Samantha McNeill 💡🔬💊

Passionate scientist with a huge appreciation for the small things in life (like proteins).

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

Very grateful to work as part of a collaborative team led by Denise Wootten & Patrick Sexton and for generous collaborators who provided us with cell lines they generated (I'm not good at twitter and don't know how to tag sorry, 5/5).

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

However, until this paper, it remained to be determined whether GRKs were essential for GLP-1R internalisation. By using cells which lack beta arrestins or GRKs, we reveal that the GLP-1R internalises via a GRK-dependent, but beta arrestin-independent mechanism (3/n).

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

Interestingly, we also observed that beta arrestin 1 recruitment to the GLP-1R was more sensitive to GRK expression than beta arrestin 2 recruitment (4/n).

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

Unlike many other GPCRs, the GLP-1R has been established to internalise via mechanisms that do not require beta arrestins (2/n).

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

Very excited to share our most recent publication: https://t.co/70nGi3JlLF. Do you like GRKs and the GLP-1R?! Then this paper might be worth a read (1/n).

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

@ppelvazhao What a tasty looking cake!

[Brian P. Cary @brianpcary]

The final version of our manuscript including structures of PTH1R bound to five peptides is live in @Structure_CP! @MIPS_DDB @CCeMMP

[MPGPCR @DDB_MPGPCR]

Save the date! We are excited to once again bring together the international GPCR community to share the latest in #GPCR research. Mark your calendars for November 15-17th, to join us at @MIPS_Australia

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

@NerdyCammy Oh wow! I can't believe star trek day has come around so quickly this year 😂

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

One of the most passionate and generous scientists I know!

[Elva Zhao @ppelvazhao]

😀😀 Hi! This is Elva @HRM_MIPS @MIPS_DDB 🫣🤗

[NHMRC @nhmrc]

This piece by @SarahJ_Piper (@PiperProteins) from @MIPS_Australia and @CCeMMP, was runner up for the NHMRC Science to Art Award. ‘Atomic Jewellery’ shows the atomic structure of a receptor, which helps inform research for the development of therapeutics for diabetes and obesity.

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

@ppelvazhao @MIPS_DDB They clearly heard the rumour of how great you are :).

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

@ppelvazhao This is a very premium poster

[Sketching Science @sketchscience]

I hated doing PCRs 🧬 as an undergraduate… Now, as a postdoc, I’ve done thousands of PCRs 🧬… Here are 10 tips to do perfect PCRs:

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

@RachaelHasIdeas L

[Ardem Patapoutian @ardemp]

We depend on external validation whether we admit it or not. After the @NobelPrize I feel more free, care less about external validation (duh!), and enjoy the process of discovery even more. In retrospect, I think I should have been able to achieve some of this without the Prize!

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

Grateful for this bunch! Here's to more science-filled lunches in 2023

[Elva Zhao @ppelvazhao]

Positive feedback from our very first lawn conference : "Thanks to the organising committee inviting all of us plenary speakers. The event was filled with great debate, including the allocation of Spongebob characters to members of the lab ;) we all learnt a lot!" @MIPS_DDB

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

@ppelvazhao you're the best Elva 🥰

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

@PatrickMSexton1 Great sampling of the free energy landscape of conference attendees

[Samantha McNeill 💡🔬💊 @Scientist__Sam]

This is a very refreshing discussion around leadership in science https://t.co/EN9Qf2x2ZO. Working in science is a privilege, but also a big responsibility. The ability to listen to others and acknowledge when mistakes are made is vital to leadership.