Scott Becker

Co-founder, CBO @ Delve Therapeutics. Former VP Enterprise Products @ Schrodinger. Former Co-Founder, CTO @ Invite Media.

[Adam Feuerstein ✡️ @adamfeuerstein]

$LLY buyinng $MORF $3.2B - oral integrin for inflammatory bowel disease.

$57 per share. 78% premium.

https://t.co/0WLgshUZ3A

[Scott Becker @scottbecker]

@AnExpertOne1 It also reported: "Persistence of the TCR-T cells has been observed. Patient 1 had persistence at 24 weeks with approximately 30% of the patient's total CD3+ T cells comprising TCR-T cells"

[Scott Becker @scottbecker]

@AnExpertOne1 has $TCRT revealed data from biopsies of progressive lesons? If so, have they discussed whether targeted HLA allele and tumor antigen are both still present?

[Scott Becker @scottbecker]

@AnExpertOne1 I found the answer for at least one patient here - "At six months following treatment, an elective tumor biopsy of non-measurable disease in the right lung showed continued presence of tumor cells, KRAS­G12D mutation and HLA-A*11:01 allele" https://t.co/1OmXTYM2P9

[Scott Becker @scottbecker]

@hsalis Try https://t.co/OWI7OTGZrB

[Scott Becker @scottbecker]

@aryelipman Probably easier to sell cheaper widgets than a widget making machine. You will need to go through an RFQ process and wait several months to find that the widget operations manager's manager's manager doesn't have budget available for widget machines at this time.

[Scott Becker @scottbecker]

@Aiims1742 @EileenMOReilly @MSKCancerCenter @ElicioTx Did they check if the response rate correlates with certain HLA types being present?

[Scott Becker @scottbecker]

@johnefinance UHOne plans are short term though, right? (max 3 years)

[Scott Becker @scottbecker]

Transplus though from alstem seems to be working for Jurkat cell transduction - https://t.co/UjS2iKdAa8

[Scott Becker @scottbecker]

Lab tip - BX795 @ 1uM can boost lentivirus transduction efficiency in hard to transduce cell lines by ~2.7x. We were inspired by this paper that showed BX795 boosts mammalian transfection efficiency. https://t.co/QA2O4mK2Q8

[Scott Becker @scottbecker]

After more repeats, we can't reproduce this anymore unfortunately. In fact we are now seeing that BX795 reduces transduction efficiencies and viability in some cell lines.

[Kyle Vogt @kvogt]

Thrilled to announce that the California Public Utilities Commission just approved @Cruise for fared operation 24/7 across all of San Francisco!

It’s a huge milestone for the AV industry, but even more importantly a signal to the country that CA prioritizes progress over our tragic status quo.

We share the CPUC’s commitment to delivering safer, cleaner and more accessible transportation options, and remain committed to collaborating closely with regulators to push toward this critical goal.

Let’s Cruise!

[Scott Becker @scottbecker]

@cathyarnst @matthewherper @UPMC @KFFHealthNews Fortunately, we have the American legal system. Patients aren't powerless if they are billed above market value for services rendered. Covered by Stat here https://t.co/1mC0fUfiVR

[Scott Becker @scottbecker]

@NikoMcCarty @iGEM Add a furin cut site + GSG before the 2A to reduce extra amino acids on your N terminus and boost cleavage. Also, plasmids may replicate in mammalian cells using ebna-1/oriP or S/MAR (not sv40 ori / 293tt, it's transient). We have seen oriP work and we haven't tried S/MAR.

[Scott Becker @scottbecker]

@FezMannan @IBKR SVB isn't on their list of banks - https://t.co/tnlpMg1sbY

[Scott Becker @scottbecker]

@matthewherper @tiffkhsu @pkafka As a former adtech person now in biotech, I think I can help explain this article for you: getting your information on adtech from NYTimes would be as advisable as getting biotech/pharma info from NYTimes instead of Stat+.

[Scott Becker @scottbecker]

@ATinyGreenCell If you need to add really big inserts Flp/frt recombination has a 50% efficiency for even 10kb inserts if you are ok with scars (the frt sites)

[Scott Becker @scottbecker]

@ATinyGreenCell This lambda red + nuclease technique works well - https://t.co/VrfVIQhb6e . If needed you can boost efficiency using a teta-sacb intermediate step if you are ok with temporary antibiotic resistance genes that are removed later.

[Scott Becker @scottbecker]

@gubbeen1 @WTIBull If they complete bankruptcy proceedings after running out of cash and failing to make bond payments they will need to issue new stock to bond holders (chapter 11) or just sell/hand over their remaining assets to bond holders and shut down (chapter 7).