Science Translational Medicine

Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine.

[Science Translational Medicine @ScienceTM]

An advanced wearable with motor sensors captures growth metrics and motor growth charts in infants playing at home over the course of more than a year—offering an unparalleled ability to track early patterns in motor and neurodevelopment. @helsinkiuni https://t.co/Qs2MRq5aP8

[Science Translational Medicine @ScienceTM]

An analysis of patient data and mice untangles how sympathetic and sensory nerve crosstalk drives progression of oral cancer and triggers neuropathic pain by raising adrenergic sensitivity and peripheral neuroplasticity. @nicole_scheff @PittTweet https://t.co/QV37MIa8EG

[Science Translational Medicine @ScienceTM]

A liposomal nanoparticle therapeutic takes advantage of temporary blood-brain barrier disruption after surgical resection of #glioblastoma tumors to penetrate margins and deliver drugs such as doxorubicin, according to new preclinical work. @FBMH_UoM https://t.co/yeM7xqiaft

[Science Translational Medicine @ScienceTM]

Don't miss this week's special issue of #ScienceTranslationalMedicine—featuring a deep dive into the latest cancer neuroscience research. A collection of Research Articles, Reviews, and Viewpoints dissects this emerging field and its clinical implications: https://t.co/Il2mMfxDuE

[Science Translational Medicine @ScienceTM]

New single-cell analyses decrypt how hematopoietic stem cells in #SickleCellDisease display signs of #senescence such as DNA damage and cell cycle disruptions, and show that senolytic drugs can restore function in vivo and ex vivo. @StJudeResearch https://t.co/Vs95lg3oNI

[Science Translational Medicine @ScienceTM]

A pair of live-attenuated vaccines for #YPestis can protect mice from pneumonic plague by stimulating humoral and cellular immunity—and surprisingly still provides robust protection in mice lacking the cytokine interferon-gamma. @utmbhealth https://t.co/4x7YM7S7Rl

[Science Translational Medicine @ScienceTM]

A team untangles the immune mechanisms connecting #EBV to #MultipleSclerosis, showing that CD4+ T cells from patients respond to viral particle components and that this response can be calmed with B cell-depleting therapy. @KjetilBjornevik @HarvardChanSPH https://t.co/wg2zFlegO9

[Timothée Bruel @Timothee_B]

1/ 🧵Thrilled to share that our new paper was just published at @ScienceTM @aaas ! 🎉

We show how the complement system boosts the ability of antibodies to neutralize SARS-CoV-2, especially recent variants. 🦠🧫

https://t.co/3wheB6bJhu

A thread ⬇️

[Meher Angez @meher_angez]

Excited to see one of my all-time favorite projects finally published in @ScienceTM Medicine! 🎉
I had the opportunity to join this project during my final-year medical school. So grateful to my mentor Dr. Amyn Habib for the opportunity. https://t.co/935QzX63Zz

[Science Translational Medicine @ScienceTM]

An in-depth analysis of a phase 3 trial of youths with type 1 #diabetes combines RNA seq, kidney MRI, and proteomics to probe how the SGLT2 inhibitor dapagliflozin counteracts the hallmarks of diabetic kidney disease. @PBjornstadMD @UWEndocrinology https://t.co/Yb3xmuG2fh

[Science Translational Medicine @ScienceTM]

An advanced wearable with motor sensors captures growth metrics and motor growth charts in infants playing at home over the course of more than a year—offering an unparalleled ability to track early patterns in motor and neurodevelopment. @helsinkiuni https://t.co/Qs2MRq5aP8

[Science Translational Medicine @ScienceTM]

The new issue of #ScienceTranslationalMedicine is out now!

An at-home wearable jumpsuit captures motor development patterns in playing infants, a phase 3 trial reveals how an approved drug may treat kidney disease in youth with type 1 diabetes, and more. https://t.co/SsXHZtqnQj

[Science Translational Medicine @ScienceTM]

By comparing drug-induced gene expression patterns in the striatum, a team identifies the cardiac drug SB-0107 as a potential adjunct therapy for #ParkinsonsDisease that boosts L-DOPA’s benefits in macaques while mitigating dyskinesia. @aa_bordba https://t.co/1EFEiCvplL

[Science Translational Medicine @ScienceTM]

Applying bulk and single-cell #RNAsequencing, a team identifies PTEN as a driver of endothelial, lymph endothelial, and immune cell dysfunction in nonhealing venous leg ulcers in patients, suggesting PTEN inhibition as a possible intervention. @umfrostderm https://t.co/VOLGNpdTOs

[Science Translational Medicine @ScienceTM]

Scientists isolate a bacteriophage that switches off a key virulence mechanism in adherent #Ecoli that drive Crohn's disease, and can attenuate #colitis in mice and augment the efficacy of low doses of budesonide. @VerduLab @Kyle_EH_Jackson @Farncombe_GI https://t.co/MTGhy65wiO

[Science Translational Medicine @ScienceTM]

Intracortical microstimulation electrodes are safe and produce consistent sensations for as long as a decade in patients with spinal cord injury, supporting their utility in #BrainComputer interface interventions. @CMGreenspon @robert_gaunt1 @UChicago https://t.co/Jo2GxKbYQG

[Science Translational Medicine @ScienceTM]

A team untangles the immune mechanisms connecting #EBV to #MultipleSclerosis, showing that CD4+ T cells from patients respond to viral particle components and that this response can be calmed with B cell-depleting therapy. @KjetilBjornevik @HarvardChanSPH https://t.co/wg2zFlegO9

[Science Translational Medicine @ScienceTM]

New work elucidates how Epstein-Barr virus may provoke T cells to drive multiple sclerosis, a brain-computer interface that restores touch is safe in humans for many years, and more in the new issue of #ScienceTranslationalMedicine. https://t.co/wS1vnEo0lj

[Science Translational Medicine @ScienceTM]

A study of T cells from patients with #lupus #nephritis shows these cells are activated by local cytokines and could mediate injury in inflamed kidneys, with some T cells reactive to potentially latent #EpsteinBarr and #CMV. @ChariteBerlin @P_Enghard https://t.co/ZsBonNd4eC

[Science Translational Medicine @ScienceTM]

A genetic study of nearly 2700 congenital cerebral ventriculomegaly (#CCV) hydrocephaly patients finds 25% of them have protein-damaging mutations, many of which are linked to neurodevelopmental disorders such as #ASD. @PiN_Harvard @KahleKristopher https://t.co/0O0YRtjKNy