Shmuel Shoham

Working on therapies for prevention and treatment of coronavirus. Transplant Infectious Diseases physician at Johns Hopkins. @[email protected]

[Shmuel Shoham @ShohamTxID]

At our best infectious diseases experts can act as the synapses that connect surgeons, internists, pharmacists, microbiologists, epidemiologists and the patients to make good decisions.

[Shmuel Shoham @ShohamTxID]

@ShipraGoelMD @JHMed_ID @VeroDioverti we were just being playful with each other. Of course, we will see everyone as soon as possible and are very happy to help our colleagues and patients.

[Shmuel Shoham @ShohamTxID]

"Crude 30-day mortality following a positive COVID-19 test was 2.2% in 2020, then decreased before stabilizing to 0.8%–1.0% from 2023 onward." Some people forget just how bad COVID was back then. https://t.co/Lqf8aJfHek~

[Shmuel Shoham @ShohamTxID]

Triazole-resistant Aspergillus fumigatus in the Netherlands between 1994 and 2022: a genomic and phenotypic study - The Lancet Microbe https://t.co/gDpqVmfLDu

[Shmuel Shoham @ShohamTxID]

Two Pandemics, Compared: Reflections on HIV and COVID-19 https://t.co/CbNhyx2QN5

[Shmuel Shoham @ShohamTxID]

@AndrewMCameron wow!

[Shmuel Shoham @ShohamTxID]

@Bastards_Boston This team is starting to develop an identity and Duran is part of that. Players who can hit, run, play solid, defense (or are working on improving it), don't give up, and have an aggressive streak.

[Fahad Buskandar @f_buskandar]

A great opportunity for those wanting to learn and update themselves about infections in transplant and oncology patients.

[Shmuel Shoham @ShohamTxID]

https://t.co/fU185EbXpB
We are excited about this course. We are sure @Contagion_Live readers will find this course worthwhile

[Shmuel Shoham @ShohamTxID]

Aspergillus tanneri fast facts: Tends to be resistant to multiple antifungal agents, described in people with chronic granulomatous disease (CGD) Western parts of US, living in Western parts of the US. Disseminated and contiguous disease patterns

[Shmuel Shoham @ShohamTxID]

Clinical situation: should you use vancomycin as part of empiric therapy in patient with AML and pneumonia.
Answer from clinical trial: Not typically, if MRSA screen is negative - Talagtag - 2021 - Transplant Infectious Disease - Wiley Online Library https://t.co/N8HihhP6oA

[Shmuel Shoham @ShohamTxID]

@ross_prager Yes, but... medica school and residency and some fellowships, can be unforgivingly hard. So, it is ok to give yourself a break if you can't be happy during stretches of this time

[Shmuel Shoham @ShohamTxID]

Candida auris: a) adheres to skin and inanimate objects, b) colonization often clinically significant (compared to C. albicans), c) associated with outbreaks, d) often resistant to fluconazole, and sometimes echinocandins too. A good review article by Lionakis in NEJM in 2024

[Shmuel Shoham @ShohamTxID]

Teaching case: middle aged man with ulcerative colitis. Disease has been stable, but now seemingly flares. CMV viral load ~100K. Endoscopy: CMV colitis. CMV IgG had been negative previously. Now CMV IgM+. This is probably primary CMV infection with tissue invasive disease

[Shmuel Shoham @ShohamTxID]

For a patient in whom there is a high pre-test probability for Clostridium difficile infection: a positive C difficile PCR with a negative EIA for toxin, does not rule out C difficile. False negative tests for the EIA toxin do occur.

[Shmuel Shoham @ShohamTxID]

most people voted for AmB, which would be my choice too

[Shmuel Shoham @ShohamTxID]

ID quiz: pt with neutropenia and blood culture with Rhodotorula. What is your fist line antifungal therapy

[Shmuel Shoham @ShohamTxID]

more about this organism and the skin
Seroy J, Antiporta P, Grim SA, Proia LA, Singh K, Clark NM. Aspergillus calidoustus case series and review of the literature. Transpl Infect Dis. 2017 Oct;19(5). doi: 10.1111/tid.12755. Epub 2017 Sep 19. PMID: 28741738.

[Shmuel Shoham @ShohamTxID]

Aspergillus calidoustus. I have seen it have a tendency for cutaneous involvement. Tends to be resistant to azoles. Here is another one from the literature. https://t.co/CFaGe9mrQY.

[Shmuel Shoham @ShohamTxID]

@JessicaLittleMD terrific review.

[Molecular Microbiology and Immunology @JohnsHopkinsMMI]

Thank you to today’s panel of MMI Thursday Seminar presenters — David Sullivan, MD, & our guests from @HopkinsMedicine moderator Dan Hanley, MD, @ShohamTxID, Nicole McBee & Karen Lane! Great interactive discussion about their multi-center #COVID-19 clinical trial