Shahrzad Shoushtar

Scientist Loading …

[Martin Picard @MitoPsychoBio]

The term mitochondrial dysfunction is often misnomer

Something that looks “dysfunctional” with a single approach can end up being an adaptive recalibration when seen more holistically with multiple measures

Excellent paper below by @ChrisPerryMito

[Shahrzad Shoushtar @SharShoush]

New review from our lab ☺️

[Christopher Perry PhD @ChrisPerryMito]

When is a change in mitochondrial bioenergetics reflective of 'mitochondrial dysfunction' vs 'intentional reprogramming'?

Here we present traditional vs alternative interpretations of mitochondrial responses to muscle disuse.

https://t.co/mvtMxAGnp3

[Christopher Perry PhD @ChrisPerryMito]

We're excited to see each of our 3 preprints last week pass 100 downloads. Please send feedback about this work on preclinical therapy development in Duchenne muscular dystrophy and ovarian cancer cachexia
https://t.co/SBr7WjUaKB
https://t.co/4x03UA7rnt
https://t.co/A1Z80Oyh8r

[Christopher Perry PhD @ChrisPerryMito]

Our 3rd new manuscript this week: @DelfinisLuca found a mitochondrial-targeted compound partially prevents muscle weakness without preventing atrophy in ovarian cancer. This opens a new direction for therapies targeting muscle ‘quality’. https://t.co/tavvytrjCh

[Christopher Perry PhD @ChrisPerryMito]

We just uploaded our next preprint on cancer-cachexia.

Shahrzad Khajehzadehshoushtar discovered 'the mitochondrial-targeted antioxidant SkQ1 prevents mitochondrial-linked apoptosis but not necroptosis or skeletal muscle atrophy in ovarian cancer'

...why is apoptosis active?

[Christopher Perry PhD @ChrisPerryMito]

NEW preprint: Shivam Gandhi in our lab shows cardiac fibrosis in a young mouse model of Duchenne muscular dystrophy occurs in 2 of 4 chambers. Why not all 4?
Remarkably, this fibrosis is completely prevented by a novel adiponectin receptor agonist ALY688.
https://t.co/GUNMqv8XSm

[Shahrzad Shoushtar @SharShoush]

Grateful to be part of this team and to have such amazing teachers the past 2 years 😁

[Christopher Perry PhD @ChrisPerryMito]

Seeing these two convocate at the same time was a special experience for me. Shahrzad Khajehzadehshoushtar @shardarabi_, MSc, and Luca Delfinis @DelfinisLuca, PhD. This duo poured their passion into a huge shared project on ovarian cancer-induced cachexia. Onward and upwards!

[Shahrzad Shoushtar @SharShoush]

@AJosseKin @ChrisPerryMito Thank you!!

[Christopher Perry PhD @ChrisPerryMito]

Congrats to Shahrzad Khajehzadehshoushtar @SharShoush for an outstanding MSc defence! Shar is nominated for a thesis prize for a carefully crafted document, voluminous work, + high-level discussion

Watch for Shar's publication on mitochondrial therapy in ovarian cancer cachexia

[Georg R. Zoidl @RZoidl]

Congratulations Shahrzad for passing the MSc exam with flying colours. We enjoyed your inquisitive mind and commitment to research at the highest level. It was a pleasure to serve as the external examiner along side my dear colleague and supervisor Chris and our Chair Arthur