RoanS77

He/Ro/She/Ma 👀
Just the average Penguin...
jk, one of the three Vicars of the Sacro Polaretto

[RoanS77 @SacroPolaretto]

@MrBeast 104207

[Mineplex @Mineplex]

Mineplex returns June 12.

[silentwosperer👻🎃 @silentwisperer_]

MINECRAFT JAVA EDITION IS FINALLY GETTING EASY MULTIPLAYER SUPPORT!! And a friends list!!

Easy access to play with your friends is easily the biggest thing that bedrock edition does better than java!

[DiscussingFilm @DiscussingFilm]

Eric Kripke says Donald Trump posting a photo of himself as Jesus ruined the Homelander as God joke in ‘THE BOYS’.

“A month ago when we were talking about marketing, I was like, Homelander saying he’s God is so out there. We have to be careful about how we even introduce the idea to the public because they’ll say he’s gone too far and here we are. It’s just really hard to out-satire this world.”

(Source: https://t.co/qmq48tStfA)

[RoanS77 @SacroPolaretto]

@kingpminch Giratina Origin 👀

[Marvel Rivals Intel @RivalsAssembled]

New One-Shot Combo for Deadpool and Jeff

Via/emicooterou

[Aakash Gupta @aakashgupta]

This isn’t a random scientist who got lucky.

Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.

KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.

The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.

Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.

The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.

Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.

[Riot Games @riotgames]

Congrats on early access 👊

[Hytale @Hytale]

Hytale Early Access
AVAILABLE NOW! #Hytale

[Riot Games @riotgames]

After evaluating multiple offers, we’ve reached an agreement to return Hytale to @simon_hypixel, giving this community its best shot at experiencing a revised version of the game. Wishing the team the best of luck for what’s ahead.

[Hytale @Hytale]

In today’s exciting new blog post, Dan and Amber dive deep into the future of Hytale’s world generation!
Discover the incredible new features, capabilities, and potential for both our players and creators. Screenshots, videos and more!
https://t.co/CzUCEpeHB1

[RoanS77 @SacroPolaretto]

@OsiriaRaven @BlueGoesFast

[Supergiant Games @SupergiantGames]

We’re deeply honored that HADES II is in the running for Game of the Year and more at #TheGameAwards tonight, especially since we’re in the company of such an amazing group of wildly different and beautiful games.

Congratulations to all our fellow nominees — we salute you!! 🙏👏

[RoanS77 @SacroPolaretto]

@Simon_Hypixel Bingo 👀

[Hytale @Hytale]

Hytale Early Access
JANUARY 13, 2026

[Chronozbergh☕ @Starbind_S]

Green Prince.
#HollowKnightSilksong

[Løri @haylsho]

He has such a way with words

[Hytale @Hytale]

Hytale is saved.
New Blog Post LIVE -> https://t.co/N7oc2Mw8Yv

[Simon @Simon_Hypixel]

We did it. Hytale is saved. We have acquired Hytale from Riot Games.