Science Signaling

Science Signaling offers researchers the most up-to-date resource for groundbreaking research and commentary in the dynamic field of cellular signaling.

[Science Signaling @scisignal]

Researchers connect #osteoarthritis to a lack of the enzyme TIKI2 in cartilage and show that TIKI2 normally supports cartilage integrity and homeostasis by promoting chondrocyte differentiation and restraining Wnt signaling pathways. @2024_HUST https://t.co/tnmyjpu7my

[Science Signaling @scisignal]

This week’s new issue of #ScienceSignaling has arrived!

A team identifies a gatekeeper of cartilage health that goes awry in osteoarthritis, a Review highlights how cell nutrition is emerging as a pillar of fitness for unconventional T cells, and more. https://t.co/PWHnhUAdkh

[Science Signaling @scisignal]

Contrary to current thinking, a new study shows that activation of the #VagusNerve results in decreased insulin release from the pancreas—and that #obesity exacerbates this dampening effect. @KanazawaUniv_O @Tokushima_Univ https://t.co/h7x4FxGIQg

[Science Signaling @scisignal]

The dsDNA sensor #cGAS drives damaging immune responses and acute lung injury during infection via #phosphorylation triggered by double-stranded DNA, a rapid spike in Ca2+, and formation of cGAS condensates in endothelial cells. @dollymehtalab @uiccom https://t.co/W633uNrCA0

[Science Signaling @scisignal]

Recent work reveals how two proteins enhance signaling pathways mediated by receptor tyrosine kinases (RTKs) that drive many cancers and points to possible strategies to target RTK-driven #cancers that have developed resistance to RTK inhibitors. @CWRUSOM https://t.co/AokQiqBeRQ

[Science Signaling @scisignal]

In this week’s Editors’ Choice piece, we highlight a study by Torborg and colleagues in @Dev_Cell, revealing insights into how Wnt signaling regulates PDAC tumor growth.

Read a summary: https://t.co/Nuk2RfWuwT

[Science Signaling @scisignal]

Researchers have traced the molecular origins of severe pain in #neurofibromatosis—an inherited condition of tumors in the nervous system—and show that an FDA-approved drug can relieve pain in mice. @CincyChildrens @NamrataGRRaut @JankowskiLab https://t.co/bT1KlYZ0Zz

[Science Signaling @scisignal]

An in vivo and modeling analysis shows that activity of the vagus nerve has a more complex effect on insulin release than was previously thought, hinting vagus nerve stimulation may have unintended metabolic consequences. @KanazawaUniv_O @Tokushima_Univ https://t.co/h7x4FxGIQg

[Science Signaling @scisignal]

How does neurofibromatosis cause pain?

New work shows that #SchwannCells drive pain sensitivity in mice by secreting GDNF that activates GFR-alpha-1 on sensory neurons, which can be reversed with mirdametinib. @CincyChildrens @NamrataGRRaut @JankowskiLab https://t.co/bT1KlYZ0Zz

[Science Signaling @scisignal]

Scientists trace the molecular origins of severe pain in neurofibromatosis, surprising results in mice reveal how obesity alters how the vagus nerve regulates insulin release, and more this week in #ScienceSignaling. https://t.co/WCZT2slt1u

[Science Signaling @scisignal]

New work reveals how two proteins enhance signaling pathways mediated by receptor tyrosine kinases (RTKs) that drive many cancers and points to possible strategies to target RTK-driven #cancers that have developed resistance to RTK inhibitors. @CWRUSOM https://t.co/AokQiqBeRQ

[Science Signaling @scisignal]

Through structural and functional assays, scientists have revealed an important regulatory role for the transmembrane domain of the receptor for TNF, a clinically relevant inflammatory cytokine. @WEHI_research https://t.co/ScGUuHtzLe

[Science Signaling @scisignal]

A recent study visualizes the ebb and flow of receptors within neurons via the unusual process of #transcytosis—helping answer how these cells maintain their function and connectivity in vivo despite their spindly, elongated nature. @JohnsHopkins https://t.co/EL8DuNMk0O

[Science Signaling @scisignal]

New experiments performed in vitro and in mice clarify the molecular origins of uncontrolled inflammatory immune responses in the lungs—a common and severe complication of lung infections. @dollymehtalab @uiccom #InnateImmunity https://t.co/W633uNrCA0

[Science Signaling @scisignal]

An unbiased analysis of #ReceptorTyrosineKinase pathways in cell lines reveals that GOLPH3 and its binding partner MYO18 promote the movement of RTKs to the cell surface, poising them to respond to growth factors and amplify oncogenic signaling. @CWRUSOM https://t.co/AokQiqBeRQ

[Science Signaling @scisignal]

The dsDNA sensor #cGAS drives damaging immune responses and acute lung injury during infection via #phosphorylation triggered by double-stranded DNA, a rapid spike in Ca2+, and formation of cGAS condensates in endothelial cells. @dollymehtalab @uiccom https://t.co/W633uNrCA0

[Science Signaling @scisignal]

Don’t miss the new issue of #ScienceSignaling!

A new study reveals how the DNA sensor cGAS drives collateral damage in the lungs during infections, experiments delineate how a pair of proteins routes receptors for signaling in cancer cells, and more. https://t.co/lWqY7BTLc7

[Science Signaling @scisignal]

Through structural and functional assays, scientists have revealed an important regulatory role for the transmembrane domain of the receptor for TNF, a clinically relevant inflammatory cytokine. @WEHI_research https://t.co/ScGUuHtzLe

[Science Signaling @scisignal]

As we approach the 25th anniversary of #lipidomics, a Focus discusses how the community-driven databases, software, and educational resources at LIPID MAPS will propel further progress in this important research field. @CUSystemsImmu https://t.co/38cpjpL8KY

[Science Signaling @scisignal]

Employing protein tagging, scientists identify interaction networks centered on the #p38 homolog PMK-1 in C. elegans that facilitate phenotypic plasticity during development, in several tissue types, and in response to stresses and aging. @UTSWMedCenter https://t.co/QFzUV2lNpL