Reprotox

An information system on environmental hazards to human reproduction and development. Free for med school students, residents, and fellows in training!

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New @Reprotox website design! Head on over to http://t.co/b0D1vh9haH to check it out.

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Other studies on the use of fish oil omega-3 supplements in pregnancy did not find significant beneficial effects.

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Elevated dietary DHA or fish oil + omega-6 supplements did not significantly increase congenital defects in rats.

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Omega-6 fatty acids are more commonly consumed, and typical ratios in the US are 10 or 20 to 1.

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There are no reports on the possible reproductive toxicity from the use of omega-3 supplements during human pregnancy.

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A 2012 study reported associations between omega 6:3 ratio and infant brain development.

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A diet rich in fish (and, perhaps, the corresponding lifestyle may reduce the incidence of cardiovascular disease.

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Omega-3 fatty acids havwe a double bond at the 3rd carbon when counted back from the last methyl group.

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It is not clear the pertuzumab, which is a monoclonal antibody, would be absorbed by a nursing infant.

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Pertuzumab is not recommended during pregnancy based on its prominant fetal toxicity in monkeys.

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Pertuzumab is not recommended for nursing women according to the product labeling, in spite of a lack of data.

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Pertuzumab also caused oligohydramnios and fetal renal lesions in monkeys.

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Pertuzumab is marked for the treatment of breast cancer in combination with trastuzumab and docetaxel.

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Pertuzumab given intravenously to pregnant cynomolgus monkeys every 3-4 days, caused abortion and decreased fetal weight

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This monoclonal antibody that antagonizes the HER2/neu receptor by preventing its dimerization with other receptors.

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We just added pertuzuman (Perjeta) to Reprotox.

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Fish oils (#2249) contain the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

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Demeton is an organophosphate pesticide marketed as Systox.

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Demeton toxicity in avian embryos is due to abnormal muscle function associated with cholinesterase inhibition.

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Chick embryos showed wry neck and other muscular problemsand had cardiac malformations and thoracogastroschisis.