Shivangi Patel

[honey @Honey710108210]

今天带爸去医院检查，我说你在柱子等我，我去拿检查结果、我回来。猛然看到那个曾经我心中的依靠，心中无所不能的爸爸像个小孩子一样一动不动的站在那等着我、心里瞬间无比难受，发现自己俨然成为了父母心中的大人，而爸爸却在自己眼中变成了小孩，当角色互换的时候，突然间有种说不出的心酸…

[Insider Paper @TheInsiderPaper]

BREAKING: New footage shows absolutely horrifying scenes along the China-Nepal border amid devastating flash floods, hundreds missing, many feared dead

[Matthew Cappucci @MatthewCappucci]

Among the most terrifying videos I've ever seen. Hundreds missing.

This was along the Bhotekoshi River along the Nepal/Tibet border around 9 a.m. local time. Hundreds missing.

A 4.4 magnitude quake induced a mudslide/landslide that must have un-dammed a body of water. (That can include even a natural dam that was preventing a large volume of water from rushing downhill.)

[゙゙ @reallutherr]

btw, falling in love with you has been one of the most beautiful and healing experiences i've ever had

[Back On This App and It’s Still Hell @wickdchiq]

This is racism. Islamophobia, to be exact

[` @literaturelisa]

“Asking is a moment’s shame; not asking is a lifetime’s shame”

— Japanese Proverb

[Ramshahahaider🌻 @noturdrwatson]

until you realize, the noise of the family is the calmness of the heart ♥️

[🍂 @Lovandfear]

“All houses are dark until the mother wakes up.”

-Khalil Gibran #WomensDay

[Turkic Archives @TurkishArc]

Protect all children. Even if they aren’t yours. No exceptions.

[‏ً @omgsidewalks]

"I did the best I could with the knowledge I had at that time."

Mistakes are part of being human. Growth comes from learning.

[madeleine✶ @pilatesgirly]

life changing stuff

[anothertara 🌙 @anotherrtara]

Mahmoud Darwish

“All roads lead to you,
even the ones I took to forget you”

[Nathan @OIuwatosin]

One thing I love about traveling, is that it breaks the illusion that your current life is the only possible one.

[mia @httpsosweet]

Everything is so fun when you do it with the person you love the most

[Shivangi Patel @Shivangiipatel]

@httpsosweet So true!! 💘💘 @hardhik_t

[Time Capsule Tales @timecaptales]

Nickelodeon's "Oswald" from the early 2000s is proof that the shows we watched as kids were lower stimulation

[Vala Afshar @ValaAfshar]

Dr. Mariano Barbacid and his team developed a cure for pancreatic cancer in mice without side effects.

Dr. Barbacid is now asking for financial support in order to continue his research for a cure suitable for humans.

[Karen Tumulty @ktumulty]

My late cousin, who I adored and miss every day, once said to me: Never make fun of someone for mispronouncing a word. It means they learned it by reading.

[Aakash Gupta @aakashgupta]

This isn’t a random scientist who got lucky.

Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.

KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.

The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.

Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.

The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.

Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.

[Mayor Zohran Kwame Mamdani @NYCMayor]

As tens of thousands across America protest the violence that ICE sows with impunity, federal agents shot and killed another person in Minneapolis today.

ICE terrorizes our cities. ICE puts us all in danger. Abolish ICE.