Shadi

pharmacist⚕️

[Foster Drug Info⚕️ @FosterDrugInfo]

♥️#Hypertension Treatment:
🤰Patients who may become #Pregnant

☝🏽Monotherapy:
💊#CCBs
✔️Preferred: #Nifedipine
🔘Alternative: #Amlodipine

✌🏽Combination therapy:
💊a CCB➕
☑️a #Thiazide-like Diuretic
OR
☑️a certain #Beta_Blocker:
🔘#Labetalol
🔘#Carvedilol
🔘#Metoprolol

[Shadi @Shadihaddadi]

Combining these drugs is associated with adverse cardiovascular and kidney events.

[Foster Drug Info⚕️ @FosterDrugInfo]

♥️#Blood_Pressure Management:
🚫Drug combinations to avoid

❌#ACE_inhibitor ➕ #ARB ⚠️
❌#Direct_Renin_inhibitor (#Aliskiren) ➕ ACE inhibitor or ARB ⚠️
❌#Beta_Blocker ➕ #Diltiazem or #Verapamil ⚠️
❌Alpha-1 Adrenergic Blocker ➕ Clonidine ⚠️
❌Beta-Blocker ➕ #Clonidine ⚠️

[Foster Drug Info⚕️ @FosterDrugInfo]

🚺#Bacterial_Vaginosis: Male Sex Partner Treatment to Prevent Recurrence

⏳A 7-day #Antibiotic treatment course.

💊Oral #Metronidazole 400 or 500mg, BID
➕
🧴Topical 2% #Clindamycin applied to the penile skin, BID

✅Male treatment should coincide with female partner treatment.

[Foster Drug Info⚕️ @FosterDrugInfo]

♥️#Hypertensive_Urgency: #Sublingual vs. #Oral Captopril

❌SL #Captopril 25mg produces a greater reduction in #Systolic_Blood_Pressure.

✅Oral captopril is associated with a superior decrease in #Mean_Arterial_Pressure, the primary therapeutic goal in #Emergency_Hypertension.

[Foster Drug Info⚕️ @FosterDrugInfo]

💢Main reasons for diluting the #Corticosteroids with #Lidocaine before intra-articular injection:

✅Instant #anesthetic relief confirms accurate injection placement.
✅Lowers risk of steroid-induced tissue atrophy.
✅ Reduces crystal-related irritation and post-injection flare.

[Foster Drug Info⚕️ @FosterDrugInfo]

♥️#Hypertensive_Urgency: Management

😴#Antihypertensive drugs may be given to patients if resting in a quiet room for 30mins is not effective.

📉The shorter-term goal is to reduce the BP to ≤160/100.

‼️#Mean_Arterial_Pressure should not be lowered >30% over the first hours .

[Shadi @Shadihaddadi]

Although routine monitoring of creatine kinase (CK) levels is not recommended in the absence of significant myalgia, CK elevations occur in approximately 15–50% of patients with isotretinoin-induced muscle pain.

[Foster Drug Info⚕️ @FosterDrugInfo]

💊#ISOTRETINOIN: Lab Monitoring

⤴️#Hypertriglyceridemia:
✓ 300–500 mg/dL:
Lifestyle management
✽ 500–800 mg/dL:
Consider dose reduction or lipid therapy
✗ >800 mg/dL:
Discontinue

⤴️#Liver_Enzyme_Elevations:
✗ Stop Isotretinoin if levels >3× normal.

🤰#Pregnancy testing

[Shadi @Shadihaddadi]

Progestin-only contraceptives — particularly low-dose oral pills containing androgenic progestins (such as norethindrone or desogestrel) — are not effective for acne treatment and may even worsen acne vulgaris.

[Foster Drug Info⚕️ @FosterDrugInfo]

💢#Acne_Vulgaris Management: COCs

✅FDA Approved:
EE 20/30/35 +#Norethindrone 1mg
EE 35 +#Norgestimate 180/215/250mcg
EE 20 +#Drospirenone 3mg

❇️Others (Anti-Androgens):
EE 30 + #Drospirenone 3mg
EE 30 + #Dienogest 2mg
EE 30 + #Chlormadinone 2mg
EE 35 + #Cyproterone_Acetate 2mg

[Shadi @Shadihaddadi]

Beta blockers have various noncardiac effects, with significant impacts on lung function, energy levels, and sexual performance.

[Foster Drug Info⚕️ @FosterDrugInfo]

💢#BETA_BLOCKADE: Adverse noncardiac effects

🔺#Airways_Resistance
🔺#Peripheral_artery disease
���#Facilitation of #Hypoglycemia
🔺#Hyperkalemia
🔺#Depression
🔺#Fatigue
🔺#Sexual_dysfunction
🔺#Lipid_metabolism alteration
🔺#Weight_gain

🔗https://t.co/VXndtkl51Z
#Betablocker

[Foster Drug Info⚕️ @FosterDrugInfo]

🥶#Pica: #Pagophagia

🩸Various forms of may be a clinical manifestation of #Iron_Deficiency, with or without #Anemia.

🧊Craving #ice is particularly common and is often associated with an #iron deficiency.

⚠️It may be present in children with #NonAnemic_Iron_Deficiency.

[Grok @grok]

The association between pagophagia and iron deficiency is very strong. Studies show pagophagia is common in iron-deficient individuals, with 11% of iron-depleted blood donors and 34% of men with iron-deficiency anemia reporting it. In pregnant women with pica, 76% had pagophagia. Treating iron deficiency often resolves the craving, as seen in cases where symptoms stopped within weeks of supplementation. This suggests a causal link, recognized across diverse groups, making pagophagia a key indicator of iron deficiency. https://t.co/pqlzSn9qEN

[Shadi @Shadihaddadi]

@FosterDrugInfo Hey @grok how strong is this association?

[Shadi @Shadihaddadi]

Daily dosing can decrease absorption; however, it may improve adherence for some individuals.

[Foster Drug Info⚕️ @FosterDrugInfo]

🩸#Iron_Deficiency: #Older_Adults

⚠️Older adults with iron deficiency #Anemia should take no more than 1 low-dose oral #Iron tablet daily.

✅Low-dose #Oral_Iron_Therapy (<50mg elemental iron/day) is as effective and has fewer #Adverse_Effects than high-dose therapy (150mg/day).

[Shadi @Shadihaddadi]

Pharmacotherapy for binge eating disorder is less effective than psychotherapy or self-help.

[Foster Drug Info⚕️ @FosterDrugInfo]

🫃🏻#Binge_Eating_Disorder: #Topiramate

💊 Except Topiramate, #Pharmacotherapy does NOT reduce #binge eating more than #Cognitive_Behavioral_Therapy (#CBT) alone.

✅Dosing:
🔸Start with 25mg/day
🔺Increase the dose in increments of 25-100 mg at intervals ≥1 week
up to 400mg/day.

[Shadi @Shadihaddadi]

Activities should be adjusted to prevent mosquito bites. This may include staying indoors during dawn and dusk and avoiding wetlands.

[Foster Drug Info⚕️ @FosterDrugInfo]

🦟#Mosquito #Bites: #Avoidance

🙌Applied to Skin (even #Children >2 months):
✔️#DEET (N,N-diethyl-3-methylbenzamide)
✔️#Picaridin (up to 10 hours)

⛺Applied to fabrics (not skin):
✔️#Permethrin

⏰Short-acting agents:
✔️#Citronella (20 minutes)
✔️#Lemon_Eucalyptus_Oil (2 hours)

[Shadi @Shadihaddadi]

Activities should be adjusted to prevent mosquito bites. This may include staying indoors during dawn and dusk and avoiding wetlands.

[Shadi @Shadihaddadi]

Treatment for pregnant individuals primarily aims to relieve symptoms; vaginal candidiasis is not linked to adverse pregnancy outcomes.

[Foster Drug Info⚕️ @FosterDrugInfo]

🤰#Vulvovaginal #candidiasis: Treatment in #Pregnancy

✅Vaginal creams for 7 nights
🔹#Clotrimazole 1%
🔹#Miconazole 2%

✅Vaginal suppository for 14 nights
🔸#Nystatin 100,000 IU

❌Avoid:
🔻#Fluconazole
🔻#Oteseconazole
🔻#Ibrexafungerp
🔻#Terconazole
🔻#Vaginal #boric_acid

[Shadi @Shadihaddadi]

These findings indicate that seizures may be an adverse effect of first-generation antihistamines in susceptible children, reinforcing existing recommendations to avoid their use in the pediatric population.

[Foster Drug Info⚕️ @FosterDrugInfo]

⚠️1st-Gen #Antihistamines: #Seizures

🚸1st-Gen #Antihistamine use was associated with a 22.0% higher #Seizure risk in children.

🚼Analyses showed children aged 6 to 24 months who were prescribed 1st-gen antihistamines had a #higher_risk (AOR=1.49).

🔗https://t.co/UjpDI7miIX

[Shadi @Shadihaddadi]

This aligns with studies showing that most women regain fertility quickly after stopping COCs. Interesting to see how the return to ovulation varies among different contraceptive methods!

[Foster Drug Info⚕️ @FosterDrugInfo]

💊#Combination_Oral_Contraceptives (#COCs): #Fertility Return

🩸A small observational study found that 97% of women resumed #menstruation within 90days (median: 32days)

🤰A larger cohort study showed 79.4% conceived within a year—similar to the general population
#Birth_Control

[Shadi @Shadihaddadi]

As individuals age, their body's response to medications (pharmacodynamics) can change, making some drugs more potent or less effective.

[Foster Drug Info⚕️ @FosterDrugInfo]

👵🏼#Pharmacodynamics: Influence of #Aging

📉Overview of pharmacodynamic changes that occur with #Ageing, highlighting their impact on #drug_action and the corresponding adjustments needed in dosing to ensure #efficacy and safety in #geriatric_patients.

🔗https://t.co/j9r923NnZ3