The Science of Parkinson's

Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂

[The Science of Parkinson's @ScienceofPD]

The Science of #Parkinsons will be out of office for the next few day

Behave yourselves

[The Science of Parkinson's @ScienceofPD]

‘To Hear and Be Heard’
The co-design of a website to support communication challenges experienced by people With #Parkinsons & their families & friends
https://t.co/RurlimHceu

[The Science of Parkinson's @ScienceofPD]

There is a special issue of the @journal_PD providing the proceedings of the 7th World #Parkinsons Congress @WorldPDCongress
https://t.co/LfBQIGDNx1

[The Science of Parkinson's @ScienceofPD]

Single-nucleus phosphatome rewiring & phosphoproteomics reveal PFKFB2 as an LRRK2-linked metabolic node in the human Substantia Nigra of #Parkinsons patients
https://t.co/tte2QXiEeH

[The Science of Parkinson's @ScienceofPD]

Interesting new @biorxivpreprint: Frontal stimulation reshapes SCAN connectivity & improves motor function in #Parkinsons
https://t.co/EPwvr8lcY4

[The Science of Parkinson's @ScienceofPD]

Everything you ever wanted to know about human DOPA Decarboxylase - from monoamine metabolism, pharmacology, & synucleinopathies; "AADC measured in cerebrospinal fluid has emerged as one of the most discriminating fluid biomarkers for #Parkinsons & LBD"
https://t.co/KvaDZhxTaL

[The Science of Parkinson's @ScienceofPD]

Researchers present evidence for the involvement of laterodorsal tegmental nucleus-ventral part (the putative human homologue of the murine sublaterodorsal nucleus) in isolated REM sleep behaviour disorder (Structural MRIs; n=98 iRBD & 114 controls)
https://t.co/qiREyyofgr

[The Science of Parkinson's @ScienceofPD]

New review examines the role of mitochondrial biomarkers in improving diagnostic accuracy, patient stratification & monitoring of disease progression & therapeutic response across neurology (including a useful section on #Parkinsons)
https://t.co/E4UzH6GGbX

[The Science of Parkinson's @ScienceofPD]

New data finds that in patients with #Parkinsons & neurogenic orthostatic hypotension (OH), ambulatory hypertensive episodes were associated with better clinical outcomes, an association not observed in patients with non-neurogenic OH
https://t.co/7XF5u3KnSC

[The Science of Parkinson's @ScienceofPD]

Researchers use PPMI data to identify a 7-protein cerebrospinal fluid (CSF) proteomic signature (CCL27, CXCL9, NEFL, SERPINE1, GH1, TYMP, KLK1) that exhibited good discriminative performance for distinguishing rapid from slow #Parkinsons progressors
https://t.co/a193L6e6Io

[The Science of Parkinson's @ScienceofPD]

Researchers present "DPEU" - a small-molecule modulator of VDAC function that promotes ATP flux in β cells through a mechanism distinct from the classical KATP or cAMP pathways, identifying VDAC as a potential target for enhancing insulin secretion
https://t.co/I85ismFuw1

[The Science of Parkinson's @ScienceofPD]

Researchers report the first potent & selective covalent inhibitor of USP32 together with the first cell-permeable activity-based probes for this deubiquitinase
https://t.co/f8dKVS5efE

[The Science of Parkinson's @ScienceofPD]

A study of chronic rotenone administration (21 days) in mice finds #Parkinsons-like behaviour after 4 weeks, but "after 12 months of toxin cessation, rotenone-treated mice exhibited behavioral performance & TH expression levels" comparable to controls
https://t.co/6JLbfvmddu

[The Science of Parkinson's @ScienceofPD]

An international group of leading microbiome scientists, convened by the @HHSGov, presents a strategic vision for realizing its potential to transform public health. They outline 10 strategic priorities for research and public health
https://t.co/Pf8ylDV8KP

[The Science of Parkinson's @ScienceofPD]

New research identifies USP18 as a potential regulator of ferroptosis in #Parkinsons & "reveal the central role of the USP18–SLC7A11 axis in dopaminergic neuronal loss, suggesting that USP18 holds promise as a potential therapeutic target for PD"
https://t.co/Mos5a04rER

[The Science of Parkinson's @ScienceofPD]

Researchers identify candidate markers for the isolation of neuron-specific extracellular vesicles, with Neurexin 3 (NRXN3) being highlighted - even in a small pilot study of #Parkinsons samples (no difference with controls)
https://t.co/GTfFnVGvoX

[The Science of Parkinson's @ScienceofPD]

More weekend reading: New review explores cytokine circuits in CNS homeostasis; "CNS cytokine circuits may also be shaped by systemic immune & metabolic cues, whose influence on local cytokine production & responsiveness remains incompletely understood"
https://t.co/Ma0NE3cUIo

[The Science of Parkinson's @ScienceofPD]

Weekend reading: New review examines gut dysbiosis, tryptophan metabolism, & aryl hydrocarbon receptor signaling as potential mechanisms underlying idiopathic #Parkinsons & highlights their relevance to early diagnosis and disease-modifying therapies
https://t.co/YwQfUzVvXn

[The Science of Parkinson's @ScienceofPD]

New nationwide (South Korea) cohort study suggests a potential association between higher cumulative proton pump inhibitor exposure (≥ 180 days of use) & an increased risk of #Parkinsons
https://t.co/lvnzq3REkB

[The Science of Parkinson's @ScienceofPD]

Researchers propose a new model based on complementary MRI modalities to provide an objective clinical decision-support measure for #Parkinsons with potential applications in other parkinsonisms (multiple system atrophy, progressive supranuclear palsy)
https://t.co/SC3sYuT22p