mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism
Wait, doesn't mTORC1 (or just mTOR) promote anabolism, necessary for muscle growth?
Yes, but chronic activation drives muscle loss.
This is something that many people, both in life extension and in fitness circles, get wrong.
Cyclical, or on and off, activation of mTOR is what you want.
Like a sine wave
To activate mTOR and promote muscle growth: do resistance training, eat protein.
To deactivate mTOR and promote autophagy: fasting, caloric restriction, carb restriction, exercise, heat stress (sauna), cold exposure (cold water), dietary polyphenols (main sources: coffee, tea, red wine, chocolate).
Chronic activation is seen in obesity and insulin resistance, because insulin activate mTOR.
Muscle loss here is evidence for the late @Blagosklonny 's theory that chronic mTOR activation is the main driver of aging.
https://t.co/RFMClf3pcw
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head(), shape, dtypes, describe()
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Extract relevant rows and columns with ease.
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Use loc[] (labels) and iloc[] (positions).
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isnull(), dropna(), fillna()
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Summarize data using groupby() and aggregation functions.
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Combine datasets with merge() using different join types.
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