Schmidt Science Fellow in the Chandel Laboratory at Northwestern University studying the intersection of mitochondrial dysfunction and neuroinflammation
Excited to report that our new paper is out now:
https://t.co/ZhNB4Im8Av
A thread:
We asked how the brain represents odor pleasantness. Are pleasant and unpleasant odors represented on the same neural axis? Our results suggest: not at first, and not as one would assume.
The translational potential of #metformin in #HuntingtonsDisease is compelling: https://t.co/NqME8cH7Nq
Robert M. Friedlander & team report metformin regulates mitochondrial fission, reprograms deregulated metabolism in HD microglia, and controls microglial activation and inflammation in HD transgenic mice.
The image shows traced microglial morphology from striatum of the HD mouse model R6/2 treated with metformin.
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR.
We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets.
Thread + link below.
This @NYTmag article on longevity science, reversing aging with cellular reprogramming, by @susandominus, is over the top. We have no proof that rejuvenation of a human organ is possible, no less the whole body, and there is risk of inducing cancer.
gift link https://t.co/VEGpaBncFN
@biorxivpreprint Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleen
https://t.co/JWJbF6r2fE @Misharin_lab @NorthwesternU
If FDA does this, which is highly likely succumbing to pressure from RFK Jr, it crosses a new red line and, as far as I know, is unprecedented. Lifting a ban on drugs that are injected into the bloodstream without data for safety or efficacy, so they can be compounded and further promoted to Americans.
@By_CJewett
Gift link
https://t.co/Y1xytcpqDD