ASCI member Coffey et al. @VUMChealth establish DPEP1’s importance in maintaining microsatellite stable colorectal cancer, and its ability to shape the tumor microenvironment: https://t.co/kzVHxtmG9Y
🧬 A 2025 JCI Insight study from Vanderbilt used LSALT peptide to reduce neutrophil binding to colorectal cancer (CRC) cells, highlighting DPEP1’s immune role.
The authors suggest LSALT could pair with ICI (immune checkpoint inhibitors) and could lead to a viable therapeutic. Arch holds patents for its DPEP1 inhibition drug candidates, including LSALT peptide, covering use in cancer applications.
🔗 https://t.co/MKdAA7iOoB
#LSALTpeptide #DPEP1 #ArchScience $ARCH.V $ACHFF
🔬 New research in @JCI_insight by @SciComSarah, @VanderbiltCDB shows that removing a single protein, DPEP1, can dramatically change how #coloncancer develops—leading to more aggressive tumors that resemble a type more responsive to immunotherapy. 👉 https://t.co/kIQafv6KwZ