Science Translational Medicine

Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine.

[Science Translational Medicine @ScienceTM]

A new Review synthesizes the translational pipeline of research decoding how tumors interact with both the central and peripheral nervous systems to fuel their growth—as well as implications for drug repurposing and interventions. @UTMDAnderson https://t.co/egAnBZZNSp

[Science Translational Medicine @ScienceTM]

In an Editorial, researchers introduce a special issue on cancer #neuroscience, and discuss the broad arc of research discoveries that have illuminated how cancers hijack the nervous system. @matipittarello @NeurosurgUCSF https://t.co/dA7WYWmg6T

[Science Translational Medicine @ScienceTM]

The expansion of CD4+ #CART cells drives unusual neurotoxicities in patients with #MultipleMyeloma who are taking #ciltacabtagene autoleucel (cilta-cel), according to new work in a new special issue. @MSKCancerCenter https://t.co/JX1iRrr4Wo

[Science Translational Medicine @ScienceTM]

An advanced wearable with motor sensors captures growth metrics and motor growth charts in infants playing at home over the course of more than a year—offering an unparalleled ability to track early patterns in motor and neurodevelopment. @helsinkiuni https://t.co/Qs2MRq5aP8

[Science Translational Medicine @ScienceTM]

An analysis of patient data and mice untangles how sympathetic and sensory nerve crosstalk drives progression of oral cancer and triggers neuropathic pain by raising adrenergic sensitivity and peripheral neuroplasticity. @nicole_scheff @PittTweet https://t.co/QV37MIa8EG

[Science Translational Medicine @ScienceTM]

A liposomal nanoparticle therapeutic takes advantage of temporary blood-brain barrier disruption after surgical resection of #glioblastoma tumors to penetrate margins and deliver drugs such as doxorubicin, according to new preclinical work. @FBMH_UoM https://t.co/yeM7xqiaft

[Science Translational Medicine @ScienceTM]

Don't miss this week's special issue of #ScienceTranslationalMedicine—featuring a deep dive into the latest cancer neuroscience research. A collection of Research Articles, Reviews, and Viewpoints dissects this emerging field and its clinical implications: https://t.co/Il2mMfxDuE

[Science Translational Medicine @ScienceTM]

New single-cell analyses decrypt how hematopoietic stem cells in #SickleCellDisease display signs of #senescence such as DNA damage and cell cycle disruptions, and show that senolytic drugs can restore function in vivo and ex vivo. @StJudeResearch https://t.co/Vs95lg3oNI

[Science Translational Medicine @ScienceTM]

A pair of live-attenuated vaccines for #YPestis can protect mice from pneumonic plague by stimulating humoral and cellular immunity—and surprisingly still provides robust protection in mice lacking the cytokine interferon-gamma. @utmbhealth https://t.co/4x7YM7S7Rl

[Science Translational Medicine @ScienceTM]

A team untangles the immune mechanisms connecting #EBV to #MultipleSclerosis, showing that CD4+ T cells from patients respond to viral particle components and that this response can be calmed with B cell-depleting therapy. @KjetilBjornevik @HarvardChanSPH https://t.co/wg2zFlegO9

[Timothée Bruel @Timothee_B]

1/ 🧵Thrilled to share that our new paper was just published at @ScienceTM @aaas ! 🎉

We show how the complement system boosts the ability of antibodies to neutralize SARS-CoV-2, especially recent variants. 🦠🧫

https://t.co/3wheB6bJhu

A thread ⬇️

[Meher Angez @meher_angez]

Excited to see one of my all-time favorite projects finally published in @ScienceTM Medicine! 🎉
I had the opportunity to join this project during my final-year medical school. So grateful to my mentor Dr. Amyn Habib for the opportunity. https://t.co/935QzX63Zz

[Science Translational Medicine @ScienceTM]

An in-depth analysis of a phase 3 trial of youths with type 1 #diabetes combines RNA seq, kidney MRI, and proteomics to probe how the SGLT2 inhibitor dapagliflozin counteracts the hallmarks of diabetic kidney disease. @PBjornstadMD @UWEndocrinology https://t.co/Yb3xmuG2fh

[Science Translational Medicine @ScienceTM]

An advanced wearable with motor sensors captures growth metrics and motor growth charts in infants playing at home over the course of more than a year—offering an unparalleled ability to track early patterns in motor and neurodevelopment. @helsinkiuni https://t.co/Qs2MRq5aP8

[Science Translational Medicine @ScienceTM]

The new issue of #ScienceTranslationalMedicine is out now!

An at-home wearable jumpsuit captures motor development patterns in playing infants, a phase 3 trial reveals how an approved drug may treat kidney disease in youth with type 1 diabetes, and more. https://t.co/SsXHZtqnQj

[Science Translational Medicine @ScienceTM]

By comparing drug-induced gene expression patterns in the striatum, a team identifies the cardiac drug SB-0107 as a potential adjunct therapy for #ParkinsonsDisease that boosts L-DOPA’s benefits in macaques while mitigating dyskinesia. @aa_bordba https://t.co/1EFEiCvplL

[Science Translational Medicine @ScienceTM]

Applying bulk and single-cell #RNAsequencing, a team identifies PTEN as a driver of endothelial, lymph endothelial, and immune cell dysfunction in nonhealing venous leg ulcers in patients, suggesting PTEN inhibition as a possible intervention. @umfrostderm https://t.co/VOLGNpdTOs

[Science Translational Medicine @ScienceTM]

Scientists isolate a bacteriophage that switches off a key virulence mechanism in adherent #Ecoli that drive Crohn's disease, and can attenuate #colitis in mice and augment the efficacy of low doses of budesonide. @VerduLab @Kyle_EH_Jackson @Farncombe_GI https://t.co/MTGhy65wiO

[Science Translational Medicine @ScienceTM]

Intracortical microstimulation electrodes are safe and produce consistent sensations for as long as a decade in patients with spinal cord injury, supporting their utility in #BrainComputer interface interventions. @CMGreenspon @robert_gaunt1 @UChicago https://t.co/Jo2GxKbYQG

[Science Translational Medicine @ScienceTM]

A team untangles the immune mechanisms connecting #EBV to #MultipleSclerosis, showing that CD4+ T cells from patients respond to viral particle components and that this response can be calmed with B cell-depleting therapy. @KjetilBjornevik @HarvardChanSPH https://t.co/wg2zFlegO9