Sam Davis

Building CoFormBio | Ex-EQRx (exit), Ex-Scipher, Ex-Goodwin | China expert | ☘️ Celtics | 我叫王明 杰 | سام

[Sam Davis @SamDavisBio]

@PhilipJohnston

[Sam Davis @SamDavisBio]

@DaveARicks @WassimLaroussi3 Cc @jrkelly re automation

[Sam Davis @SamDavisBio]

@AAMortazavi Wow!

[Sam Davis @SamDavisBio]

Exactly. Synergistic ≠ orthogonal.

[Professor Oak @Prof_Oak_]

Great exemplar for the ideal mAb co-formulation use case: (i) orthogonal, clearly additive biological axes; (ii) much harder for a bsAb to consistently saturate individual pharmacology of one soluble & one membrane-bound target simultaneously $ABBV $SYRE

[Sam Davis @SamDavisBio]

a4b7 biosim (vedolizumab) is already out, Sandoz is developing a Skyrizi Il23 biosim (LOE 2033), so that's 2/3 of its combo strategy... where is the IP moat?
SPY120: Co-formulation combination of SPY001 (anti-α4β7) + SPY002 (anti-TL1A) in Phase 2 SKYLINE trial for UC.
SPY130: Co-formulation combination of SPY001 (anti-α4β7) + SPY003 (anti-IL-23) in Phase 2 SKYLINE trial for UC.
SPY230: Co-formulation combination of SPY002 (anti-TL1A) + SPY003 (anti-IL-23) in Phase 2 SKYLINE trial for UC and immune-mediated diseases.

[Sam Davis @SamDavisBio]

@pmarca Rumination is the bastard child of introspection - agree 100%

[Sam Davis @SamDavisBio]

This! Co-formulation is the way (don't believe us - see $ABBV CEO note, see $JNJ see $SYRE. CoFormBio is first AI/SI immunology company focused on solving the efficacy cliff with rapid development combination therapies of validated targets with novel co-formulation IP, powered by our AI/SI engine, CoFormForge. It is not an afterthought/pivot or pipeline rescue strategy for us. It is our strategy. If you are a believer - drop a dm.

[FierceBiotech @FierceBiotech]

AbbVie may have found a way to improve on its blockbuster Skyrizi. https://t.co/ZBBofFXw6e $ABBV

[Sam Davis @SamDavisBio]

@RecursiveChris @mkoeris @Tesla 🎯 again I don’t love the tech/auto analogue BUT their respective “halo” or moonshot tech products showcasing the bleeding edge of innovation, often trickles down to, and benefits consumer accessible products…

[Sam Davis @SamDavisBio]

@drrichjlaw @RecursiveChris @Tesla This☝🏼

[Sam Davis @SamDavisBio]

@nabihasaklayen Your latest branding (campaign) however, is chef’s kiss.

[Sam Davis @SamDavisBio]

@nlarusstone It’s intentional - thousands of (non bench lab) careers depend on slow, manual, human processes.

[Sam Davis @SamDavisBio]

@Jack_O_Meara @echo_nyc

[Sam Davis @SamDavisBio]

@MattyKirsh

[Sam Davis @SamDavisBio]

*i am aware that George Church is attempting to bring to life Jurassic Park, however

[Sam Davis @SamDavisBio]

Biotech: “we are pleased to announce an oversubscribed Series A financing for our 🇨🇳 licensed preclinical TCE”

Tech:

[Sam Davis @SamDavisBio]

Founders and builders - come bring your game #LATechWeek today at 3.

[Sam Davis @SamDavisBio]

@nabihasaklayen @vkhosla Brilliant

[Sam Davis @SamDavisBio]

@patricksmalone This is being done Columbia I can intro you