Stephanie Schlichtner, PhD

[Stephanie Schlichtner, PhD @SchlichtnerS]

I am happy to share that my PhD thesis has been now published, focussing on the influence of galectin-9 and its corresponding interaction partners Tim-3 and VISTA on the immunosuppressive function of cancer cells.

@ResearchGate: https://t.co/xfy2iD8Xne

[Stephanie Schlichtner, PhD @SchlichtnerS]

I am very happy to announce that I have successfully defended my #PhD thesis today focussed on the immunosuppressive influence of Tim-3, galectin-9 and Vista by cancer cells against immune cell responses! Looking very much forward to what the future brings next!

[The ICR @ICR_London]

Huge congratulations to One More City who recently completed their 600km cycle from Strasbourg to Munich in just four days for the ICR!

The money will support a second #PhD student researching #SecondaryBreastCancer❤️🚲

#SecondaryBreastCancerAwarenessDay

📷 Saskia Martin

[London Immunology @London_immuno]

⏰ Only a week left until our annual meeting #BSIphagocytes22!!🤩
Join us Wednesday 12 October for an exciting day all about mononuclear phagocytes in health and disease!

Check out our program for full details, and don't forget to register!! https://t.co/oQO3tkdGfk

[EACR @EACRnews]

❗ Less than a week left to register for #CellularBases for Patient Response to Conventional Cancer Therapies! Join us in Berlin for an update on the latest developments on various aspects of cancer progression and therapy resistance https://t.co/pWLRo4FwuO #CancerTherapies

[Lange Nacht der Forschung Österreich @LNF_Austria]

Heute ist es soweit! Erlebt Forschung und Innovation LIVE in ganz Österreich: 280 Standorte, 2.500 Stationen und unendlich viel Wissen warten auf die Besucherinnen und Besucher! #LNF22

[EACR @EACRnews]

🔧 Announcing our new joint conference on Immune Responses & DNA Repair! We've teamed up with @AACR and SIC to present "Immune Responses & DNA Repair - Cancer Fields Converging" in Florence, Italy, 15 - 17 March 2023. More info: https://t.co/XzJrx43Zgo #immuneresponses #DNArepair

[EACR @EACRnews]

🇪🇸 #EACR2022: it's just over a month until we commence in Seville! Join us for discussion on the tumour microbiome, molecular oncology, imaging and tracking cancer, the biology of metastasis and much more! https://t.co/Xym44Q7Vnp #CancerResearch #BasicResearch

[Frontiers - Immunology @FrontImmunol]

New Research: Macrophage Differentiation and Polarization Regulate the Release of the Immune Checkpoint Protein V-Domain Ig Suppressor of T Cell Activation: Recently, the V-domain immunoglobulin suppressor of T-cell activation (VISTA) was… https://t.co/QlZyO835Tl #immunology

[Stephanie Schlichtner, PhD @SchlichtnerS]

Research is available on @ResearchGate: https://t.co/3Ydl3FpCOV

This study is focused on the differential expression of VISTA in human monocytes and macrophages in order to elucidate a putative role of VISTA regulation upon macrophage polarization and activation.

[Fani Papagiannouli @FPapagiannouli]

Interested to know more about the interplay of endo-lysosomal trafficking with polarity and signaling? Check the recent review from our lab! @Medway_Pharmacy @FESGreenwich @UniKent

https://t.co/GUQ7uW9sMo

[Stephanie Schlichtner, PhD @SchlichtnerS]

My research is available on @ResearchGate: https://t.co/KOYtTrvngI

Here we report VISTA expression is controlled by the TGF-β-Smad3 signalling pathway. However, in T lymphocytes we found VISTA expression was differentially regulated by TGF-β depending on their immune profile.

[Stephanie Schlichtner, PhD @SchlichtnerS]

My research is available on @ResearchGate: https://t.co/Cn715nMOVZ
Here we confirmed that soluble galectin-9 binds to Gram-negative bacteria by interacting with LPS forming their cell wall. This opsonisation interferes with the mobility of bacteria leading to phagocytosis.

[Stephanie Schlichtner, PhD @SchlichtnerS]

My research is available on @ResearchGate: https://t.co/1a65jbxgQm
Here we report that the involvement of HMGB1 in anti-cancer immune evasion is determined by TLR4, which recognises HMGB1 as a ligand. We found that HGMB1 induces production of TGF-β and therefore galectin-9.

[Stephanie Schlichtner, PhD @SchlichtnerS]

My research is available on @ResearchGate: https://t.co/oi4J6N3Nt1
Here we report that in human cancer as well as embryonic cells, the transcription factors HIF-1 and AP-1 are involved in autocrine upregulation of TGF-β1/SMAD-3 triggering increase of galectin-9 expression.

[Stephanie Schlichtner, PhD @SchlichtnerS]

My research is available on @ResearchGate: https://t.co/TPPkPChaXn

Here we report for the first time that V-domain Ig-containing suppressor of T cell activation (VISTA), a protein expressed by T cells, recognizes galectin-9 secreted by AML cells as a ligand.