SimulaBetaTeam

Current news on #insulin-#glucose #homeostasis and the physiological simulation software #SimulaBeta

[International Pascal Congress @Pascal_Congress]

Dr. @drjwdietrich, a renowned researcher, gave a plenary talk in the IPC, explaining how he and his collaborators use Object Pascal in his labs. Enjoy the talk ! #Pascal #Programming #research #IPC #InternationalPascalCongress #ObjectPascal https://t.co/TxZXAUimLB

[Scientific Pascal @SciPasTips]

When it comes to performance, #Object_Pascal is a preferable programming language for computer #simulations in life sciences.

@SERGIO_M_T @freepascaldev @LazarusDev @lazarusforum

[Johannes W. Dietrich @drjwdietrich]

@UriAlonWeizmann @omer_karin Therefore, the non-increased and, in many cases, even reduced beta cell function in metabolic syndrome may not mirror an "either-or" question but be part of continuous evolution. It may be a source of prediabetes and diabetes but also prevent insulinoma.

https://t.co/bk5kdmNdOg

[Johannes W. Dietrich @drjwdietrich]

The answer to this important and open question may be in glucose toxicity leading to a biphasic response, thereby preventing neoplastic effects of dynamical compensation by mutant takeover.

@UriAlonWeizmann @omer_karin

https://t.co/sVO7YEZUEB

[Johannes W. Dietrich @drjwdietrich]

What is the primary event in the pathogenesis of type 2
#diabetes – dysfunction of pancreatic beta cells or hypersecretion of #insulin? This question is still unsolved and may represent a chicken-and-egg problem.

https://t.co/lSRrf1kCkh

[Ruhr-Universität Bochum @ruhrunibochum]

#Diabetes wird oft zu spät erkannt. Mathematische Modellierung könnte helfen. Eine einfache Blutprobe ist damit aussagekräftiger als ein komplexer Test. ^md https://t.co/ubIot7Z9ye

[SimulaBetaTeam @SimulaBetaTeam]

@DDG_Tweets @DG_Endo SPINA Carb may detect prediabetes even earlier, and with lower cost and higher precision.

[Wiley in research @wileyinresearch]

Can a basic blood test using two values detect diabetes early? 🩸

A study published in @DiabetesJdb introduces "SPINA Carb," an affordable method using insulin and glucose for precise evaluation.

Click below to learn more in @medical_xpress. 👇
https://t.co/eMn2cICYia

[Scientific Pascal @SciPasTips]

A novel method for early detection and #endotyping of #Diabetes mellitus relies on software written in #ObjectPascal.

Today, this innovative approach is covered by all major press agencies and news channels all over the globe.

https://t.co/PQnfqurvt4

[Scientific Pascal @SciPasTips]

@SimulaBetaTeam This #Pascal-based software helped to develop a potentially revolutionary new method for early diagnosis of diabetes. And the paper comes with source code in #ObjectPascal.

https://t.co/MBN27NM5IV

[Jessie Inchauspe @glucosegoddesss]

PSA on Red Lentil Pasta

The pasta and the lentils are composed of the same thing: red lentils. But the pasta leads to a much bigger spike. Why? Probably because in the refining process in which the lentils are turned into lentil *flour* to make the pasta, their structure is changed. The “matrix” or the food is changed. Fiber particules are pulverised.

Now there are no proper studies looking at this (if you know one, let me know), but this was an interesting n=1 experiment. Thoughts? What do you think?

PS it’s fine to have lentil pasta of course. But it’s probably always best to have the original, unprocessed whole food.

[SimulaBetaTeam @SimulaBetaTeam]

Computer simulations with #SimulaBeta had a key role in the development of the fasting-based disposition index SPINA-DI, a substantially improved method to assess the function of #insulin-#glucose homeostasis and for early diagnosis of #diabetes mellitus. https://t.co/EJrQbJbkEn

[Johannes W. Dietrich @drjwdietrich]

Einladung: Zweiter Tag der #Diabetestechnologie.
20. und 21.10.2023, Universitätsklinik St. Josef Hospital

Informationsveranstaltung für Betroffene und Interessierte
Medizinisch-wissenschaftliches Programm
Industrieausstellung

@RUBMedizin @DDG_Tweets

https://t.co/wpqewEqnln

[Johannes W. Dietrich @drjwdietrich]

@tednaiman @DietDoctor @drcateshanahan @docsopinion @JeffStanleyMD @drrcpatel @drjasonfung @FatEmperor @davidludwigmd @Gearoidmuar This is interesting and important. SPINA Carb, a recently published method for assessing beta cell function and insulin sensitivity, may, however, deliver more accurate results by factoring in the nonlinear nature of the feedback loop. https://t.co/YMdgfmzWYT

[SimulaBetaTeam @SimulaBetaTeam]

#SimulaBeta 3.1.2 is available. This service release fixes several bugs and is the first version to be based on #CyberUnits Bricks 2.0. @CyberUnitsTeam

https://t.co/4G2BKksRH4
https://t.co/G586O9wWwW
https://t.co/AHVy1Mr90K

[SimulaBetaTeam @SimulaBetaTeam]

@CyberUnitsTeam Despite significant new functions (justifying the version jump from 1.1.1 to 2.0.0) the CyberUnits Bricks library retains sufficient compatibility, so that SimulaBeta can be readily compiled with the new version. It will be the basis for our next release.

[Endocrine Today @EndocrineToday]

ICYMI: “Age, hypertension, free triiodothyronine, LDL and HDL were significant predictors for #diabetes among patients with #thyroid nodules.” @JOCMR_journal @ElmerPress https://t.co/YHC24sUvV0

[International Pascal Congress @Pascal_Congress]

Dear colleagues, if any of you is a researcher or PhD student, you can present your research in using any language of the Pascal family in the IPC 2023. Research projects submitted will be eligible for publication in a special issue of the Advances in Distributed Computing and Artificial Intelligence Journal. https://t.co/huCEVmHLm3

[SimulaBetaTeam @SimulaBetaTeam]

#SimulaBeta 3.1.1 is available. This bug fix release addresses a memory leak and an issue with the GUI of #LOREMOS.

https://t.co/4G2BKksRH4
https://t.co/CzmERMHEvp
https://t.co/SVtKzERhW9
https://t.co/G586O9wWwW
https://t.co/xiFATGPS2Q

[Fascinating @fasc1nate]

In 1922, a team of scientists went to the Toronto General Hospital, where numerous children with diabetes - often upwards of 50 - were housed in wards. Most of these children were in diabetic comas.

In what can only be described as their deathbeds, these children were waiting for a fate that, at the time, was deemed certain.

However, these scientists, brimming with determination, promptly began administering a newly purified insulin.

As they injected the final comatose child, a miracle happened - the first child who had received the injection started to regain consciousness.

And, one after another, the rest of the children also began to wake up from their diabetic comas. What was once a room of despair and imminent death had become a beacon of hope and joy.

The discovery of insulin was made by Frederick Banting and Charles Best under the supervision of John Macleod at the University of Toronto during the early 1920s.

They were assisted by James Collip, who played a crucial role in purifying insulin, thus paving the way for successful diabetes treatment. Their ground-breaking work earned Banting and Macleod the prestigious Nobel Prize in 1923.