Ryan Duncombe

[Ryan Duncombe @RyanDuncombe]

@ProfTomEllis 1) A full bacterial D-proteome is unlikely to contain these sequences at cleavable positions, 2) they didn't test cleavage of proteins, just peptides. Overall it seems consistent with existing literature suggesting that D-proteins are broadly resistant to degradation

[Ryan Duncombe @RyanDuncombe]

@ProfTomEllis Using a combinatorial search, the authors were able to find a couple of specific D-amino acid sequences which could be cleaved by some of the promiscuous proteases tested. This finding doesn’t tell us that much about the immune response to a full mirror bacterium:

[Ryan Duncombe @RyanDuncombe]

@Nfcanavan @GruppSteve @nytimes Hi Neil, immunologist and fan of The Cure Within here. A few reactive T cells could be generated, but the overall T cell response would be weakened by 1) poor mirror antigen presentation due to resistance to proteases, and 2) weak inflammation due to innate immune evasion

[Justin Sandefur @JustinSandefur]

New @CGDev policy paper:

*MALARIA VACCINES* are a huge scientific breakthrough. But the world is dragging its feet on rolling them out.

We examine why, and how to go faster.

🧵

[Ryan Duncombe @RyanDuncombe]

@Hal_RTFLC @JustinSandefur Close, it will prevent more cases than *vaccinations* (4 doses/vaccination). The $7/case prevented was at an assumed price of $3, but the current supply agreement is at $3.90 so this model estimates ~$10/case prevented.