Schwab Lab

Schwab lab at the Department of Neurology - University Clinics Muenster, Germany. Clinical & Translational Neuroimmunology.

[Schwab Lab @Schwab_Lab]

It was a long road, but happy that it’s finally out. The scientific results of our SMILE trial showing that MS patients have a blunted response to UVB light. In them its effects stay in the skin and do not translate systemically. https://t.co/6DLkOLEHnt

[Schwab Lab @Schwab_Lab]

Happy to share our new paper on the effects of Cladribine on the T and Bcell repertoire and how they translate to clinical efficacy. https://t.co/HqLSabIiks

[Schwab Lab @Schwab_Lab]

Our new study shows that natalizumab treatment gap not only changes serum biomarkers (e.g. sVCAM-1), but also (subsequently) CSF composition, suggesting that renewed immune infiltration into the CNS and other tissues might play a role in reducing PML risk. https://t.co/gNpTt2p64f

[Schwab Lab @Schwab_Lab]

Our paper is out: the first genetic treatment response biomarker in MS. A finding only made possible by AIRRseq. This was a truly collaborative effort with @jsabatino37 @hwiendl @AdaptiveBiotech and is a huge step towards personalized medicine.
https://t.co/GHxzSr2oft

[Schwab Lab @Schwab_Lab]

Our new AIRR paper alongside Ocrelizumab, thanks to @NFDI4Immuno and the whole team! https://t.co/4nAwsz0JU2

[Schwab Lab @Schwab_Lab]

The next chapter in our continued effort to understand EBV and MS: Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation https://t.co/GKc7pG3WFz

[Dmitriy M Chudakov @ChudakovM]

Structure-based prediction of T cell receptor recognition of unseen epitopes using TCRen. Yes, it works: https://t.co/A2XJe9Erbt

[Schwab Lab @Schwab_Lab]

Rare diseases need some attention, too.

Chemokine-mediated cell migration into the central nervous system in progressive multifocal leukoencephalopathy: Cell Reports Medicine https://t.co/mfshB29dUr

[Pieter Meysman @chevaliersf]

Glad to finally be able to showcase our #TCR-#epitope annotation tool DETECT and the cool results we have gotten with it at the @airr_community #AIRRC7 conference!
And as of now you can use it yourself!

[ImmunoInformatics @immuno_inform]

AIRR Community Meeting VII – Learnings and Perspectives: https://t.co/RnbtKJm28C

[Brain @Brain1878]

Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA

New scientific commentary by Nicholas Schwab https://t.co/iRx81utwVe

[Schwab Lab @Schwab_Lab]

I wrote a commentary about a new MS CSF scRNAseq study that was recently published in @Brain1878 Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA https://t.co/F1JRbJxQTh

[Roman Sankowski @r_sankowski]

Our #OpenAccess paper on human CNS #macrophages went online today. It was a multi-year collaborative effort between clinician scientists from #Neuropathology #Neurosurgery #Oncology and #gynacology. It struck with the question: what are the phenotypes of human CNS macrophages? /1

[Science Translational Medicine @ScienceTM]

The new special issue of #ScienceTranslationalMedicine is out! This issue features a collection of studies and articles exploring frontiers in #neuroimmunology and the role of the immune system in neurological conditions such as Parkinson's disease.

https://t.co/FyevVOndrS

[Schwab Lab @Schwab_Lab]

I wrote a review in @ScienceTM with my long-time collaborator @hwiendl about what we can learn about CNS immunity when we look closely at patients treated with interventions that target BBB trafficking. https://t.co/4vBXNmHOoF

[Joe Sabatino @jsabatino37]

Beautiful example of bedside -> bench -> bedside #Tcell immunology for the treatment of #autoimmunity

https://t.co/fLSn3GuQeu

[Schwab Lab @Schwab_Lab]

At this year’s ECTRIMS in Milano with the team #MSMilan2023

[Ulrik Stervbo (He/Him) @UlrikStervbo]

Also included is an exciting session devoted to identify the obstacles in turning AIRR-seq into a diagnostic tool

[airr_community @airr_community]

A new episode of #OnAIRR - the podcast of the AIRR Community is available. We discuss AIRR-seq, machine learning and disease diagnostics with @zazius, @ScottBoydLab. Subscribe and listen in your favourite app or grab the episode here: https://t.co/btLfI1hi0P

[airr_community @airr_community]

A new episode of #OnAIRR - the podcast of the AIRR Community is available. Prof Xenophon Papademetris, @YaleRadiology, USA, introduces Software as a Medical Device. Subscribe and listen in your favourite app or grab the episode here: https://t.co/btLfI1hi0P