Nacho

[Massimo @Rainmaker1973]

A new shot literally regrows knee cartilage.

Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).

The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.

In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.

This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.

The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.

Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.

Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.

[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]

[Shels Bella @ShelsBellaen]

wisdom teeth are weird

[The Best @TheBestqueenx]

A man photographed the Sun every day for three years from the same spot and at the same time.
He then combined all the images to reveal the Sun’s movement across the sky throughout the year.

[Massimo @Rainmaker1973]

How a simple paper glider stays aloft using steady airflow and basic aerodynamics

[Aurora Aveneu @aveneu_]

Is self-defense just about cunning? The tactics are too elaborate…

[That's Freaking Amazing @DesireToSee]

Horses don't just feel your touch - they sense your soul

[Massimo @Rainmaker1973]

No other species on Earth has a teamwork system quite like ants.

[Wonder of Science @wonderofscience]

Visualizing magnetic field lines with a cylindrical bar magnet and iron powder suspended in oil.

[Massimo @Rainmaker1973]

China just unveiled the world’s first medical ‘bone glue’ that heals fractures in minutes, with no metal implants, no follow-up surgery.

Inspired by oysters, this breakthrough could transform fracture treatment worldwide.

[Betsy Gain @BetsyGain]

the most ingenious invention in drilling

[Massimo @Rainmaker1973]

Ocean

[The Husky @Mr_Husky1]

24-year-old Gregory McCalium forced his way into the home of 73-year old pensioner Frank Corti and his wife.

Waving his kn*fe around, he believed he had found an easy target for the night.

He couldn't have been more wrong/

What he did not know was that Corti had spent his early years boxing during his service with the Royal Engineers in the British Army, and was a former champion.

When McCalium ran at him with a six inch kn*fe, Corti dodged multiple attempts to st*b him, then responded with a powerful right hook and a quick jab that knocked the younger man to the floor.

The retired boxer then easily restrained the intruder and held him there until police arrived to finish the job.

Prosecutors later said the burglar's injuries were so severe that he looked like he had been in a car accident.

A judge told the intruder he had “got what he deserved” before sentencing him to four and a half years in prison.

[How Things Are Manufactured @HTM_Official_]

When the pressure outside is stronger than the pressure inside

[Daily Life Hacks @ThePinchh]

Simple outdoor tips everyone should know

[Interesting things @awkwardgoogle]

This is the process of how traditional olive oil is pressed without heat

[Massimo @Rainmaker1973]

Tortoises sometimes exhibit aggression towards dark-colored objects, particularly black items.

[Massimo @Rainmaker1973]

How rotational atherectomy removes hardened plaque from arteries

[Massimo @Rainmaker1973]

The geomorphology of a river

[🎞️ MinuteEarth]

[Massimo @Rainmaker1973]

Unlock neck tension starting from your thumb.

This simple stretch glides the nerves, relaxes the forearm, and helps release tight neck muscles.

[Craft Gallery @5min__crafts]

Simple backyard project