Ryan Chadek

Web Developer, Musician, Husband, Father, Beer Lover

[Mom @mom_agency_]

Claude's first day at Dunder Mifflin

[JER @lifeof_jer]

https://t.co/ofucbVgkLV

[Nick Norwitz MD PhD @nicknorwitz]

Peter Misses the Plot: a Swift Debunking 👇

It’s come to my attention that @PeterAttiaMD has come out with an attempted debunk to The Cholesterol Code documentary and, more broadly, the research on lean mass hyper-responders.

I won’t mince words: It’s embarrassing. It’s simultaneously arrogant, deeply misinformed, and, as I read it, a transparent avoidance of the facts at hand. It’s posturing, not insight. And I’m prepared to back that up.

First, Peter attempts to discredit the documentary, the research on lean mass hyper-responders, and the Lipid Energy Model, on superficial grounds: credentials and authority.

He almost exclusively referring to the work as a product of the Citizen Science Foundation (CSF), i.e., @realDaveFeldman: the 'uncredentialed' outsider.

He conspicuously avoids discussing the broader teams involved, many of whom carry credentials that would easily meet the standards typically valued in more traditional, credential-focused settings (and exceed his own). Even setting aside myself, an MD-PhD, there is: Dr. Adrian Soto-Mota, MD-PhD, ith the Lundquist team, there are others who have co-authored work in this space, including Anatol Kontush, Ronald Krauss, William Cromwell, and, notably, Peter’s own former head of research, Bob Kaplan. Go figure.

Might have been a fact fact for Peter to include: "My former head of research was a coauthor on the Lipid Energy Model paper I'm inadequately trying to debunk."

And that’s the short list.

I’ll also point out that when I was writing an editorial on lean mass hyper-responders, I reached out to Peter, and he declined to contribute, citing that it was not his area of expertise.

He instead referred me to Ronald Krauss at “the expert,” who has now collaborated with us on a couple of projects.

So even at a superficial level, what we’re seeing here is avoidance, posturing, and frank hypocrisy.

Peter further attempts to cast doubt on lean mass hyper-responders by questioning the existence of the phenotype, which is, frankly, comical. It exists. It is defined by three clear cut points, and people meeting those criteria unquestionably exist. It is also a dynamic and reproducible phenomenon, as demonstrated by multiple experiments, case series, and even meta-analyses of randomized controlled trials that we have published. Peter forgot to talk about those data. No surprise there.

Peter also demonstrates a misunderstanding of the Lipid Energy Model, for example by incorrectly suggesting a contradiction between the model and the low triglycerides observed in lean mass hyper-responders. And, more broadly, he reveals a lack of familiarity with the practical realities and constraints of clinical study design. If we are going to lean on authority, then it is fair to ask about experience. To my knowledge, Peter has not conducted clinical trials, and frankly, that gap shows here.

At a deeper level, I don’t think Peter understands this physiology or this domain. And behavior like this, particularly when presented under the banner of scientific critique, is exactly the kind of thing that fuels “broader distrust in institutions and experts.”

This is a textbook case of the pot calling the kettle black.

I could go on, but I think the core point is clear. If further discourse is needed, Peter and his colleagues, including Tom Dayspring, have had ample opportunity to engage, collaborate, and discuss these ideas directly.

If they choose not to, that speaks for itself.

In the meantime, we’re not going anywhere. And no amount of pedantic posturing is going to change the trajectory of the data.

Oh, and two more things…

i. For those tempted to fall back on the overly simplistic take that “they’re saying high LDL is good” and “fear mongering about pharma,” or similar caricatures, you’ve entirely missed the plot.

And, I have something coming this week.

Again, if you interpret it as a pivot, you’ve missed the point entirely, as Peter has.

ii. Finally, Peter’s central criticism seems to be that the documentary and our research suggest that even very high LDL cholesterol may not always indicate cardiovascular risk.

Well, yes.

The alternative is to argue that in all circumstances, at all times, very high LDL necessarily drives cardiovascular disease.

This isn’t about discrediting, with a blanket statement, any role of ApoB or LDL in cardiovascular disease. This is about asking important questions at the frontier of science, because the status quo has been wholly inadequate in addressing the problem at hand.

That's obvious.

At least to some extent, we have been barking up the wrong tree.

Anyone with a modicum of perspective can see that.

And anyone with genuine curiosity would be willing to engage with the nuance, rather than lecture, avoid, and misrepresent, as Peter is doing here.

Lastly: See the Cholesterol Code Documentary. It's on Amazon. And judge for yourself.

[Darrell Root @DarrellRoot]

@Osinttechnical Predicted by Gary Larson:

[Ryan Chadek @RyanChadek]

My 2025 Duolingo stats are in! How did you do? #Duolingo365

[Ryan Chadek @RyanChadek]

My recap from #WordCampUS 2025 is now live!

Read "Beer and Coding in Portland" https://t.co/cWO1t1Yo1B

#OpenSource #WebDev #Inventive

[Inventive Group @InventiveGroup]

Open source isn’t built in boardrooms — it’s built in rooms full of coffee, code, and debate. ☕💻

@ryanchadek’s recap from WordCamp US 2025 in Portland captures it all:

👉 https://t.co/G1TxpDgBJ6

#WordPress #OpenSource #Inventive #Community

[Forbes Technology Council @ForbesTechCncl]

From 'If This, Then That' To AI That Thinks Back https://t.co/gX8VH5BuwX Written by @asiemer of @inventivegroup

[Ryan Chadek @RyanChadek]

WordCamp 2025 Showcase Day is in the books. So many creative and inspiring ways contributors continue to push the boundaries of what's possible with WordPress! #wcus

[Alex Berenson @AlexBerenson]

Here’s how the New Yorker refers to the Daniel Penny case:

No matter how much you think they lie, you’re wrong. It’s worse.

[Advanced Custom Fields @wp_acf]

The ACF team has been blocked from accessing WordPress dot org and are unable to release updates for the free version of ACF.

We have a solution to ensure users receive updates going forward.

Learn how to manually update to the latest version of ACF:

https://t.co/c74bgiAlE6

[Ryan Chadek @RyanChadek]

I just donated to 2024 E-Solicit September! Help support San Antonio Food Bank today! https://t.co/rrkUR7HcUa

[Alex Berenson @AlexBerenson]

https://t.co/GbCtZRqik5

[James Clear @JamesClear]

Surround yourself with people who have the same goals as you. Rise together.

[Dave Feldman @realDaveFeldman]

🚨🚨🚨🚨🚨🚨🚨🚨
BREAKING: FIRST PUBLICATION NOW AVAILABLE —> https://t.co/AJzp1wuoM4

KETO-CTA (#LMHRstudy) vs Control (#MiHeart)
-🙏Please Share! 🙏-

METHODS – 80 Participants of #LMHRstudy fell within #MiHeart age range and were then matched 1:1 for age, gender, race, diabetes mellitus, hyperlipidemia, hypertension, and past smoking to asymptomatic subjects from the #MiHeart cohort.

PRIMARY ANALYSIS – High resolution heart scans (#CCTA) allowing for primary analysis of Total Plaque Score (TPS), Total Stenosis Score (TSS) and Segment Involvement Score (SIS)

RESULTS
The matched mean age was 55.5 years, with mean #LDL cholesterol of 272 mg/dL (max LDL-C 591) mg/dl and mean 4.7 years duration on a ketogenic diet.

🚨 There was no significant difference in coronary plaque burden of #LMHRstudy (mean LDL-C 272) cohort as compared to #MiHeart controls (mean LDL 123 mg/dl); nb: pre-KETO LDL-C in KETO group was 122 mg/dl

🚨 There was no significant difference in CAC (median and IQR) [0 (0,56)] versus [1 (0, 49)], p = 0.520

🚨 No relationship of LDL-C elevations and plaque

⚠️ NOTE: This analysis is on baseline scans, we will have further data on the Keto-CTA longitudinal analysis in the coming months. And — as always — please continue to work with your doctor.

🙏🙏🙏 Special thanks to everyone who got us to this first publication milestone. 🙏🙏🙏

Extra shout out to @nicknorwitz @DrRagnar @AdrianSotoMota @khurramn1 and, ofc, @BudoffMd

And a MASSIVE thanks to everyone who has contributed their money, time, and/or sharing to help us spread the word and make this research a reality!

(PS — this is unfortunately not Open Access as this wasn’t an option we had available for us — but the full manuscript will be published soon as a separate paper and *will* be open access)

[Alex Berenson @AlexBerenson]

https://t.co/FXLJrOAj9K

[Alex Berenson @AlexBerenson]

New Unreported Truths, about the never-ending insanity of Team Apocalypse

[Ryan Chadek @RyanChadek]

Proud to be the 800th 😎 on @BackerKit for Web Awesome. Thanks @fontawesome https://t.co/lo4qGuNItq

[LastPass @LastPass]

An active phishing campaign is targeting LastPass customers.

Be suspicious of, and ignore unsolicited incoming calls and texts claiming to be from LastPass. More on the scam: https://t.co/MsEVYPmWUT.

Ways to help protect yourself from #phishing: https://t.co/1KiPnaxUJl.

[Ryan Chadek @RyanChadek]

I just backed Web Awesome on @Kickstarter https://t.co/X8W3TsLjFl

[Alex Berenson @AlexBerenson]

More VERY bad news coming for all those who pushed the mRNAs on young children