Roselli lab Uni-Ulm

Neuro-people doing cellular/circuit/synaptic/translational research on ALS and acute brain injuries using viruses, microscopes, immunology and biochemistry.

[Roselli lab Uni-Ulm @RoselliLab]

@jdpereira how expensive is it? DM me and let´s talk.

[izabela_horvath @IzabelaHorvath]

Very happy to share that the culmination of my PhD work is out in @Nature! With MouseMapper, we can segment organs&tissues across whole mouse bodies and map changes in targets(nerves, immune markers) to the obtained atlas! Hope this will be a useful tool for preclinical research!

[Roselli lab Uni-Ulm @RoselliLab]

congratulations!!!!!!

[Weidinger Lab @WeidingerLab]

Great news! CRC1506 “Aging at Interfaces” has been renewed. This is exciting for Ulm University and our group. We are happy to continue studying how zebrafish regenerate through enhanced anti-aging mechanisms. Thanks to Hartmut Geiger and his team for their outstanding work!

[Martin Heni @MaHeUlm]

What does glucagon do in the human brain after a meal?

Using OGTT + fMRI + glucagon infusion, we found altered responsivity in hypothalamus and reward-related brain regions.

Interesting biology behind glucagon co-agonism.

https://t.co/8C2fhZfl5A
@wagrob
@Steph_Kullmann

[Roselli lab Uni-Ulm @RoselliLab]

Hi everyone. We are available to accept applications from students willing to submit a CSC proposal for a lipidomic/metabolomic study. Background in neurodegeneration/neurology/neurobiochemistry necessary. Please contact through institutional email.

[Roselli lab Uni-Ulm @RoselliLab]

great visit to the Mario Negri Institute, to the formidable Elisa Zanier and the Dept. of acute brain and cardiovascular injury!

[Roselli lab Uni-Ulm @RoselliLab]

Looking forward to talk at the Mario Negri Institute tomorrow. We present new unpublished work on our forays into large-animal-models of brain injury!

[gen0m1cs @gen0m1cs]

Happy DNA Day.

[Journal of Clinical Investigation @jclinicalinvest]

Implications for protecting against cognitive impairment following #HeadInjury👇
https://t.co/cODGSIjCSR

Here, Tao Li @taoli Michael T. Heneka @michael_heneka Sergio Castro-Gomez @CastroGomezSerg & team find the inflammasome adaptor ASC drives long-lasting brain inflammation and cognitive problems after mild head injury in a closed-head injury model.

The figure shows skeletonized activated microglia (Iba1+ cells) following closed head injury, with mice lacking ASC show showing preservation of morphological features, particularly at later time points.

[Roselli lab Uni-Ulm @RoselliLab]

what about inhibition in ALS motoneurons? is it really decreased, and why? what happens if one decreases it even further? do MN really die faster, or not? find it out in our latest JNeurosci paper: https://t.co/aTPTACEzJJ

[Roselli lab Uni-Ulm @RoselliLab]

How and when are synapses lost in TBI patients? We used two new markers of synapses in CSF and wefound two waves of synaptic loss in TBI, one of which inflammation-dependent: https://t.co/sVhApDtajC

[The Brain Prize @BrainPrize]

The review article on the 2026 Brain Prize winners' science is out: The cellular architecture of touch and pain, by Professor Fan Wang (MIT, US)

[Roselli lab Uni-Ulm @RoselliLab]

time to revisit excitation/inhibition balance in motoneuron disease: what have we actually learned? have a look: https://t.co/Oo0ZBGgOHs

[Roselli lab Uni-Ulm @RoselliLab]

What happens when brain people meet bone people? A study of bones in neurodegenerative disease: https://t.co/qycPmCqpe8

[Roselli lab Uni-Ulm @RoselliLab]

what connects intracranial hypertension to neuroinflammation? in astrocytes the mechanosensor Piezo cross-activates EGFR, which in drives chemokine secretion and reduces water fluxes. from porcine model to human cells: latest preprintis out: https://t.co/nNQIZYLb5H

[Roselli lab Uni-Ulm @RoselliLab]

What happens to lipid metabolism in ALS? What connects hypothalamus to the movement of triglycerides across the body? Angiopoietins coordinate the repartitioning of lipids from muscles to brown adipose tissue when hypothalamus is neuro-inflamed : https://t.co/jJDZwZT2bE

[Roselli lab Uni-Ulm @RoselliLab]

In the acute phase of traumatic brain injury, how does the body keep in check the inflammatory response? It appear that basophils are recruited to the spleen follicles to deliver much-needed IL-13 to dendritic cells : https://t.co/6kfS4cCwjH

[Roselli lab Uni-Ulm @RoselliLab]

What happens if you remove inhibitory synapses from a motoneuron? does it die faster or slower? here our chemogenetic-nanobody in vivo study: https://t.co/RX6rX0m66h

[Roselli lab Uni-Ulm @RoselliLab]

What happens to hypothalamus in neurodegenerative diseases? It appears that its involvement is more common that previously thought. Our latest collaboration with the great group of Jan Kassubek: https://t.co/x0TQU5mMdl