Sarah Ng

[Michael Hofman @DrMHofman]

Stunning research from @EdmondMKwan on ctDNA in theranostics:
🧬Low ctDNA predicts better response with ¹⁷⁷Lu-PSMA-617 vs. cabazitaxel chemotherapy
⚠️PTEN alterations linked to worse outcomes on cabazitaxel
🧪ATM defects tied to favorable PSMA-617 results
🩻PET quantitative biomarkers (SUVmean) are additive

🌟We identify new candidate biomarkers for ¹⁷⁷Lu–PSMA-617 selection and ultimately expand the mCRPC predictive biomarker repertoire

Online at @NatureMedicine
https://t.co/WvEQS4ZWol

@ANZUPtrials #TheraP @MovemberAUS @PCFA
Support by @PCF_Science Challenge Award
@ResearchWyatt @AzadOncology @Prof_IanD

[Edmond Kwan @EdmondMKwan]

On the eve of #ASCO25, I am delighted to share results from the correlative analyses of the @ANZUPtrials phase II TheraP study, now published in @NatureMedicine. Massive effort supported by dedicated co-investigators, coordinators, patients & families from 11 study sites across Australia 🙏🏼 🧵1/10

https://t.co/86fjyozQ2Q

[Sarah Ng @sarahwng]

So proud of @cherberts1 and team. Very fortunate to be mentored by and work alongside such deep-thinking and dedicated scientists.

[Alex Wyatt @ResearchWyatt]

Here’s our @Nature paper on v deep whole-genome sequencing of serial ctDNA and met tissue. @cherberts1, Matti, Joonatan et al applied new methods to give fascinating insight into temporal #ProstateCancer clonal complexity and evolution of resistance. 1/7 https://t.co/xTqXwj83JP

[Alex Wyatt @ResearchWyatt]

Grateful to receive CIHR funds for work with co-leads @piet_ost, Kim Chi on the genomics of de novo metastatic PCa prior to treatment. It’s a potentially lethal disease state about which we have strikingly little data; h/t @sarahwng for this visualization of the challenge

[Alex Wyatt @ResearchWyatt]

Too many papers focus on the promise of liquid biopsy without recognizing the limitations. Here’s @cherberts1 and my take on how ctDNA fraction (tumor purity) and assay design combine to constrain what types of genomic alteration can be detected in ctDNA. https://t.co/mnhEZxFJDt

[Alex Wyatt @ResearchWyatt]

Congrats to compsci students @EmiliaCXY and @sarahwng for winning best basic science prize at our dept research day last week, officiated by @Chris_Barbieri1! Their work is all the more impressive as they are undergrads who have never benefitted from normal research immersion 👏

[David M. Berman @virchow]

I am wearing #PlaidforDad in honor of my stylish and wise dad Monty, who died of #prostatecancer in 2015. He inspires my #prostatecancer research which is made possible by @ProstateCancerC . Please give generously. Retweets earn an extra $5 donation by Janssen.

[Andrew Murtha @MurthaAj]

The @ResearchWyatt lab repping plaid this Father's Day weekend at the @VanProstateCtr #PlaidforDad