Sam Savson

You should be learning something new every day || Neuropsychopharmacology since 2013 || Mitochondrial Supremacist

Nothing I say is medical advice

[Sam Savson @SSavson]

@MeesesRfriends Postbiotics are cool, but akkermansia is not a histamine producer

[Sam Savson @SSavson]

Why

[Sam Savson @SSavson]

@t0lstoiy Very much in line with what I have seen

[Sam Savson @SSavson]

Pyridoxine B6 toxicity is likely overblown, but only in the sense of cofactor deficiency, individual genetic processing variations, and mislabeled/overdosed supplementation

Large majority of people can use reasonable doses of it with no issues

[Sam Savson @SSavson]

@t0lstoiy Sounds about right

What cofactors made the biggest impact for you?

[Sam Savson @SSavson]

Dose of the former is likely too much to be taking long term, 15mg is more reasonable as a daily

I also suspect that there is variation between supplements and some not only have less or MORE than they say they do, but may even contain a different form than what is listed

There was a lawsuit a while back about severely overdosed B6 supplements

[Sam Savson @SSavson]

@TakeThiamine We have to create good ones

[Sam Savson @SSavson]

@FarvingCo Big fan of this dirt bacteria

[Sam Savson @SSavson]

3 grams most days

[Sam Savson @SSavson]

Ive taken at least a gram of taurine daily for two years with no breaks

Gonna see what happens without it

I suspect it will be minimal, but less inhibitory tone should be interesting, even if mild

[Sam Savson @SSavson]

Sodium butyrate powder has gotten to the point it feels like im dry scooping confectionary sugar powder

It still smells as cheesy as it always has, but it's like my body knows it's good and has created a positive taste

[Sam Savson @SSavson]

My step count is directly correlated with how much carbs I'm eating

[Sam Savson @SSavson]

@saturnmissiles @RVG_sieve @timemagnet I generally only take 5-10mg at a time, will titrate if more required

[Sam Savson @SSavson]

@PGC1a_RB This is a very potent probiotic product

[Sam Savson @SSavson]

Oh no I ran out of gingko oh wait nvm

[Sam Savson @SSavson]

@brasilenjoyer Haha almost, yeah

[Sam Savson @SSavson]

@RVG_sieve @timemagnet Actually looks pretty good other than the B6 dose pushing into excessive territory, if they wouldnt have gone above 15mg it could have been perfect

[Sam Savson @SSavson]

D Lactate buildup has a very distinct feeling

Not good

[Sam Savson @SSavson]

Other theories- Thiamine HCl is bound to HCl, could be increasing stomach acid mildly, perhaps unlikely

Riboflavin requires a lot of water to dissolve properly

B6 used in cofactor for serotonin synthesis, could be pushing 5ht3 (nausea receptor) too hard

Folate as mentioned could just be intense/similar in 5HT3 sense although less likely, or other methylation related pathways

More likely is perhaps chemical irritation because of the massive amount of compounds unbuffered dissolving in stomach, perhaps a larger volume of liquid would help, or predisolving in water (Cant really see anyone wanting to do that though)

[Sam Savson @SSavson]

Started using methylfolate again after not really supplementing much folate, and honestly not even hitting the DV many days, and wow, even 100mcg of methylfolate in the AM is very, very noticable

Empty stomach, it almost feels like a stimulant kicking in, can feel it in my blood

[Sam Savson @SSavson]

@paige_eden That's very interesting and I've never heard that before

Is it immediate or consistent across different B Complexes? Wonder if its physical in the sense that zinc can do something similar, but its more of a direct mechanical irritation with zinc

[Sam Savson @SSavson]

@simpleorganix I have cameras set up and agents with hidden cameras for this exact purpose

[Sam Savson @SSavson]

Crenulata and I go way back, first used it in 2019

My first instinct was to just chew and swallow the cut/sifted root pieces and have done that ever since

Never really compared to R. Rosea, but I have not experimented with the whole root in the same way I have with crenulata

Crenulata extracts are absolutely nothing like the whole root, have never found them to be as good

[Sam Savson @SSavson]

Rhodiola Crenulata

An excellent anti-hypox/mitochondrial herb