Verónica @Sinfoniia - Twitter Profile

26 days ago

🧬 #ScienceSaturday ❓ Why does immunotherapy work so well for some cancers, but often fail in #glioblastoma, one of the most aggressive brain cancers? ➡️ A new study in @NatureCancer suggests the answer may depend less on how many DNA mutations a tumor has, and more on the tumor’s “cell state,” or what the cancer cells are actively doing. ➡️ Researchers studied 181 glioblastoma samples from patients treated with immune checkpoint blockade, a type of immunotherapy designed to help T cells recognize and attack cancer. ➡️ They found that glioblastomas in a mesenchymal, or MES, state were linked to better survival after immunotherapy. These tumors appeared more “immune-visible,” with higher levels of HLA class I, a signal that helps T cells recognize abnormal cells, and more T cell infiltration. ➡️ Surprisingly, #tumor mutational burden, a marker often used to predict immunotherapy response in other cancers, did not predict better outcomes in this glioblastoma group. ➡️ The study also revealed a possible escape route: after #immunotherapy, some tumors shifted away from the MES state toward non-MES states, which may make them less recognizable to the immune system and more resistant to treatment. 🧠 Why this matters: Glioblastoma has been extremely difficult to treat, and checkpoint immunotherapy has mostly been disappointing in this disease. This study suggests that future trials may need to look at a tumor’s RNA “activity pattern,” not just its #DNA mutations, to identify patients who may be more likely to benefit. ✨ Big takeaway: In glioblastoma, the tumor’s current “state of mind” may help predict whether immunotherapy can see it, attack it, and make a difference. Read more here: https://t.co/o2Y1JVSdGy @Nature @DanaFarber @Harvard @harvardmed @MassGenBrigham @broadinstitute @IBMResearch @DanaFarberNews @EAChiocca @JackYGhannam

PatrickHwuMD's tweet photo. 🧬 #ScienceSaturday

❓ Why does immunotherapy work so well for some cancers, but often fail in #glioblastoma, one of the most aggressive brain cancers?

➡️ A new study in @NatureCancer suggests the answer may depend less on how many DNA mutations a tumor has, and more on the tumor’s “cell state,” or what the cancer cells are actively doing.

➡️ Researchers studied 181 glioblastoma samples from patients treated with immune checkpoint blockade, a type of immunotherapy designed to help T cells recognize and attack cancer.

➡️ They found that glioblastomas in a mesenchymal, or MES, state were linked to better survival after immunotherapy. These tumors appeared more “immune-visible,” with higher levels of HLA class I, a signal that helps T cells recognize abnormal cells, and more T cell infiltration.

➡️ Surprisingly, #tumor mutational burden, a marker often used to predict immunotherapy response in other cancers, did not predict better outcomes in this glioblastoma group.

➡️ The study also revealed a possible escape route: after #immunotherapy, some tumors shifted away from the MES state toward non-MES states, which may make them less recognizable to the immune system and more resistant to treatment.

🧠 Why this matters: Glioblastoma has been extremely difficult to treat, and checkpoint immunotherapy has mostly been disappointing in this disease. This study suggests that future trials may need to look at a tumor’s RNA “activity pattern,” not just its #DNA mutations, to identify patients who may be more likely to benefit.

✨ Big takeaway: In glioblastoma, the tumor’s current “state of mind” may help predict whether immunotherapy can see it, attack it, and make a difference.

Read more here: https://t.co/o2Y1JVSdGy

@Nature @DanaFarber @Harvard @harvardmed @MassGenBrigham @broadinstitute @IBMResearch @DanaFarberNews @EAChiocca @JackYGhannam

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Dr. Rodrigo Arteaga

@DocArteaga

4 months ago

Entrena piernas. Fortalece glúteos. Haz sentadillas. No para verte bien. Para levantarte del suelo a los 75. Para cargar tu maleta a los 70. Para vivir sin dolor a los 65. Tu cuerpo de hoy construye tu independencia de mañana.

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