid, modular creation of bispecific nanobody conjugates from non-canonical amino acid (ncAA)- integrated nanobody domains, offering precise control over domain topology.

https://t.co/lsZrrmZ0jB

[Kim @Kwells04Wells]

EarthCARE
Atmospheric LiDAR

European Space Agency

https://t.co/JByTTf0yfw

[Kristie Iushkova 🌺 @KristieIushkova]

🚨Gradually acclimate the public to disruptive or controversial technologies through commercialized, high-visibility proxies🚨🎯
NOTE: ITU’s AI for Good Soft Robotics Source link ⬇️

[Rob @Readthedocument]

Norman Bates is back on the scene and in the spotlight!

[Justin Trudeau @JustinTrudeau]

Sometimes supportive boyfriend duties call. But you know who I’m rooting for to take the Cup 🇨🇦

[Rob @Readthedocument]

THANK YOU COME AGAIN!

⚠️
https://t.co/0xPviHPx2x

[Rob @Readthedocument]

The Internet of Bio-Nano Things (IoBNT), introduced by Ian F. Akyildiz and colleagues in 2015, A concept that extends the Internet of Things (IoT) into the biochemical domain of living systems. https://t.co/tkgdU89Pms
.
VIDEO WEBINARS: https://t.co/MtNsmnmwbG

[Rob @Readthedocument]

STOP LISTENING TO THESE PAID INFLUENCERS!

TURN THEM OFF!

WHAT FRAUD LOOKS LIKE!! DR GROUP AND DR ANA BRAGING ABOUT THE GOLD NANOPARTICLES IN DR GROUPS METHYLENE BLUE PRODUCT https://t.co/4CWMS8zZfQ
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⚠️
Dr. Edward Group AI WELNESS
https://t.co/qXXq21DBmk

[Rob @Readthedocument]

The Internet of Bio-Nano Things (IoBNT), introduced by Ian F. Akyildiz and colleagues in 2015, A concept that extends the Internet of Things (IoT) into the biochemical domain of living systems. https://t.co/tkgdU89Pms
.
VIDEO WEBINARS: https://t.co/MtNsmnmwbG

[Rob @Readthedocument]

united Kingdom biodigital convergence https://t.co/BA3lgZhHjg

[Rob @Readthedocument]

The Internet of Bio-Nano Things (IoBNT), introduced by Ian F. Akyildiz and colleagues in 2015, A concept that extends the Internet of Things (IoT) into the biochemical domain of living systems. https://t.co/tkgdU89Pms
.
VIDEO WEBINARS: https://t.co/MtNsmnmwbG

[Rob @Readthedocument]

Winnipeg police warn of extremist online groups targeting children June 12, 2026
https://t.co/jhn9IUwXd5

[Rob @Readthedocument]

The Internet of Bio-Nano Things (IoBNT), introduced by Ian F. Akyildiz and colleagues in 2015, A concept that extends the Internet of Things (IoT) into the biochemical domain of living systems. https://t.co/tkgdU89Pms
.
VIDEO WEBINARS: https://t.co/MtNsmnmwbG

[Privacy International @privacyint]

Facial recognition is entering classrooms and campuses.
We are tracking its spread and impact on privacy rights.
https://t.co/giyTkFusJV