What gets erased when you integrate single cell data, and can you recover it? Finally, we know what happens and how to recover the lost signals. So excited to share CellANOVA, published online today in NBT! https://t.co/IBYxBXt2PX
How much of our genome is 'noise' and how much is actually functional? In the de Boer lab's latest paper (along with @DarkMatterDNA) we aim to uncover the truth behind this long standing debate! 1/ https://t.co/68Pyt7JAPK https://t.co/Iis47rVz9Y
How do we uncover cell-cell interactions from #SpatialTranscriptomics data? Excited to share Niche-DE (https://t.co/0LSSqYgodz). Niche-DE asks how does a cell’s transcriptome depend on its spatial neighbors, by identifying Niche-Differentially Expressed genes. 1/9
What gets erased when you integrate #singlecell data across samples/studies, and can you get it back? When samples are from e.g. healthy & disease, should you simply massage cells together? FINALLY, I feel we can answer this question: https://t.co/0PrkIZDyDp
New preprint from our group where we test the "function" in "functional genomics" by seeing what cells do with evolutionarily naïve DNA. Will they make transcripts? Open chromatin? Histone marks? Find out more at co-1st author @ishikaluthra's tweetorial!
What is the baseline state of our genomes? What are the activities we expect to find by chance? Thrilled to share this pre-print on this intriguing topic that I worked on at the de Boer lab in my undergrad!
How much of the stuff that our genomes do is actually functional? We set out to answer this long debated question by creating a null hypothesis in yeast and human in the de Boer Lab's latest preprint: 1/ https://t.co/lRDyCiPaX2
So proud of Dr. Jingya Qiu! Successfully defended her awesome PhD thesis work where she discovers and describes the role of inflammatory memory in the evolution of cancer immunotherapy resistance. @UPennGCB @jingya_qiu
Here’s our @Nature paper on v deep whole-genome sequencing of serial ctDNA and met tissue. @cherberts1, Matti, Joonatan et al applied new methods to give fascinating insight into temporal #ProstateCancer clonal complexity and evolution of resistance. 1/7 https://t.co/xTqXwj83JP
Excited to announce that we are holding a Machine Learning competition with @DR_E_A_M: predicting gene expression from DNA sequence using >6,000,000 random yeast promoters as training data. More info available on the competition website:
https://t.co/7BqTwqB4Ba
Thanks so much @Eichelbard for featuring me and @JanellaSchwab. It was such a great time chatting about our stories at iGEM - something we really can't stop talking about :)
We are happy to announce that we have won a gold medal along with a nomination of Best Diagnostics Project at #iGEM2021 for our biosensor to profile the tumour microenvironment!
A huge thank you to everyone who helped us during our journey 🧫🧬
#SynBio#detecTME@iGEM
We're honoured and excited to have been nominated for Best Diagnostics project at @iGEM with DetectME, our platform for detection of immune activity in tumours! https://t.co/SwtS8JRsDg #iGEM2021
Learn more about our project at https://t.co/DkirmOkTtr 🧬
Congrats to compsci students @EmiliaCXY and @sarahwng for winning best basic science prize at our dept research day last week, officiated by @Chris_Barbieri1! Their work is all the more impressive as they are undergrads who have never benefitted from normal research immersion 👏