This innovation opens up exciting possibilities for studying T cell biology in depth, shedding light on how these cells work in health and disease. It also paves the way for the development of future immunotherapies that harness the power of light. 🌞 #LiTESystem#Immunotherapy
We are thrilled to introduce the groundbreaking technology called the Light-inducible T cell Engager (LiTE) system. 🌟 This system lets us control T cell activation using light, offering a unique way to shape T cell responses https://t.co/zpSw6neypc.
The LiTE system isn't just interesting from a scientific perspective; it also holds promise for the future of immunotherapies. We used it to generate light-activated bispecific T cell engagers that enhance T cell-mediated tumor cell killing in vitro under the control of light.
Here we describe novel light-controllable recombinant T-cell engagers that allow fine control of primary T-cell stimulation and manipulation of their response