@ProfTomEllis 1) A full bacterial D-proteome is unlikely to contain these sequences at cleavable positions, 2) they didn't test cleavage of proteins, just peptides. Overall it seems consistent with existing literature suggesting that D-proteins are broadly resistant to degradation
@ProfTomEllis Using a combinatorial search, the authors were able to find a couple of specific D-amino acid sequences which could be cleaved by some of the promiscuous proteases tested. This finding doesn’t tell us that much about the immune response to a full mirror bacterium:
@Nfcanavan@GruppSteve@nytimes Hi Neil, immunologist and fan of The Cure Within here. A few reactive T cells could be generated, but the overall T cell response would be weakened by 1) poor mirror antigen presentation due to resistance to proteases, and 2) weak inflammation due to innate immune evasion
New @CGDev policy paper:
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@Hal_RTFLC@JustinSandefur Close, it will prevent more cases than *vaccinations* (4 doses/vaccination). The $7/case prevented was at an assumed price of $3, but the current supply agreement is at $3.90 so this model estimates ~$10/case prevented.