Wiep Klaas Smits

Assoc. prof. @LUMC_Leiden/CMAT. Cdiff, DNA replication, AMR, microbiome, anaerobes. Clostpath SC. Education officer ESGCD. Also: @smitslab.bsky.social

[Wiep Klaas Smits @SmitsLab]

[🔔] Publication alert! The CloDiCo trial is now published in @NatureComms @NaturePortfolio (Editor's choice!). This is the work of an amazing team, and led by PhD student Annefleur Hensen. Check out this thread [👇] for a summary of the study.
https://t.co/s50Emfm4gv
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[Jan-Willem Veening @JWVeening]

New preprint! Led by @aya_iizuka & @MVMazzuoli we ask what helps Staphylococcus aureus enter, survive inside and evade treatment in human monocytes.
https://t.co/o1nlWIgToJ

[Wiep Klaas Smits @SmitsLab]

🚨publication alert: Collateral effects of antibiotic resistance in Campylobacter jejuni - https://t.co/4qKNrH2vKU

[Christian Speck @Speck_Lab]

🧬 Delighted to share our new Nature Communications paper! We show how MCM2-7 double hexamers become active helicases and trigger DNA melting in vivo. Led by Chris Weekes & L. Maximilian Reuter. Congratulations to the whole team!

https://t.co/8TUeKvjjn0
#DNAReplication

[Wiep Klaas Smits @SmitsLab]

Look what arrived in the mail! @SpringerNature @AuchtungJ

[Wiep Klaas Smits @SmitsLab]

Thanks to @BrittonTML for including us on this work!
Acquisition of a gene cluster in Clostridioides difficile PCR ribotype 023 strains enables xylitol utilization | mSphere https://t.co/OKAcPUVz7i

[Ed Kuijper @EdKuijper2]

ICDS 2026: see https://t.co/vBP6K2UGzw

[Wiep Klaas Smits @SmitsLab]

Full article: Genomic evolution and re-emergence of a multidrug-resistant Clostridioides difficile RT027 clone with reduced vancomycin susceptibility driving a prolonged hospital outbreak https://t.co/cp1mofdWfI

[Wiep Klaas Smits @SmitsLab]

Full article: The emergence and biological characteristics of linezolid-resistant Clostridioides difficile isolates in the Asia-Pacific region https://t.co/q5FDjfke0i

[Wiep Klaas Smits @SmitsLab]

Extended-pulsed fidaxomicin versus conventional dosing in patients at high risk of recurrence of Clostridioides difficile infection: a multicentre cohort study. https://t.co/Iz5QhCuod2

[Wiep Klaas Smits @SmitsLab]

Intestinal muscularis in health and disease https://t.co/ubUpJckh9Q

[Wiep Klaas Smits @SmitsLab]

More in a thread on Bluesky: https://t.co/kZhiTnG3jk

[Wiep Klaas Smits @SmitsLab]

[🚨] Publication alert! Years of hard work is now published in @PNASNews - It's not everyday that a novel biosynthetic intermediate is identified in bacteria, so check this out! https://t.co/k2us2Pw5VS

[Wiep Klaas Smits @SmitsLab]

Widespread immune systems protect bacteria against conjugative plasmids https://t.co/4VbOlJcFYL

[Wiep Klaas Smits @SmitsLab]

A plasmid-encoded H-NS protein selectively binds its own plasmid https://t.co/FmYyoz2aeh CC @DameLab

[Wiep Klaas Smits @SmitsLab]

Direct visualisation of post-replication gap formation at the bacterial RRS https://t.co/0JMKl6YSp3

[Wiep Klaas Smits @SmitsLab]

3′ Exonuclease-mediated DNA assembly at room temperature and below https://t.co/SEGNHREYlh

[Wiep Klaas Smits @SmitsLab]

Thanks to our Department for highlighting our recent publication on their LinkedIn profile: https://t.co/Jl690oSl10

[Prof. Nikolai Slavov @slavov_n]

A deeper dive into the article we published last week in @Nature.

I will start with the framing and methodology as they are key to understanding the surprising results:

Proteomics experiments usually begin with an assumption.

https://t.co/XhD0ROD4jR

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[Huiluo Cao 曹慧荦 @hlcao]

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium | Nature Communications https://t.co/3tgm6dbCcS