ShorterLab

Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpenn

[ShorterLab @ShorterLab]

UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins: Cell https://t.co/LBbmPZeqOI

[ShorterLab @ShorterLab]

SFPQ dysregulation promotes TDP-43 pathology through a pathogenic feedback loop https://t.co/Uh0k7vS0eT

[ShorterLab @ShorterLab]

An activity-modulated transport route across myelin (TRAM) for motor-driven organelle transfer in oligodendrocytes: https://t.co/hrfSsta1PM

[ShorterLab @ShorterLab]

The shape of fitness functions and the distribution of mutational effect sizes jointly limit adaptation by regulatory mutations: https://t.co/mWdRliJo9n

[ShorterLab @ShorterLab]

BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin: https://t.co/5SJoWC3kad

[ShorterLab @ShorterLab]

Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells: https://t.co/StcSWMcOod

[ShorterLab @ShorterLab]

XunZi, an AI biologist, reveals disease-modifying targets: https://t.co/IvC9tfCuja

[ShorterLab @ShorterLab]

A molecular switch for coordinating kinesin and dynein transport of mitochondrial cargo | Science https://t.co/lxVXNsJrEG

[Alzforum @alzforum]

No longer just for Aβ antibodies, brain shuttles are being customized to usher other antibodies, enzymes, and oligonucleotides into the brain.https://t.co/msq1A3wsOI https://t.co/1yrMBU9Ilp

[ShorterLab @ShorterLab]

Distinct amyloid-β filament fold in individuals with APP Flemish mutation: https://t.co/5DyZmQQ3cM

[ShorterLab @ShorterLab]

Systematic and proactive evaluation of AIRE missense variant effects: The American Journal of Human Genetics https://t.co/cEVGezWUDr

[ShorterLab @ShorterLab]

An ER stress-responsive RNA rheostat for programmable gene and mRNA therapies: Cell Chemical Biology https://t.co/mgmML4gxkP

[ShorterLab @ShorterLab]

Aggregation and propagation of TAF15 trigger neurodegeneration: Neuron https://t.co/0RaeJOk9yc

[ShorterLab @ShorterLab]

Tau-induced mitochondrial reverse electron transport drives neurodegeneration: Neuron https://t.co/QJDkNh4Yz5

[ShorterLab @ShorterLab]

Loss of Tubulin Tyrosination in Purkinje Neurons Does Not Cause Their Degeneration https://t.co/3hfeRdVr46

[ShorterLab @ShorterLab]

Reduced tubulin polyglutamylation perturbs neuronal function and causes late-onset neurodegeneration https://t.co/aKo4HmBV6R

[ShorterLab @ShorterLab]

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease: https://t.co/pIRywpvTdW

[John Clark @JClarkNBCS]

And tonight Luis Arraez has his first HR with the Phillies.

He is bringing the vibes

He has the most hits in baseball since 2022

[ShorterLab @ShorterLab]

DDX3X syndrome mutations lock DDX3X-RNA conformational states to drive persistent pathological condensation and neuronal death: https://t.co/EB8gJuCH1B

[ShorterLab @ShorterLab]

Human spinal interneurons repair the injured rat spinal cord through synaptic integration | Science Translational Medicine https://t.co/HW1KQRZyxc

[ShorterLab @ShorterLab]

An ancient mitochondrial program tunes translation to haem availability: https://t.co/lkljHLExD2