Shang-Chuen Wu

Glycobiology researcher

[Science Translational Medicine @ScienceTM]

The complement arm of immunity is a major driver of acute chest syndrome in #SickleCellDisease, shows new work involving mice and patient samples that also reveals targeting C5 can alleviate lung damage in vivo. @Stowell_lab @ATLPedsHemOnc https://t.co/yqQbym9MT0

[Sean Stowell lab @Stowell_lab]

I don’t post very often, but I couldn’t help sharing the experience that led to this paper, published earlier this week. (https://t.co/X1LOsx0VzX)

During my first year of residency, I was involved in the care of a patient with sickle cell disease who experienced a severe transfusion complication. Despite heroic efforts by many involved, he eventually succumbed. His case was unfortunately not unique. Other patients with sickle cell disease suffered similar fatal transfusion complications. These experiences completely changed the trajectory of my career. It was during this time that I was incredibly fortunate to meet Satheesh Chonat, one of the most impressive physician-scientists I have ever had the chance to work with and someone who has become a lifelong friend and colleague. Building on a critical research infrastructure established by Solomon Ofori-Acquah, Olufolake Adisa, and Ross Fasano, Satheesh and I, along with many others, set out to understand the underlying factors that may contribute to some of the most severe complications patients with sickle cell disease experience. That was over 10 years ago. The manuscript below is a product of work that started then, made possible by the participation of many patients and investigators. While many more studies are certainly needed, we hope these data contribute to the ongoing incredible work by many of our wonderful colleagues, including Lubka Roumenina, Pablo Bartolucci, France Pirenne, Solomon Ofori-Acquah, Greg Vercellotti, Karina Yazdanbakhsh, Robert Brodsky, among others, examining the role of complement in the pathogenesis of sickle cell disease. Perhaps these collective studies, and others like them, will identify better ways to manage complications that patients with sickle cell disease unfortunately experience.
#ASH_hematology
#AABB
#ATLPedsHemOnc
Mass General Brigham highlight: https://t.co/RE8rKYGYWa

[Shang-Chuen Wu @Shang_Chuen_Wu]

@Stowell_lab Great job RJ

[Sean Stowell lab @Stowell_lab]

Happy #NationalPostdocAppreciationWeek! 🎉 Postdocs are the backbone of groundbreaking research, pushing the frontiers of science and knowledge every day. Thank you for your dedication, resilience, and passion! 🌟 #PostdocPride #ResearchHeroes

[Sean Stowell lab @Stowell_lab]

Congratulations to @Shang_Chuen_Wu, @Justin_Jan_4928, and other members of our lab for their recent publication on the dimeric nature of galectin-4! #galectin #glycobiology #Immunology
https://t.co/nRH16gnOMd

[Shang-Chuen Wu @Shang_Chuen_Wu]

@Stowell_lab @BYU @EmoryUniversity @BU_Tweets @UCSanDiego @Northeastern We’re so lucky to have you guys in the lab 😊

[Sean Stowell lab @Stowell_lab]

This summer, we hosted students from @BYU @EmoryUniversity @BU_Tweets @UCSanDiego and co-ops from @Northeastern who all gained experience in glycobiology and transfusion medicine. We will miss them and wish them luck as they begin their fall semesters!

[Sean Stowell lab @Stowell_lab]

In honor of #SickleCellAwarenessMonth we are spotlighting this review that discusses the difficulty surrounding alloimmunization during patient treatment. #bloodtransfusion #gettoknowsicklecell #sicklecell @BloodHealthEd https://t.co/Yer4i94pl7

[Sean Stowell lab @Stowell_lab]

Did you know that the severity of your #covid19 infection could be affected by your blood type? As we are seeing spikes in COVID-19 cases, it is relevant to bring up this article published with Dr. Connie M. Arthur and Dr. Richard D. Cummings.
https://t.co/KNkV0HQOiv

[SFGlycobiology @SFGlycobiology]

Awesome time at the trainee mentoring session today! Thanks for attending #SFG2023 @BoyceLab @DocGatorDawg1 @OVSlab_OGlcNAc

[Sean Stowell lab @Stowell_lab]

It's great to attend the 2023 SFG meeting in Hawaii, and congratulations to @DoMorais_ and @Shang_Chuen_Wu on receiving the SFG travel award.

[Sean Stowell lab @Stowell_lab]

Congratulations to Dr. Ryan Philip Jajosky on getting his paper published. Hopefully, our proposed treatment will be utilized to help malaria patients.
https://t.co/ycr93SDO3L

[Shang-Chuen Wu @Shang_Chuen_Wu]

@Stowell_lab @DoMorais_ Congratulations!

[Sean Stowell lab @Stowell_lab]

Congratulations to Rebecca Hale and @DoMorais_ Dominique Morais for their excellent contribution in reviewing glycosylation in clinical allergy and immunology. https://t.co/fP6YI006dd

[Sean Stowell lab @Stowell_lab]

It was great to visit @glyco26 held at Academia Sinica in Taiwan, which is amazing. Congratulations to @Shang_Chuen_Wu Peter for receiving the Glyco26 Poster Awards and delivering a wonderful oral presentation.

[Sean Stowell lab @Stowell_lab]

Congrats to Mischa!! https://t.co/fo8ur91mjV

[Glyco26 @glyco26]

Flags Up ! #Glyco26

Photo taken in front of the Institute of Biological Chemistry, where the Galectins satellite meeting will kick off today.

[SFGlycobiology @SFGlycobiology]

🚨 2023 SFG Awardees 🏆!!
Glycobiology Significant Achievement Award: Dr. Matthew Macauley @MatthewMacaule4(University of Alberta @UAlberta) and Dr. Sean Stowell @Stowell_lab (Harvard Medical School @HMSCfG)
Congratulations!!

[Sean Stowell lab @Stowell_lab]

Acknowledging and thanking my lab members and collaborators for their invaluable contributions.
https://t.co/cXuc8gW7rd

[Sean Stowell lab @Stowell_lab]

Congratulations to Patricia E. Zerra, MD, and Shang-Chuen Wu, PhD, on winning the 2023 AABB Foundation Early-Career Scientific Research Grant! 🌟Their exceptional work in scientific research has earned them this prestigious recognition.