Seth Cheetham

Cheetham Lab @AIBNatUQ |Director @NationalBiolog2 | ARC Future Fellow | #mRNA drug discovery |

[Seth Cheetham @SethCheetham]

The greatest challenge for #mRNA-LNP therapies is targeting non-liver tissues. To overcome this, we used customisable bispecific antibodies to tether mRNA-LNPs to cell-surface proteins, achieving efficient and selective mRNA delivery in vivo. @BASEmRNA

https://t.co/0nJj8eVsqC

[Seth Cheetham @SethCheetham]

To accelerate #mRNA vaccine and therapy research, I'm excited to share our end-to-end protocol for #mRNA design, synthesis and encapsulation in
@NatureProtocols.

Protocol development by @LauraJLeighton, Natasha Chaudhary and Tim Mercer. @BASEmRNA

https://t.co/lsPOKdmz5H

[Seth Cheetham @SethCheetham]

A huge milestone for personalised #mRNA therapeutics for inherited disease! A baby with an ultra-rare mitochondrial disease was treated at UPenn with an mRNA-encoded gene-corrector. The mRNA was made to treat a single individual in just 7 months!

https://t.co/2K77Rxyx8Y

[Seth Cheetham @SethCheetham]

Crucially, this approach doesn't require a new LNP, it works with FDA-approved formulations. We hope that this approach will enable targeted mRNA therapeutics for diverse diseases. Work led by Bettina Dietmair, James Humphries and Chirs Howard. @BASEmRNA @AIBNatUQ @TRI_info

[Seth Cheetham @SethCheetham]

Systemic mRNA-LNP delivery beyond the liver? Check out our recent paper demonstrating cell-specific mRNA-LNP delivery using PEG- and target cell-specific antibodies. This approach can customised to any target cell-type with off-the-shelf mRNA-LNPs. 1/

https://t.co/MIyfH9vWz3

[Seth Cheetham @SethCheetham]

The technology is programmable and works with other targeting arms including anti-PSMA (highly expressed on prostate cancer cells) bispecifics.

[Seth Cheetham @SethCheetham]

Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc Laura Leighton found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics.

https://t.co/bwdF4EA5UA

[Seth Cheetham @SethCheetham]

Interested in undertaking a #PhD in the transformative field of #mRNA cancer vaccines? I have an earmarked PhD #scholarship available for an outstanding domestic student to join our team at @UQ_News and @BASEmRNA . If this sounds like you, get in touch.

https://t.co/PkBhOHdmpp

[Prof Paul Beavis @paulbeavis4]

Opportunity for a bioinformatician to join the lab @PeterMacRes to help us identify new Immunotherapies. Please reach out for further details. Ad is for a post doc but research assistants considered. 💻 🧬. See link below.

[Seth Cheetham @SethCheetham]

Wow this is super cool! Single-cell resolution imaging of
#mRNA-LNP biodistribution in cleared mouse bodies.

https://t.co/W6v8TkTzuy

[Seth Cheetham @SethCheetham]

Exciting news! @BASEmRNA and Vaxxas have been awarded the $2M USD Biomedical Advanced Research and Development Authority (BARDA) Patch Forward Concept Stage Prize to develop thermostable needle-free mRNA vaccines! @AIBNatUQ

https://t.co/1MCQldUyL1

[Seth Cheetham @SethCheetham]

It was fantastic collaborate with @Fer_NK_nando on this programme to develop CAR-NK therapies for sarcoma with #mRNA tech. These mRNA-enhanced NK cells can eliminate cancer cells in vitro and in vivo. Out now in Clinical and Translational Medicine. @TRI_info @AIBNatUQ @BASEmRNA

[Seth Cheetham @SethCheetham]

Awesome work from @MJMitchell_Lab at UPenn in @Nature identifies novel LNPs that can deliver #mRNA to the placenta. Using the placenta-targeting LNPs to deliver VEGF mRNA improves pre-eclampsia in animal models.

https://t.co/RbDtBF7H1Q

[Seth Cheetham @SethCheetham]

Earlier this year I had the opportunity to present a TEDx talk on the transformative potential of personalised
#mRNA vaccines for cancer. The recording is out now: https://t.co/mmWlJznpKN

@AIBNatUQ @BASEmRNA @UQ_News

[Seth Cheetham @SethCheetham]

@BASEmRNA Work led by Helen Gunter @Mercerlab1, @AIBNatUQ @TRI_info @UQ_News

Try it out here:
https://t.co/LMl2WpqGHe

[Seth Cheetham @SethCheetham]

There are more ways to design an mRNA than atoms in the universe, so how do you choose the best one? Our new @BASEmRNA software, mRNArchitect enables you to tune expression, stability, reactogenicity and synthesisability to design more potent #mRNA drugs

https://t.co/ZzJNXSYv2J

[Seth Cheetham @SethCheetham]

@andreabrandlab Congratulations all. Very cool to see a resolution to this longstanding mystery.