The Science of Parkinson's

Personal account of the Director of Research at @CureParkinsonsT - All views my own - Kiwi - Kia kaha - 侘寂

[The Science of Parkinson's @ScienceofPD]

New preclinical findings reveal a functional interplay between daily biological timing & lysosomal enzyme regulation, suggesting that optimizing drug dosing & timing of administration may improve the efficacy of GCase-targeted treatments
https://t.co/4Gb4BsGZvt

[The Science of Parkinson's @ScienceofPD]

Proof-of-principle targeting with antisense oligonucleotides demonstrates the feasibility of a cost-effective & scalable approach for allele-specific sequencing of ATXN3 in individual patients & larger Spinocerebellar ataxia type 3 (SCA3) cohorts
https://t.co/OJe4QWrdeF

[The Science of Parkinson's @ScienceofPD]

A new qualitative, ethnographic study from @TashMisbah investigates family & community care for older persons with #Parkinsons in Kenya; “They wonder, ‘you’ve been to the doctor, & you’re not healed’?"
https://t.co/zkBYzeTKMb

[The Science of Parkinson's @ScienceofPD]

Interesting press summary about a new Mayo Clinic study investigating whether low-dose radiation therapy can slow the progression of #Parkinsons by targeting inflammation in areas of the brain affected by the disease
https://t.co/6TFp9IPrZC

[The Science of Parkinson's @ScienceofPD]

AbbVie pumps up the economic case for early subcutaneous #Parkinsons
https://t.co/KuTrDFkIE1

[The Science of Parkinson's @ScienceofPD]

Researchers observe elevated taurochenodeoxycholic acid (TCDCA) in #Parkinsons patients which correlates with disease severity. TCDCA treatment exacerbates rotenone-induced PD mouse model. L. reuteri supplementation⬇️TCDCA & alleviates PD mouse model
https://t.co/TzHx3A2THO

[The Science of Parkinson's @ScienceofPD]

"This is particularly relevant to #Parkinsons, where dysregulated dopaminergic signaling, mitochon. dysfunc. & activation of the cGAS-STING pathway are prominent features & is linked with the⬆️release of damaged mtDNA from peripheral blood mononuclear cells from patients with PD"

[The Science of Parkinson's @ScienceofPD]

Researchers report dopamine⬆️the release of inflammatory cytokine IL-6 in human macrophages in a receptor-dependent manner. Dopamine triggers mitochon. dysfunction & mtDNA release to activate cGAS-STING signaling AND induces a metabolic shift to glycolysis
https://t.co/lMD6ik3n1x

[The Science of Parkinson's @ScienceofPD]

New clinical trial registered: An open-label study evaluating brain α-synuclein deposition using XingImaging's PET tracer [¹⁸F]MK-0947 in 18 participants with #Parkinsons
https://t.co/sUy3vLFFgG

[The Science of Parkinson's @ScienceofPD]

New clinical trial registered: Ginger-PD: Ginger as a Modifier of Ghrelin Levels & Gut Function in #Parkinsons (Ginger-PD); @Marta__Camacho & colleagues are looking for 24 people with PD, 24 REM Sleep Behaviour Disorder, & 24 controls; 12-week study
https://t.co/pl2gGWdzkO

[The Science of Parkinson's @ScienceofPD]

"A form of #Parkinsons once considered rare is far more common in Pacific communities than previously recognised. Researchers estimate >400 Pasifika people in NZ could be living with a genetic form of the condition linked to a variant in the PINK1 gene"
https://t.co/UwVVinrCu5

[The Science of Parkinson's @ScienceofPD]

New research finds the transcription factor B-cell lymphoma/leukemia 11B (BCL11B) is a key regulator of neuroinflammation & dopaminergic survival in models of #Parkinsons; BCL11B promotes neurotoxicity via JAK2/STAT3 activation, inhibition=neuroprotection
https://t.co/5pv2MOL8gA

[The Science of Parkinson's @ScienceofPD]

New research from @neumann_wj et al finds a temporal dissociation within the cortex–basal ganglia network, whereby fast cortical transmission is unaffected by dopamine, which in turn amplifies slower network level communication to the subthalamic nucleus
https://t.co/iql5RMNmRB

[The Science of Parkinson's @ScienceofPD]

Researchers find evidence for shared genomic loci (BIN3, MSRA & TNK2 get highlighted) between #Parkinsons & kidney function, offering specific loci & biological pathways for future investigation of the kidney-brain axis in neurodegeneration
https://t.co/tG3LvjXXjy

[The Science of Parkinson's @ScienceofPD]

Nice editorial from @pfeffersuzanne regarding this research:
https://t.co/FOJchCJqpi

[The Science of Parkinson's @ScienceofPD]

New research identifies lysosomal remodeling based on the lysosomal chloride/proton antiporter ClC-7 & Rab accumulation as key features linking PIKfyve inhibition to LRRK2 signaling; Different combinations of Rab & GABARAP inputs activate LRRK2
https://t.co/5bBK3XJLAr

[The Science of Parkinson's @ScienceofPD]

Genetic silencing of Abca1 in either astrocytes or dopaminergic neurons attenuates neurodegeneration & behavioral deficits in #Parkinsons models. Plus, magnesium citrate is identified as an ABCA1 inhibitor & reduced dopaminergic neuronal loss in a PD mouse model

[The Science of Parkinson's @ScienceofPD]

New day, new cholesterol story: Researchers report astrocytic ATP-binding cassette transporter A1 (ABCA1) activity drives excessive cholesterol efflux (in mice), promoting neuronal cholesterol overload. ABCA1 is⬆️in substantia nigra of #Parkinsons brains
https://t.co/fF3GF3kRiy

[The Science of Parkinson's @ScienceofPD]

"Mechanistically, astrocytic ABCA1 drives excessive cholesterol efflux in mice, promoting neuronal cholesterol overload. In neurons, ABCA1 localizes to lysosomes, where it facilitates cholesterol import, leading to cholesterol accumulation, autophagy impairment & α-syn pathology"

[The Science of Parkinson's @ScienceofPD]

Wonderful short film from Zaina Khan exploring young onset #Parkinsons (@CamilleBCarroll, @Ladybale & yours truly make cameos)
https://t.co/1PCDzAelFW