Shamchal Bakavayev

Postdoctoral fellow at @NIH || Interested in gene editing technologies

[Shamchal Bakavayev @ShamchalB]

@paperperday Very cool to see genome editing moving from changing a few bases to installing entire genetic programs

[Shamchal Bakavayev @ShamchalB]

I’m very grateful to BrightFocus Foundation, Michael Ward, and everyone in our lab for their support. I’m excited to continue developing this project and see where it takes us!

[Shamchal Bakavayev @ShamchalB]

Excited to share that I’ve been awarded a BrightFocus Foundation Alzheimer’s Disease Research Grant!

I’ll be using prime editing and high-throughput imaging to study how Alzheimer’s-associated mutations affect protein localization in human neurons and glia.

[Shamchal Bakavayev @ShamchalB]

Read more about the project:
https://t.co/ytoeugfd9e

[David R. Liu @davidrliu]

Today in @natBME we report an in vivo base editing strategy that corrects a common disease-causing mutation and rescues pathology in a mouse model of Zellweger spectrum disorder (ZSD) and restore peroxisomal function in patient derived cells. This work highlights the promise of precision genome editing for treating peroxisomal biogenesis disorders.
1/13

[M W @Michael_E_Ward_]

Excited to share a pre-print from a collaboration between my lab at NIH, Len Petrucelli's lab at University of Miami, and Shyamal Mosalaganti's lab at University of Michigan.

[Nature Biotechnology @NatureBiotech]

Precise, minimally evolved adenine base editors generated through mutation reversion analysis https://t.co/cWSs7Q8srF

[Nature Biotechnology @NatureBiotech]

Immune-evasive cssDNA donors combined with recombinases facilitate kilobase-scale insertion of custom genetic cargos in human cells and mice. #NBThighlight https://t.co/opGmsUTTCp

[Nature Biotechnology @NatureBiotech]

Engineered base editors with reduced bystander editing through directed evolution - @rmperrotta @geochurch https://t.co/MMstqYHDfm

[David R. Liu @davidrliu]

Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases.
(1/15)
https://t.co/zs0qu5bhXx

[Vikash P. Chauhan @vikpc]

Genome editors like prime editors can rewrite the genetic code – but sometimes they incorporate undesired errors. Today in @Nature, we report how we engineered prime editors with strikingly low errors.
https://t.co/6TBqcHCaVL
#GenomeEditing #CRISPR #PrimeEditing #genetherapy

[Nature Biotechnology @NatureBiotech]

High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase https://t.co/jSUio33Uqq

[David R. Liu @davidrliu]

In @NatureGenet we report that base editing of trinucleotide repeats (TNRs) reduces somatic repeat expansions in Huntington’s disease (HD) and Friedreich’s ataxia (FRDA)—in patient-derived cells and in vivo—a collaboration with the Mouro Pinto lab.
https://t.co/J6MhwEAgoB
1/14

[HHMI @hhmi_science]

A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the @ChildrensPhila who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI Investigator @davidrliu and his lab at @Harvard University in 2016.

Earlier this year, Liu received the @brkthroughprize for developing both base editing and prime editing. These gene-editing technologies enable the correction or replacement of virtually any genetic mutation, including those that cause countless human genetic diseases.

Read more about Liu's work here: https://t.co/NlE25O7wJR

[Ophir Shalem @ophirshalem]

Excited to to see our collaboration with @GMBurslem lab published today! This is part of our ongoing long term goal of achieving scalable non-disruptive and direct imaging and perturbation of the endogenous proteome
https://t.co/HJX3JHvBIY

[Shamchal Bakavayev @ShamchalB]

@ophirshalem @MolecularCell @stephsansbury @YSereb Beautiful work!

[Ophir Shalem @ophirshalem]

Check out our paper, now extensively revised and published in @MolecularCell! This has been a real tour de force led by @stephsansbury and @YSereb and we are very excited about the findings and future potential of this approach
https://t.co/XLpJxmzGvh

[nature @Nature]

If you want to understand how cells function, you have to work out what proteins interact with — and where

https://t.co/XXYcxS1LVm

[Manuel Leonetti @LeonettiManuel]

So excited to start the year w/ our new paper @CellCellPress! #proteomics spatial map of human cells + dynamics using #organelle IP at scale. 🙌 to amazing teamwork @czbiohub and beyond. Check out portal https://t.co/Gb1TvlKcCH and paper https://t.co/YskVRBUqZi. 1/n

[Nature Biotechnology @NatureBiotech]

Internal cap-initiated translation for efficient protein production from circular mRNA - @Gaussian55You https://t.co/LFlFfj1WT1