Shijun Deng

Postdoctoral Fellow at Harvard University

[Shijun Deng @ShijunDeng]

Excited to share our paper on how NFE2L1 senses cholesterol overload in the ER and controls VLDL secretion to protect the liver from MASH. Thanks to @jclinicalinvest for the highlights and Dr. Zang and Dr. Li for the great commentary.
https://t.co/PJrpunCJdn
#MASH #LiverDisease

[Shijun Deng @ShijunDeng]

@jclinicalinvest @UTSA Grateful for the great commentary!

[Journal of Clinical Investigation @jclinicalinvest]

Sunday Spotlight💫 : Targeting hepatic cholesterol sensing to tackle metabolic dysfunction–associated steatohepatitis: https://t.co/wdNCQidwX1

Mengwei Zang and Yu Li @UTSA provide a commentary on Deng et al. https://t.co/UCCAqyhSr1
#MASH #LiverDisease

[Shijun Deng @ShijunDeng]

@jclinicalinvest @harvardmed Thanks for featuring our work!

[Journal of Clinical Investigation @jclinicalinvest]

A highlight💫 from earlier this week: How does the ER cope with cholesterol overload?
https://t.co/rpTOQGH7on
Here, Gökhan S. Hotamışlıgil & team @harvardmed identify the NFE2L1/INSIG1 axis that regulates an ER-nuclear transcription factor important to lipid biosynthesis and VLDL secretion. The protein partnership helps prevent cholesterol buildup and liver damage, revealing a potential target for treating fatty liver disease and related metabolic disorders.

The image shows COS7 cells expressing NFE2L1 N term deletion construct; labeled for HA (NFE2L1, red), the ER marker KDEL (blue), and Hoechst nuclear dye.
#MASH #LiverDisease

[Shijun Deng @ShijunDeng]

@EbruErbayMDPhD Congratulations Ebru, very well deserved!

[Shijun Deng @ShijunDeng]

@jasonhyang @ma_lab_cgidr Congratulations!

[Gökhan Hotamışlıgil @ghotamis]

Congratulations to Dr. Renata Goncalves @RenataG81952725 @gshlab for being recognized by Boston Area Nutrition Obesity Research Center Outstanding Manuscript Award @BostonAreaNORC for her studies on discovering a CoQ metabolism defect leading to reverse electron transport and site-specific ROS production in mitochondria as a mechanism disrupting hepatic metabolism 🧿👏
https://t.co/K46thGNkqb

[Shijun Deng @ShijunDeng]

@dchloechung Congratulations

[Dr. Mehmet Zeynel Cilek @mzcilek]

@gshlab @gparlakgul @ghotamis Congratulations @ghotamis hocam!

[nature @Nature]

Nature research paper: CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis

https://t.co/fXc3w9vTeP

[Hotamışlıgil Lab @gshlab]

The Hotamışligil Lab is hiring! We are looking for an Assistant Director of Strategic Alliances. More info here: https://t.co/JkHry4CsKX

[Shijun Deng @ShijunDeng]

@apsarruda @gparlakgul Congratulations Gunes and Alessandra!

[Shijun Deng @ShijunDeng]

@gparlakgul @apsarruda @BerkeleyMetBio Congratulations Ana🎉

[Shijun Deng @ShijunDeng]

@rushika_perera @RosaMenjivarPhD @kioneillphd @GillesRademaker @graceah9 @marineberquez @YangYan55648779 Congratulations!

[Shijun Deng @ShijunDeng]

Thrilled by #NLASessions ! Foundation of Lipidology course brilliantly bridged basic science to clinical practice. 🔑 takeaways: real-world LLT challenges and novel therapeutic targets. Thank you to the organizers & faculty! Excited to apply these perspectives to my research!

[Gökhan Hotamışlıgil @ghotamis]

Excited to share our latest paper led by Renata Goncalves @RenataG81952725: CoQ imbalance drives reverse electron transport to disrupt liver metabolism.

https://t.co/svgsVGKCfd

We uncover how altered CoQ redox balance triggers RET and rewires hepatic metabolism to offer critical insights into a decades old question. Meticulously mapping each one of the 11 sites of the mitochondrial electron transport chain in the liver showed site IQ as the sole source of excess mitochondrial ROS, produced via reverse electron transport. This defect is driven by CoQ imbalance in obesity, disrupts glucose metabolism.

These findings may have implications for many diseases and open up new treatment possibilities where broad antioxidants have failed to generate therapeutic benefit. Our findings may also offer a potential mechanism and solution for the increased diabetes risk seen in a small fraction of statin users.

Huge congratulations to Renata Goncalves @RenataG81952725 for leading this work and for her immense dedication and patience to bring it to a conclusion. Congratulations to all contributors from the @hotamisligil lab and our amazing collaborators Isabel Graupera @igraupe and Shawn Burgess @Isotopomer

Curious? The 93-page-long peer review file is full of useful information and insightful discussions.

[Shijun Deng @ShijunDeng]

@rushika_perera @Nature @GillesRademaker Congratulations!

[Shijun Deng @ShijunDeng]

@realTonyHui @yuanbogeneral Congratulations!

[Shijun Deng @ShijunDeng]

@yjgaoustc Congratulations, you are very well deserved!