Hunter Shain

Associate Professor, Dermatology, UCSF. part of HTAN. Melanoma, skin cancer, single-cell, DNA/RNA-seq, spatial transcriptomics, cancer, dermatology, pathology

[Hunter Shain @ShainLab]

Major preprint from our group is out. Looking for feedback. We built the largest molecular atlas of cutaneous squamous cell carcinoma (cSCC) to date linking somatic mutations and gene expression patterns to metastatic outcome. A Thread 🧵

[Adam Feuerstein ✡️ @adamfeuerstein]

Still waiting for @VPrasadMDMPH to to sit down for a real interview or podcast where the host(s) don't kiss his ass with softball questions.

[Hunter Shain @ShainLab]

Why do we still have study section chairs in the era of AI?

[Hunter Shain @ShainLab]

A recent preprint documents an uptick in citations to a handful of journals despite no increases in other statistics associated with real readership. Established brands are not guilty. https://t.co/kxKJXv6NTt

[Hunter Shain @ShainLab]

I'm being asked to review papers at journals I have never heard of, and when I google these journals, they have insanely high impact factors. Apparently, I am not the only one to notice this.

[Hunter Shain @ShainLab]

To be sure, it is a real time change, and the Rams were dumb to land the day before the game, but the 49ers season is not shot. They have 9 days to shift their clock 7 hours. I think they'll be fine

[Hunter Shain @ShainLab]

It funny to hear about the 17 hour time different between SF and Melbourne. It is not possible to have have more than a 12 hour time difference, unless you think NY and Chicago are 23 hours apart.

[Hunter Shain @ShainLab]

I wondered the same thing. No issues with the punishments doled out to the franchise and agent, but how did Leonard get off scot-free? He just thought someone wanted to pay him 10 mil for doing nothing?

[Nate Silver @NateSilver538]

So Kawhi “pocketed tens of millions of dollars” but “did not have any knowledge” of the cap circumvention? C'mon, Shams. ESPN just got burned big time and has to take a moment to reflect here.

[Hunter Shain @ShainLab]

@ProfGLongMIA Congrats!

[Hunter Shain @ShainLab]

@andrewlji Congrats! Well deserved!

[Hunter Shain @ShainLab]

@drugmonkeyblog I'm with Jason on this. Preprints changed the game.

[Hunter Shain @ShainLab]

So many squirrels were tortured in the 3 hours of REM sleep today. And if you were wondering, mastiffs have crazy high heart rate variabilities...

[Hunter Shain @ShainLab]

My 100lb dog and I are tag teaming the @eightsleep app. Got an extra daytime sleep session in from 8am to 5pm, bringing our surplus sleep to nearly 25 hrs!

[Hunter Shain @ShainLab]

Most GWAS are meta-analyses that combine new cohorts with older studies, many of which relied on array-based genotyping. At what point is it better to start over with sequencing-based genotypes? More cases/controls is great, but I wonder when WGS resolution outweighs sample size

[Hunter Shain @ShainLab]

Spent more time than I care to admit today today trying to upload a table during a routine manuscript submission 🤦‍♂️. Am I right @_SharmaHarsh

[Hunter Shain @ShainLab]

One of the great mysteries of academic publishing is why journals insist on taking large Excel tables, whicha re perfectly functional, searchable, and readable, and converting them into 87-page PDFs that are none of those things.

[Hunter Shain @ShainLab]

@mbeisen Does Berkeley have an Enterprise plan that runs out of tokens after 2 questions in Pro mode? Thats the experience at your sister UC across the bay (UCSF)

[Hunter Shain @ShainLab]

Public-service warning: @BayAreaClipper made over $200 in unauthorized “parking” charges to my account. Still no refund or explanation despite 4 phone calls and many more emails.

[Hunter Shain @ShainLab]

@CalebLareau In my experience, a lot of people develop phylogeny software on optimal samples (with specific, sensitive mutation calls and no copy number alterations) and then apply it to suboptimal samples. Thanks for highlighting the importance of these factors.

[Hunter Shain @ShainLab]

I have not seen the data, but investors have. All signs suggest that the mRNA vaccine works in a phase III clinical trial.

[Hunter Shain @ShainLab]

That dreaded email 48 hours before your grant is due to your clinician colleague... "Uhmn, can you create a ScienCV account and import everything from your old biosketch into this new format, and learn some basic html so you can bold/italicize key accomplishments"

[Hunter Shain @ShainLab]

Switching to the NIH common form was annoying for me personally, but I got over it. However, now I am having to ask every collaborator to deal with this on all my grants.