Renal Path Labs

Renal Pathologist and Literature enthusiast!! Lifelong learner. Tweets are my own!

[Renal Path Labs @RenalPathLabs]

This FSGS was scarier than any crescent…fierce looking, activated podocytes as if ready to engulf the tuft..
And look at the tuft-scared to the core..
🥹😱
#CollapsingFsgs #RenalPath #PathTwitter #Nephtwitter #RenalPathSociety #AskRenal #RenalPathLabsGurugram #KidneyBiopsy

[Jonathan Zuckerman MD PhD @JZRenalPath]

One of my favorite incidental EM findings. Crystalline proto-renin granules in JGA cells. #renalpath #nephrology #pathtwitter

[Sanjeev Sethi @SethiRenalPath]

Difficult but good recent teaching case.

LM- normal appearing glomeruli but proximal tubules filled with eosinophilic granules.

IF- negative.

EM- large number of lysosomes, with degenerative changes.

Lysozyme stain 3+ positive in proximal tubules.

Dx: Lysozyme associated-tubulopathy (myelofibrosis/clinical).

Usually see this in patients with CML.

D/D: light chain proximal tubulopathy, but IF & pronase IF are negative.

60-yr old with chronic kidney disease, pulmonary nodules, and JAK2+ myelofibrosis.

Evaluation showed high levels of serum lysozyme, and lysozymuria.

[Renal Path Labs @RenalPathLabs]

All the hard work, is worthwhile.
Going to that extra-mile,is worthwhile.
Doing DIF on paraffin block,is worthwhile.
Considering each biopsy as precious,is worthwhile.Being a Renal Pathologist..
is worthwhile.

#Feedback #KidneyBiopsy #TransplantBx #AskRenal #Nephtwitter

[Renal Path Labs @RenalPathLabs]

Thrombi in MT are obviously pseudothrombi

[Renal Path Labs @RenalPathLabs]

Two Cryoglobulinemic GN within 10 days!
One showing microtubules on EM.
Rare are not rare in Indian subcontinent?
..

#RenalPath #Nephtwitter #PathTwitter #KidneyBiopsy #Nephpath #CryoglobulinemicGN
@AskRenal

[Jonathan Zuckerman MD PhD @JZRenalPath]

Fibrillary or amyloid? How about both! Concurrence of ALECT amyloidosis and DNAJB9+ FGN. EM shows admixed but distinct fibril population. Mass spec was required for definitive diagnosis. https://t.co/EDRfRQsLel #renalpath #nephrology #pathtwitter

[Aditya Dhar @AdityaDharFilms]

Here’s to Preetisheel, my Sardarni sister from Pathankot.
Mera Sher.😁
When I first heard her name, I’ll be honest, I was hesitant. There were all these opinions floating around, “she’s arrogant,” “she’s too expensive,” “she only does prestige projects.” And then I met her. In that one meeting, all of it just fell apart.
It reminded me of something I’ve learned the hard way in this industry, never build your truth on borrowed opinions.
More often than not, they come from a place that has nothing to do with the person you’re about to meet.
What I found in Preeti was not just an artist of extraordinary ability but a deeply warm, grounded and fiercely loving human being.
The laughter we shared in the middle of madness, the long conversations about life, the endless hours spent obsessing over every character, those are memories I will carry with me for the rest of my life. There was something about her presence, that beautiful, reassuring smile, that made even the most impossible days feel manageable.
And then there was her constant voice in my ear, lifting me up in ways I didn’t even know I needed.
“Aditya, tujhe pata nahi hai tu kya cheez hai, tujhe idea bhi nahi hai tu kya karne wala hai.”❤️
What she and her team pulled off on this film is nothing short of extraordinary. When most of the crew was waking up, they were already on set. And when everyone wrapped, they were still there. Running on barely 2–3 hours of sleep, day after day, with a kind of relentless focus that you rarely witness. No complaints. No noise. Just pure commitment to the vision.
There were more than a hundred character designs across both parts (some extremely complicated ones like Nawab Shafiq and Bade Saab).
Thousands of faces shaped, aged, transformed. An army of nearly 20,000 junior artists brought to life through detail, texture and truth.
But beyond the numbers, what stays with me is the intent.
For Preeti, it was never about “looks.” It was always about people. About making sure every character, no matter how small, felt real, lived-in and honest. She treated each face with respect, as if it had a story worth telling.
That’s rare.
Today, she’s not just my HOD. She’s family. A constant in my life, in cinema and beyond.
Preeti, thank you for standing by me, for believing in me when I couldn’t see it myself and for pouring your heart into Dhurandhar the way you did.
And this is just the beginning for us.
Love, always. ❤️

[Aditya Dhar @AdityaDharFilms]

Dearest Smriti

I still remember one of our very first conversations, when we spoke about how Jaskirat starts with a hint of colour and how, by the end, Hamza is almost swallowed by black.
How, somewhere along the way, the colour quietly leaves his life without drawing attention to it.
At that point, it was just a thought, a tiny, slightly mad detailing idea I threw at you.
And you just held on to it.
That’s when I knew 😊
Because while you kept saying “Adi Sir, I don’t know if I’m the right person for this,” I was sitting there thinking, “This is exactly why you are.”
You didn’t come with baggage. You didn’t come with a fixed ‘style’ of what this world should look like. You came with honesty and that dangerous thing called ZIDD.
And then you went and did what you do best, you over-delivered in the most ridiculous, unbelievable way.
Who stitches 10000 costumes for a film and close to 1000 Pathanis in first 30 days and still worries about the detailing of a button on a junior artist’s cuff? 😂
Who creates 250+ looks for Hamza and still loses sleep over whether the ring on his little finger feels emotionally correct?
Who manages thousands of accessories over a 1.5 year shoot and still shows up every day like it’s day one?
Only you.
The most helpful, most generous human being on set.
Always there. Always giving. Always smiling through the chaos (even when I know some days you wanted to kill most of us 😄).
What you built wasn’t just costumes.
You built a world.
A language.
An identity that breathes through every single frame of Dhurandhar.
And the most beautiful part?
From a space that once felt unfamiliar, you created something so distinct that people are now following your design styles everywhere.
That’s not talent alone. That’s courage. That’s ZIDD. 🤩
I’m just really, really grateful I got to witness that journey up close.
And I’m even more grateful that I got you on this film ❤️
Love and Luck, forever! 🙏

[Sanjeev Sethi @SethiRenalPath]

Basic evaluation of the kidney biopsy when you see an MPGN on light microscopy.

[Aditya Dhar @AdityaDharFilms]

Here’s to Shivkumar Panicker

Some relationships in filmmaking aren’t built on a single film, they’re built over years of trust, instinct, and standing by each other when it matters the most. Shiv has been that for me and much more.
He is not just my editor. He is my closest friend, my brother, my confidant, the kind of person whose loyalty is so absolute, it humbles you.
The kind of person who would stand for you, fight for you and if it ever came to it, even lay everything on the line for you.
And then there’s the genius.
Shiv is, without a doubt, one of the sharpest and smartest film editors I have ever known.
But what makes him truly exceptional is not just his craft, it’s his instinct.
His understanding of rhythm, emotion, and storytelling is almost frighteningly precise.
He doesn’t just edit a film, he breathes life into it.
With Dhurandhar, what he pulled off feels nothing short of miracle.
Yes, the decision to split the film into two parts was mine but the responsibility of making that decision work fell entirely on him. And the way he carried that on his shoulders, the way he shaped it, elevated it, and made it seamless was extraordinary.
In timelines that were, quite honestly, the craziest I have ever seen.
Where films of this scale take months, sometimes years to edit, Shiv delivered in a matter of days. Days. And not just delivered, he delivered excellence. The sharpest possible version of the film, under pressure that would break most people.
What we achieved with Dhurandhar, the scale, the quality, the deadlines is unheard of.
It breaks every conventional norm that filmmaking has followed for years. And a massive part of that credit belongs to him.
But what makes this even more special is that his contribution didn’t begin in the edit room.
He was there from the very beginning.
Like a silent co-director.
Through writing. Through prep. Through the chaos of shoot. Through post. Always present. Always thinking. Always pushing the film to be better.
He never once allowed the pressure to dilute the work.
He never once chose convenience over conviction.
He never once stepped back.
That integrity, that hunger, that loyalty is rare.
And it’s something I will carry with me for life.
The truth is, I don’t see myself making a film without him. Not now. Not ever. In many ways, he is my responsibility for life, just as much as he has made every film of mine his own.
Some contributions can be measured.
And then there are people like Shiv who become a part of your journey in a way that words can never fully capture.
Endless love, respect, and gratitude.
Dhurandhar will always carry his heartbeat within it. ❤️

[Aditya Dhar @AdityaDharFilms]

Here’s to Vikash Nowlakha, the eye, the instinct, and the soul behind Dhurandhar.
He was the last HOD to come on board Dhurandhar. Just a few days before we began. And knowing how deeply selective he is, that timing meant everything.
It felt less like onboarding a cinematographer, and more like destiny quietly stepping in at the right moment.
I still remember what he said after reading the script, “I’ve waited 30 years to do a film like this. I’ll give my life to it.”
And he meant every word.
What followed was not just work, it was devotion.
Through impossible schedules, through chaos that often felt unmanageable, through shooting what was essentially two films in the time and cost of one Vikash stood at the center of it all, steady and relentless.
Carrying the weight of the film quite literally on his shoulders, pushing through the burning heat of Amritsar and the harsh cold of Leh, he never once let the vision falter.
But what makes Vikash truly rare is not just his endurance, it’s the soul in his gaze.
His eye for detail, his emotional intelligence behind the lens, his ability to understand not just what a scene looks like, but what it feels like, that is where his genius lies. Every frame in Dhurandhar breathes because he allowed it to.
He didn’t just capture moments, he gave them life.
His inputs on set were never loud, but always precise.
Always truthful.
Always elevating the film.
There are many who shoot films.
Vikash lived this one.
And in doing so, he has given Dhurandhar something that cannot be manufactured, a soul.
I feel immense gratitude, respect, and affection for the artist he is, and the human being he brought into this journey.
This film carries his imprint forever.
And I know this is only the beginning, the stories we will tell together from here on will go even further, shine even brighter, and create something truly timeless. ❤️

[Renal Path Labs @RenalPathLabs]

Celebrating 4 years of Renal Path Labs..

#PathTwitter #KidneyBiopsy #PoojaMaheshwari #NephPath

[Dr Poornima 🇮🇳 @PoornimaNimo]

Film : Mission Kashmir : Indian police officer massacres the family of a Kashmiri, which leads to the only surviving member of the family to become a militant.

Film : My name is Khan, And I am not a terrorist.
Muslims are not terrorists, and they face intense Islamophobia in their everyday life.

Chak De India :
Indian Mslm national player is a victim of persecution & Islamophobia because he loses a match for India. Family faces ostracisation from the Hindu population of Hindu.

Mulk
Explores how a Muslim family struggles with suspicion and stigma after a terrorism accusation.

Film, Mai Hoon Naa.
Depicts Hindu Indian Army officer, Raghavan Dutta played by Sunil Shetty, sabotaging peace initiatives between India and Pakistan. While Pakistan wants peace with India.

Film Pathan
Top agent of RAW, teams up with an ISI agent to stop a dangerous terrorist group led by a rogue former Indian agent.

Shahid
Based on lawyer Shahid Azmi, focussing on wrongful accusations and defending terror suspects.

Haider
Set in Kashmir, it deals with human rights abuses, disappearances, and harsh counter insurgency actions.

Tiger Zinda Hai : Retired RAW agent rescues Pakistani Indian nurses teaming up with Pakistani ISI agent wife.

Film Firaaq
Focuses on the aftermath of the Gujarat riots and how ordinary Muslims cope with fear, persecution and loss.

Deewaar (1975
Amitabh Bachchan's character Vijay wears a porter's badge numbered 786, which famously saves him from bullets.

Coolie (1983)
Amitabh as Iqbal, wears a badge 786 which protects him from death.

Veer Zaara (2004)
Shah Rukh Khan imprisoned as pilot Veer is assigned prisoner number 786 in a Pakistani jail. He gets released with blessings.

Once Upon a Time in Mumbaai (2010) Ajay Devgan's gangster Sultan drives a car with registration MRH 786, portraying it as a sign of his invincible luck.

These movies are all based on reality. Only Dhurandhar is a Propaganda movie. 🤡🤡🤡

[Vivek Ranjan Agnihotri @vivekagnihotri]

Dhurandhar: The Revenge

I was in the countryside of California, finally made a trip to LA just to watch Dhurandhar.

Shabash. Bravo. Brilliant once again, @AdityaDharFilms. I genuinely don’t know what to say… anything I add may only become noise over something that already speaks for itself. I’d rather call you.

Everyone has done exceptional work. But I want to specifically acknowledge two less celebrated crafts that elevate this film into something far greater:

1. Vikash Nowlakha’s world-class cinematography, and

2. @sainisjohray’s exceptional production design.

In cinema, the camera and production design are married to each other. Unless both are in complete harmony, a film cannot rise to the level of a masterpiece.

In Dhurandhar, what we witness is pure synergy. Both Vikash and Saini Johray have done groundbreaking work… work that will stand as a benchmark for a long time.

My heartfelt best to both of you. And a special salute.

And Aditya, just an unsolicited word from experience: You are sharp, and you know your path. Just stay mindful of the ecosystem, it can be as vicious as it is seductive.

And everyone else in #TeamDhurandhar, you rock. ❤️❤️❤️

[Ram Gopal Varma @RGVzoomin]

Now that @AdityaDharFilms has EXPLODED a ATOMIC BOMB right under the film industry, what is shocking is the loud silence from the rest of the film industry .

I don’t know whether this is because the #Dhurandhar2 ‘s devastating explosion has hurled everyone else in the film industry so far into OUTER SPACE that their applause cannot reach here due to the long distances , OR whether they’re huddled in denial, whispering to each other , “It’s just propaganda… it will go away soon ,” so that they can crawl back and resume making their same old repetitive films.
OR are they just paralysed by the film’s sheer brilliance , realising that whatever they’ve been making or planning to make , now simply cannot measure up?
But isn’t it extremely unwise to ignore a DINOSAUR like #Dhurandhar2 staring you in the face and BREATHING FIRE into your eyes with its BOX OFFICE ROAR shaking the very ground beneath their feet , how can anyone be so foolish enough to look away?

My sincere advice to all my colleagues in the film industry is to please take #Dhurandhar2 deadly seriously and study it like a ultra fresh course in filmmaking and educate yourselves OR risk being buried forever in the graveyard of pre March 19th 2026 cinema.🙏

[Renal Path Labs @RenalPathLabs]

Trending with Trend..

बच्चा है तू मेरा..

#RenalPath #NephPath #KidneyBiopsy
#TransplantBiopsy #PoojaMaheshwari
#RenalPathology #Nephtwitter
#Dhurandhar

[Renal Path Labs @RenalPathLabs]

We dream big, but keep our feet on ground…

#RenalPathLabs
#RenalPathology
#KidneyBiopsy #OnlineLearning #Nephtwitter #OnlineRenalPathology

[Sam Albadri, M.D., M.Sc. @sam_albadri]

📌 Renal Pathology Pearl : ✅Light Chain-Only PGNMID🔦

Light chain–only PGNMID (PMID: 32001067
) shows monotypic light chain deposits (κ or λ) with absent heavy chains , a true light chain–only pattern.

💡 Key features:
• IF: Isolated light chain restriction ± C3 co-staining (reflects alternative pathway activation, not primary C3 glomerulopathy).
• LM: MPGN, endocapillary proliferative, or mesangial proliferative patterns.
• EM: Granular, electron-dense deposits (non-organized).
• Always evaluate for underlying B-cell/plasma cell clone.

📍 C3 positivity is common and due to complement activation, but not C3G — diagnosis rests on true monoclonal light chain restriction. @Renalpathsoc @MCFNephFellows @MayoClinicNeph @MayoClinicPath

[Sam Albadri, M.D., M.Sc. @sam_albadri]

🧠🩺 Renal Pathology Pearl: Lysozyme (Lysosomal) Nephropathy
📌 Often seen in CMML / monocytic leukemias
📌 Causes tubular (non-albumin) proteinuria
🔬 Light Microscopy
• Predominant tubulointerstitial injury
• Proximal tubules with eosinophilic, granular/vacuolated cytoplasm
• Interstitial inflammation ± fibrosis
• Glomeruli largely unremarkable
🧪 Immunofluorescence
• Negative for IgG, IgA, IgM
• Negative kappa/lambda
• C3 absent or nonspecific
• (If performed: strong cytoplasmic lysozyme staining in proximal tubules)
🔍 Electron Microscopy
• Proximal tubular cells packed with enlarged lysosomes
• Lysosomes contain electron-dense granular ± crystalline material
• No immune-type deposits in glomeruli or TBMs
🧩 Key clue: High UPCR + low ACR → non-albumin proteinuria
🚫 Argues against AL amyloid, LCDD, PGNMID
#RenalPath #NephPath #LysozymeNephropathy #KidneyBiopsy #MedEd @MayoClinicPath

[Renal Path Labs @RenalPathLabs]

New batch for online Renal Pathology Classes starting soon!!!

Register now!

#RenalPathLabs

#nephtwitter #RenalPathology #NephrologyResidents #PathTwitter #Nephpath