SextonLab

Discovering deeper links between drugs and diseases through high content analysis and machine learning. Located in Michigan Medicine.

[SextonLab @SextonLabUM]

Congrats to our own @jesse_wotring in his most recent publication: validating lactoferrin’s anti-SARS-CoV-2 activity!

https://t.co/1zLYFE2n4W

[SextonLab @SextonLabUM]

@biorxivpreprint This project was not possible without the hard work and collaboration between @Charles_J_Zhang @momeara @CapelingMeghan @DayFerrerTorres @TheSpenceLab @RobertFontanaMD @jonnysexton and others

[SextonLab @SextonLabUM]

Drug-induced liver injury has always been a burden on drug development, calling for better in vitro liver models. In this study, we combined a protocol for developing human liver organoids from iPSCs and a microfluidic “chip” system towards that goal.

[bioRxiv @biorxivpreprint]

A Multi-Omics Human Liver Organoid Screening Platform for DILI Risk Prediction https://t.co/nHiGtomiXH #bioRxiv

[SextonLab @SextonLabUM]

US Study Shows 'Several Drug Contenders' Kill SARS-CoV2 Infection in Cells https://t.co/OGHW7JyHtt

[SextonLab @SextonLabUM]

@jesse_wotring @Charles_J_Zhang @MedChemMcCarty @tristanfrum @teresa_omeara

[SextonLab @SextonLabUM]

We are happy to announce our SARS-CoV-2 drug repurposing screen has just been published in PNAS! This was a massive team effort that would not be possible without many, including @ChristianeWobus @TheSpenceLab @ArulChinnaiyan @momeara

https://t.co/fPRUm3p0lx

[SextonLab @SextonLabUM]

Exciting to share our work from a strong collaboration! Such great work by @DayFerrerTorres that we are thankful to be a part of.

[Jason Spence @TheSpenceLab]

It’s a super fun and exciting day in the @TheSpenceLab!

An entirely new research direction for the lab studying the adult human esophagus led by @DayFerrerTorres. Collaboration with many colleagues including @SextonLabUM @Charles_J_Zhang https://t.co/0BQzEJ6kza @MichaelDame1

[SextonLab @SextonLabUM]

Congrats to our three grad students, @Charles_J_Zhang, @MedChemMcCarty, and @jesse_wotring for flawlessly advancing into candidacy! Big things to come!

[SextonLab @SextonLabUM]

As #COVID19 manifests differently in different tissues we study their effects on a wide variety of cell lines. Cardiomyocytes are particularly interesting because you can watch them beat! Great work from Carla, @psychsiren!

[Charles Jian Zhang @Charles_J_Zhang]

Needed a physiological lung model, so I made one in an “organ-on-chip” system grown with @tristanfrum’s airway basal cells. Air flow and stretch applied to mimic breathing results in mucosal and ciliated cells. Hope to validate this for #COVID19 and other diseases! @SextonLabUM

[Cayman Chemical @CaymanChemical]

@jesse_wotring @SextonLabUM Thank you for doing this important research, and we're thrilled to be a part of it!

[Jesse Wotring @jesse_wotring]

@CaymanChemical Always making research possible! We used your FDA approved compound library to find drugs that can help fight SARS-CoV-2! Thank you for your help from a former Cayman Chemical intern under Holly Pierzynski and Nathan Layle! @SextonLabUM https://t.co/SSPoFXXrNl

[SextonLab @SextonLabUM]

@momeara gives a great breakdown here of our results!

[Matthew O’Meara @momeara]

Thrilled to share UMich SARS-CoV-2 drug screening results! @SextonLabUM @DrugRepurposing, @jesse_wotring, Carmen Mirabelli, @Charles_J_Zhang, @MedChemMcCarty, @teresa_omeara, @tristanfrum, Samuel handleman, @momeara @jonnysexton @UM_MICHR @thespencelab. https://t.co/o36bZrsJQS

[SextonLab @SextonLabUM]

We identify 15 FDA approved drugs and lactoferrin with possibility of treating SARS-CoV-2.

[bioRxiv @biorxivpreprint]

Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 https://t.co/FcPQamB5tD #bioRxiv

[jonnysexton @jonnysexton]

Our Covid19 drug repurposing screen found 15 FDA-approved drugs and the dietary supplement Lactoferrin have strong antiviral effects in vitro: https://t.co/AcyTd405al

[SextonLab @SextonLabUM]

Tune in to this recent Michigan Minds podcast, where Jonathan Sexton describes our ongoing project in addressing COVID-19.
https://t.co/3Riae7VCSD

[jonnysexton @jonnysexton]

ShoutOut to UM Center for Drug Repurposing in Scientific American's new article on drug repurposing: https://t.co/f2Mt7Nokg4

[jonnysexton @jonnysexton]

Check out our collaborative study with Dr. Rishel Vohnoutka where we used @CellProfiler to quantitate cytoskeletal structure using radial distribution of intensities! On cover of MBoC - https://t.co/imrsAl6CNR

[University of Michigan Drug Repurposing @DrugRepurposing]

@jonnysexton introducing the new MICHR Drug Repurposing center, designed to find new usage in old drugs! https://t.co/Np6AVBjaD0

[University of Michigan Drug Repurposing @DrugRepurposing]

Hello world! Tomorrow marks the beginning of U of M Drug Repurposing. Please join us at our Town Hall where we will be introducing our services. Details: https://t.co/OmTY5zZUb2