Sam Resnick

Columbia MD/PhD Student

[Phase Transition Papers @Pha_Tran_Papers]

A multiplex platform to identify mechanisms and modulators of proteotoxicity in neurodegeneration https://t.co/FNwq6NLNkW

[Sam Resnick @SamResnick]

-We also did some deep mutational scanning on DNAJB6 and identified variants with enhanced activity!
-Really couldn't have done this without our collaborators! This project has been on my mind daily for many many years and I'm very pleased to be able to share it

[Sam Resnick @SamResnick]

My second paper from grad school! We worked with Peter St George-Hyslop, Gabriele Kaminski Schierle (@mng_ceb), and the @RuggeriLab
A multiplex platform to identify mechanisms and modulators of proteotoxicity in neurodegeneration https://t.co/rKgAxBBduF

[Sam Resnick @SamResnick]

-We identified DNAJB6 as a chaperone with activity against multiple ALS/FTD associated models including TDP-43, FUS, and hnRNPA1 in both yeast and mammalian cell culture
-We showed with multiple in vitro techniques that DNAJB6 modulates FUS's propensity to aggregate

[Sam Resnick @SamResnick]

If your lab has 293T cells, crystal violet, and a plate reader, you can do this assay! It's reporter-free, transfection-based, and robust to protocol variation. We hope this assay will expedite therapeutic identification and will be highly useful in the case of future pandemics

[Sam Resnick @SamResnick]

My first publication from grad school! In collaboration with the David Ho and Brent Stockwell labs, we developed a simple cell culture-based assay to identify protease inhibitors targeted at SARS-CoV-2 and other coronaviruses #COVID19 https://t.co/JvPfOTcttQ

[Sam Resnick @SamResnick]

The assay we developed works well for numerous coronavirus proteases and many known protease inhibitors. We get potency data highly similar to data produced from live virus assays. We can identify compounds that are broadly active against strains with the ability to infect humans

[Sam Sternberg @shsternberg]

Our newest manuscript is live on bioRxiv! Beautiful work led by Leo @Vopinator in the lab, for high-efficiency, multiplexed DNA insertions in bacteria using CRISPR RNA-guided integrases. A great collaboration w/ @RondaCarlotta and @harriswangnyc. 1/n

https://t.co/be90twd2Rw

[Businessweek @BW]

⚡️The world's most famous AIDS researcher is racing to find a coronavirus cure
https://t.co/5b0sjBBu7i

[Sam Resnick @SamResnick]

A First-of-its-Kind Library of Potential Coronavirus Drugs | Time https://t.co/VX6I7MS6V6

[Sam Resnick @SamResnick]

@jesseraab Go big or go home!!

[Sam Resnick @SamResnick]

@jesseraab Congrats Jesse!!!!

[Sam Resnick @SamResnick]

@UgaChromatinLab I like this one: https://t.co/6LBXN0cMws

[Sam Resnick @SamResnick]

@NYCTSubway Physically yes but mentally no

[Sam Resnick @SamResnick]

@NYCTSubway I just spent an hour and 7 minutes on an A train stopped between 23rd and 14th street wtf